2024
KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes
Wang A, Fairhurst A, Liu K, Wakeland B, Barnes S, Malladi V, Viswanathan K, Arana C, Dozmorov I, Singhar A, Du Y, Imam M, Moses A, Chen C, Sunkavalli A, Casco J, Rakheja D, Li Q, Mohan C, Clayberger C, Wakeland E, Khan S. KLF13 promotes SLE pathogenesis by modifying chromatin accessibility of key proinflammatory cytokine genes. Communications Biology 2024, 7: 1446. PMID: 39506084, PMCID: PMC11541912, DOI: 10.1038/s42003-024-07099-0.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusMyeloid cellsLupus nephritisT cellsKidneys of lupus-prone miceSystemic lupus erythematosus pathogenesisLevels of proinflammatory cytokinesLupus-prone miceActivated myeloid cellsActivated T cellsT cell activationProduction of RANTEST cell hyperactivityProinflammatory cytokine genesAssociated with increased productionLupus pathogenesisProinflammatory cytokines/chemokinesSle1 locusLupus erythematosusImmune activationProinflammatory cytokinesCytokine signaling pathwaysCytokine genesGenome-wide transcriptional changesReceptor ligands
2010
Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
Wang A, Guilpain P, Chong BF, Chouzenoux S, Guillevin L, Du Y, Zhou XJ, Lin F, Fairhurst A, Boudreaux C, Roux C, Wakeland EK, Davis LS, Batteux F, Mohan C. Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus. Arthritis & Rheumatism 2010, 62: 3436-3446. PMID: 20722038, PMCID: PMC8972909, DOI: 10.1002/art.27685.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus nephritisSLE patientsCXCR4 expressionPeripheral blood leukocytesNeuropsychiatric SLEB cellsLupus erythematosusBlood leukocytesSLE Disease Activity Index (SLEDAI) scoreClasses of LNDisease activity index scoreSeverity of LNNeuropsychiatric systemic lupus erythematosusCentral nervous system involvementClass IV lupus nephritisActive neuropsychiatric systemic lupus erythematosusCXCR4/CXCL12 axisAnti-CXCL12 antibodyActivity index scoreNervous system involvementSubset of patientsMurine lupus modelsGlomeruli of kidneysPotential therapeutic target
2009
CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus
Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. CXCR4/CXCL12 Hyperexpression Plays a Pivotal Role in the Pathogenesis of Lupus. The Journal Of Immunology 2009, 182: 4448-4458. PMID: 19299746, PMCID: PMC2946082, DOI: 10.4049/jimmunol.0801920.Peer-Reviewed Original ResearchConceptsMurine modelIncreased CXCR4 expressionPathogenesis of lupusB cell subsetsPromising therapeutic targetCXCR4/CXCL12Multiple murine modelsB cell survivalLupus nephritisActive nephritisSerum autoantibodiesCell subsetsCXCR4 expressionInflammatory cytokinesNephritic kidneysOrgan diseasePathogenic rolePlasma cellsLeukocyte traffickingTherapeutic targetLupusPeptide antagonistCXCR4Surface moleculesNephritis