2024
Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin‐differences study
Stock S, Lacey R, Arseneault L, Caspi A, Crush E, Danese A, Latham R, Moffitt T, Newbury J, Schaefer J, Fisher H, Baldwin J. Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin‐differences study. Journal Of Child Psychology And Psychiatry 2024 PMID: 39532290, DOI: 10.1111/jcpp.14070.Peer-Reviewed Original ResearchMental health problemsAdverse childhood experiencesMaternal warmthMental healthHealth problemsAdult supportEnvironmental confoundersTwin-difference analysesChildren exposed to adversityAssociated with mental health problemsAdverse childhood experience exposureLevels of mental health problemsTwin differences designExposure to adverse childhood experiencesPopulation-representative birth cohortImprove mental healthSame-sex twinsAged 5Experiences of adversityApparent protective effectHeritable vulnerabilityChild reportsSpeech samplesChildhood experiencesCo-twin
2023
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Matthews T, Rasmussen L, Ambler A, Danese A, Eugen-Olsen J, Fancourt D, Fisher H, Iversen K, Schultz M, Sugden K, Williams B, Caspi A, Moffitt T. Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood. Brain Behavior And Immunity 2023, 115: 727-736. PMID: 37992788, PMCID: PMC11194667, DOI: 10.1016/j.bbi.2023.11.022.Peer-Reviewed Original ResearchConceptsSoluble urokinase plasminogen activator receptorC-reactive proteinSystemic chronic inflammationInterleukin-6Triage StudyMedical patientsChronic inflammationAge 45Social isolationStudy participantsHigher C-reactive proteinNew inflammation markerPopulation-representative birth cohortUrokinase plasminogen activator receptorEnvironmental Risk (E-Risk) Longitudinal Twin StudyHigher median levelsPlasminogen activator receptorDunedin Longitudinal StudyElevated markersSuPAR levelsSystemic inflammationInflammation markersInflammation biomarkersGeneral populationInflammation