Anasuya Dighe, PhD
Associate Research ScientistCards
About
Titles
Associate Research Scientist
Appointments
Medical Oncology and Hematology
Associate Research ScientistPrimary
Other Departments & Organizations
- Medical Oncology & Hematology
- Medical Oncology and Hematology
Education & Training
- PhD
- Indian Institute of Science, Computational Biology
- MSc
- University of Pune, Bioinformatics
- BSc
- University of Pune, Biotechnology
Research
Overview
Medical Research Interests
Biological Evolution; Computational Biology; Exome Sequencing
Publications
2025
Spatial Genomic Approaches to Investigate HOX Genes in Mouse Brain Tissues.
Shelar A, Dighe A. Spatial Genomic Approaches to Investigate HOX Genes in Mouse Brain Tissues. Methods Mol Biol 2025, 2889: 235-244. PMID: 39745616, DOI: 10.1007/978-1-0716-4322-8_16.Chapters
2023
Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts
Dighe A, Maziarz J, Ibrahim-Hashim A, Gatenby R, Kshitiz, Levchenko A, Wagner G. Experimental and phylogenetic evidence for correlated gene expression evolution in endometrial and skin fibroblasts. IScience 2023, 27: 108593. PMID: 38174318, PMCID: PMC10762354, DOI: 10.1016/j.isci.2023.108593.Peer-Reviewed Original ResearchGene expression changesGene expression evolutionEndometrial stromal fibroblastsExpression evolutionExpression changesCell typesGene expressionSimilar gene expression changesSubstantial gene expression changesGene expression profilesSkin fibroblastsMultiple cell typesEvolutionary correlationPhylogenetic evidenceEvolutionary changeDermal skin fibroblastsMammalian speciesExpression profilesPlacental invasivenessComparative datasetCancer growthCultured skin fibroblastsStromal fibroblastsFibroblastsMouse strains
2022
Proteotype coevolution and quantitative diversity across 11 mammalian species
Ba Q, Hei Y, Dighe A, Li W, Maziarz J, Pak I, Wang S, Wagner GP, Liu Y. Proteotype coevolution and quantitative diversity across 11 mammalian species. Science Advances 2022, 8: eabn0756. PMID: 36083897, PMCID: PMC9462687, DOI: 10.1126/sciadv.abn0756.Peer-Reviewed Original ResearchConceptsMammalian speciesRNA metabolic processesCommon mammalian speciesUbiquitin-proteasome systemEvolutionary profilingMammalian lineagesProteomic methodsProtein degradationProtein abundanceGene expressionProtein expression levelsHigh interspeciesMetabolic processesCovariation analysisFunctional roleNucleotide levelExpression levelsQuantitative diversityCoevolutionMammalsSpeciesRemarkable variationExpressionTranscriptomeBiological variabilityTracing the cis-regulatory changes underlying the endometrial control of placental invasion
Suhail Y, Maziarz JD, Novin A, Dighe A, Afzal J, Wagner G, Kshitiz. Tracing the cis-regulatory changes underlying the endometrial control of placental invasion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2111256119. PMID: 35110402, PMCID: PMC8832988, DOI: 10.1073/pnas.2111256119.Peer-Reviewed Original ResearchConceptsCis-regulatory changesComparative genomic investigationCis-regulatory elementsTranscription factor GATA2Placental invasionCancer cell invasionEutherian mammalsTranscription factorsGenomic investigationsInvasibilityGene knockoutGenomic mechanismsDifferent speciesCell invasionEndometrial controlCancer malignancyDegree of invasionSpecies differencesCancer disseminationMaternal endometriumInterspecies differencesPlacental trophoblastsStromal cellsStromal characteristicsInvasionEvolution of higher mesenchymal CD44 expression in the human lineage
Ma X, Dighe A, Maziarz J, Neumann E, Erkenbrack E, Hei YY, Liu Y, Suhail Y, Kshitiz, Pak I, Levchenko A, Wagner GP. Evolution of higher mesenchymal CD44 expression in the human lineage. Evolution Medicine And Public Health 2022, 10: 447-462. PMID: 36148042, PMCID: PMC9487634, DOI: 10.1093/emph/eoac036.Peer-Reviewed Original ResearchCell type-specific factorsType-specific factorsEndometrial stromal fibroblastsHuman lineageCell type-specific functionsCell typesExtracellular matrix receptorsExpression increasesGene expression increasesReporter gene experimentsEvolutionary changePositive selectionFunction of CD44Regulatory elementsMatrix receptorsRegulatory mechanismsGene experimentsCancer progressionInvasibilityCD44 expressionFetal-maternal interactionIsoform expressionLineagesExpressionStromal fibroblasts
2021
The Coevolution of Placentation and Cancer
Wagner GP, Kshitiz, Dighe A, Levchenko A. The Coevolution of Placentation and Cancer. Annual Review Of Animal Biosciences 2021, 10: 1-21. PMID: 34780249, DOI: 10.1146/annurev-animal-020420-031544.Peer-Reviewed Original ResearchNetwork Re-Wiring During Allostery and Protein-Protein Interactions: A Graph Spectral Approach.
Gadiyaram V, Dighe A, Ghosh S, Vishveshwara S. Network Re-Wiring During Allostery and Protein-Protein Interactions: A Graph Spectral Approach. Methods Mol Biol 2021, 2253: 89-112. PMID: 33315220, DOI: 10.1007/978-1-0716-1154-8_7.Chapters
Get In Touch
Contacts
Mailing Address
Medical Oncology & Hematology
Yale Center for Medical and Cellular Oncology, 300 George St
New Haven, Connecticut 06511
United States