2007
Crosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways
Tufro A, Teichman J, Banu N, Villegas G. Crosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways. Biochemical And Biophysical Research Communications 2007, 358: 410-416. PMID: 17490619, DOI: 10.1016/j.bbrc.2007.04.146.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorCell proliferationEndothelial growth factorNeurotrophic factorGDNF/RETEmbryonic kidney explantsUreteric bud branchingUreteric bud cellsC-RetGrowth factorRT-PCRVEGFNovel cooperative interactionVEGFR2Branching morphogenesisRETVEGFR2 autophosphorylationGDNFKidney developmentBud cellsUreteric budAdditive effectMajor regulatorKidney explantsPhosphorylation
2006
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP
Guan F, Villegas G, Teichman J, Mundel P, Tufro A. Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP. American Journal Of Physiology. Renal Physiology 2006, 291: f422-f428. PMID: 16597608, DOI: 10.1152/ajprenal.00448.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell DifferentiationCell LineCell SurvivalC-Reactive ProteinCytoskeletal ProteinsGene Expression RegulationIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceNerve Tissue ProteinsNeuropilin-2PodocytesProteinsProto-Oncogene Proteins c-aktReceptors, Vascular Endothelial Growth FactorRNA, MessengerSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2ConceptsWestern analysisAutocrine VEGFPodocyte VEGFGrowth factor signalingVEGFR2 mRNA levelsMRNA levelsEndothelial cell differentiationVascular endothelial growth factor signalingCompletion of developmentVascular patterningKidney morphogenesisFactor signalingPodocyte differentiationUndifferentiated podocytesLigand availabilityCell differentiationVEGFR2 phosphorylationDifferentiated conditionsImmortalized mouse podocytesProtein levelsProtein expressionMouse podocytesVEGFR2 mRNADifferentiated podocytesCD2AP