A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis
Daboul L, O’Donnell C, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree B, Freeman L, Henry R, Longbrake E, Oh J, Papinutto N, Pelletier D, Prchkovska V, Raza P, Ramos M, Samudralwar R, Schindler M, Sotirchos E, Sicotte N, Solomon A, Shinohara R, Reich D, Sati P, Ontaneda D. A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis. Multiple Sclerosis Journal 2023, 30: 25-34. PMID: 38088067, PMCID: PMC11037932, DOI: 10.1177/13524585231214360.Peer-Reviewed Original ResearchConceptsCentral vein signMultiple sclerosisPositive lesionsInter-rater agreementDiagnosis of MSMagnetic resonance imaging (MRI) biomarkersDiagnostic performancePossible multiple sclerosisInter-rater reliability assessmentGood diagnostic performanceMcDonald criteriaMulticenter studyVein assessmentMean ageVein signImaging biomarkersLesionsMRI sequencesCharacteristic curveSclerosisPatientsDiagnosisAssessmentParticipantsOptimal methodDigital Phenotypes of Instability and Fatigue Derived From Daily Standing Transitions in Persons With Multiple Sclerosis
VanDyk T, Meyer B, DePetrillo P, Donahue N, O’Leary A, Fox S, Cheney N, Ceruolo M, Solomon A, McGinnis R. Digital Phenotypes of Instability and Fatigue Derived From Daily Standing Transitions in Persons With Multiple Sclerosis. IEEE Transactions On Neural Systems And Rehabilitation Engineering 2023, 31: 2279-2286. PMID: 37115839, PMCID: PMC10408384, DOI: 10.1109/tnsre.2023.3271601.Peer-Reviewed Original ResearchConceptsPrediction of fall riskStanding transitionsDigital phenotypingFall riskNon-fallersSymptom monitoringPhysician assessmentMultiple sclerosisBiweekly assessmentsClinical metricsCharacterize symptomsHome monitoringSymptomsFatigueMotor instabilityAccelerometryFallersAssessmentPwMSPersonsApplications of wearablePhysiciansIsolation periodActivity classifierIntervention