2022
Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype
Duvall J, Massaad E, Siraj L, Kiapour A, Connolly I, Hadzipasic M, Elsamadicy A, Williamson T, Shankar G, Schoenfeld A, Fourman M, Shin J. Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype. Neurosurgery 2022, 92: 83-91. PMID: 36305664, PMCID: PMC10158884, DOI: 10.1227/neu.0000000000002180.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerGrowth factor receptor 2Factor receptor 2Breast cancerHazard ratioSpine metastasesMolecular subtypesReceptor 2Retrospective multi-institutional studyHormone receptorsBreast cancer molecular subtypesPostoperative systemic therapySystemic treatment plansPoor physical activityRisk stratification toolSpinal metastasis surgeryCancer molecular subtypesMulti-institutional studyMassachusetts General HospitalMolecular featuresPostoperative chemotherapyBrain metastasesEndocrine therapy
2020
Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
Sujijantarat N, Hong CS, Owusu KA, Elsamadicy AA, Antonios JP, Koo AB, Baehring JM, Chiang VL. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. Journal Of Neuro-Oncology 2020, 148: 641-649. PMID: 32602021, DOI: 10.1007/s11060-020-03570-0.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyLonger overall survivalRadiation necrosisInterstitial thermal therapyBrain metastasesOverall survivalMedian volume decreaseMedian volume increaseBrain metastasis patientsPre-treatment patient characteristicsRetrospective chart reviewResultsTwenty-five patientsPre-treatment factorsBevacizumab patientsChart reviewMetastasis patientsLocal recurrencePatient characteristicsTreatment optionsTreatment responseBevacizumabPatientsLesional volumeThermal therapyStatistical significance
2017
Independent Association Between Preoperative Cognitive Status and Discharge Location After Surgery: A Strategy to Reduce Resource Use After Surgery for Deformity
Adogwa O, Elsamadicy AA, Sergesketter A, Vuong VD, Moreno J, Cheng J, Karikari IO, Bagley CA. Independent Association Between Preoperative Cognitive Status and Discharge Location After Surgery: A Strategy to Reduce Resource Use After Surgery for Deformity. World Neurosurgery 2017, 110: e67-e72. PMID: 29081391, DOI: 10.1016/j.wneu.2017.10.081.Peer-Reviewed Original ResearchConceptsNormal cognitive statusCognitive impairmentCognitive statusOlder patientsSLUMS scorePreoperative cognitive impairmentElective spinal surgeryPreoperative cognitive statusStandard deviation ageAdult degenerative scoliosisBaseline cognitive impairmentSevere cognitive impairmentMental status testsMild cognitive impairmentPostoperative lengthPreoperative scoresDeviation ageGeriatric patientsDegenerative scoliosisIndependent associationSpinal surgeryDeformity correctionPatientsSurgeryCognitive screeningDepression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery.
Elsamadicy AA, Adogwa O, Lydon E, Sergesketter A, Kaakati R, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Depression as an independent predictor of postoperative delirium in spine deformity patients undergoing elective spine surgery. Journal Of Neurosurgery Spine 2017, 27: 209-214. PMID: 28574333, DOI: 10.3171/2017.4.spine161012.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAge FactorsComorbidityDecompression, SurgicalDeliriumDepressionElective Surgical ProceduresFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOperative TimePostoperative ComplicationsPrognosisRetrospective StudiesRisk FactorsSpinal CurvaturesSpinal FusionSpineConceptsElective spine surgeryMultivariate logistic regression analysisPostoperative deliriumIndependent risk factorPostoperative complication rateSpine surgeryLogistic regression analysisPatient demographicsComplication rateIndependent predictorsDeformity patientsRisk factorsDepression groupAffective disordersSuperficial surgical site infectionSignificant between-group differencesInferior surgical outcomesPostoperative delirium rateResults Patient demographicsInitial hospital stayProportion of patientsRate of complicationsSurgical site infectionUrinary tract infectionDeep vein thrombosis
2016
Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes?
Adogwa O, Elsamadicy AA, Han JL, Cheng J, Karikari I, Bagley CA. Do measures of surgical effectiveness at 1 year after lumbar spine surgery accurately predict 2-year outcomes? Journal Of Neurosurgery Spine 2016, 25: 689-696. PMID: 26722957, DOI: 10.3171/2015.8.spine15476.Peer-Reviewed Original ResearchConceptsTransforaminal lumbar interbody fusionLumbar spine surgeryAnterior lumbar interbody fusionLong-term outcomesLateral interbody fusionLumbar interbody fusionSpine surgeryInterbody fusionSurgical effectivenessOutcome measuresSF-36 physical component summary scorePhysical component summary scoreLongitudinal assessmentPatient-reported outcome instrumentsAchievement of MCIDMultiinstitutional prospective studyVAS leg painComponent summary scoresClinical outcome dataPatient-centered measuresLogistic regression modelingIneffective patient careInstitutional registryOutcomes RegistrySF-36