Featured Publications
The impact of novel coronavirus COVID‐19 on noncommunicable disease patients and health systems: a review
Chang A, Cullen M, Harrington R, Barry M. The impact of novel coronavirus COVID‐19 on noncommunicable disease patients and health systems: a review. Journal Of Internal Medicine 2020, 289: 450-462. PMID: 33020988, PMCID: PMC7675448, DOI: 10.1111/joim.13184.Peer-Reviewed Original ResearchConceptsHealth system factorsNoncommunicable disease patientsNoncommunicable diseasesHealth systemLevels of health systemsSystemic factorsCare of patientsDisease-specific factorsPublic health measuresCare providersNCD patientsDisproportionate burdenHealth measuresCOVID-19Society statementEndocrine disordersPatientsCareLong-term effectsDisease patientsHealthDiseasePandemic disruptionCoronavirus diseaseProviders
2021
Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis
Chen I, Vedula V, Malik S, Liang T, Chang A, Chung K, Sayed N, Tsao P, Giacomini J, Marsden A, Wu J. Preoperative Computed Tomography Angiography Reveals Leaflet-Specific Calcification and Excursion Patterns in Aortic Stenosis. Circulation Cardiovascular Imaging 2021, 14: 1122-1132. PMID: 34915729, PMCID: PMC9206593, DOI: 10.1161/circimaging.121.012884.Peer-Reviewed Original ResearchConceptsAortic valve areaAortic stenosisNoncoronary cuspMale patientsCalcium scoreCoronary cuspValve areaNormal valvesEvaluation of aortic stenosisTranscatheter aortic valve replacementAortic valve replacementComputed tomography angiogramRight coronary cuspLeft coronary cuspNormal aortic valveRight coronary arteryAS severityValve replacementLeaflet thickeningOstial occlusionCalcification loadAortic valveLeaflet excursionCoronary arteryPatients
2017
IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer
Wang L, Miyahira A, Simons D, Lu X, Chang A, Wang C, Suni M, Maino V, Dirbas F, Yim J, Waisman J, Lee P. IL6 Signaling in Peripheral Blood T Cells Predicts Clinical Outcome in Breast Cancer. Cancer Research 2017, 77: 1119-1126. PMID: 27879265, PMCID: PMC5334262, DOI: 10.1158/0008-5472.can-16-1373.Peer-Reviewed Original ResearchConceptsPeripheral blood T cellsBreast cancer patientsBlood T cellsCancer patientsT cellsIL6 levelsWorse relapse-free survivalPlasma IL6 levelsCancer cellsRelapse-free survivalSerum IL6 levelsAnti-inflammatory propertiesHost immune responseInvolved downregulationClinical outcomesPredictive biomarkersImmune responsePleiotropic cytokinePatientsIL6Cancer ResCancer progressionSurvivalDiagnosisCells
2014
Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy
Chang A, Weirich E. Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy. Case Reports In Medicine 2014, 2014: 107064. PMID: 25371679, PMCID: PMC4209775, DOI: 10.1155/2014/107064.Peer-Reviewed Original ResearchGamma-aminobutyric acidGamma-aminobutyric acid receptor agonistGamma-aminobutyric acid agonistSix-year historyOcular disturbancesReceptor agonistsFamily of syndromesParkinson's medicationsReceptor subtypesClinic visitsPharmacological treatmentMotor skillsSide effectsClassic variantAgonistsZolpidemMotor dysfunctionPatientsPSP patientsAminobutyric acidProgressive supranuclear palsyPatient consentMedicationEszopicloneNeuropsychological conditions