2022
Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas
Hersh AM, Antar A, Pennington Z, Aygun N, Patel J, Goldsborough E, Porras JL, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas. Journal Of Neuro-Oncology 2022, 158: 117-127. PMID: 35538385, DOI: 10.1007/s11060-022-04017-4.Peer-Reviewed Original ResearchConceptsProgression-free survivalPredictors of survivalHigh tumor gradeResection extentTumor gradePoor survivalIntramedullary spinal cord astrocytomasPost-operative neurologic deficitsSingle comprehensive cancer centerTumor progression/recurrencePreoperative back painPre-operative presentationSpinal cord astrocytomasKaplan-Meier curvesProgression/recurrenceStandard of careComprehensive cancer centerLong-term survivalPurposeSurgical resectionBowel dysfunctionChemotherapy regimensNeurologic deficitsIntramedullary astrocytomasPatient demographicsComplete resection
2020
Comparison of epidemiology, treatments, and outcomes in pediatric versus adult ependymoma
Elsamadicy AA, Koo AB, David WB, Lee V, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeves BC, Kahle KT, DiLuna M. Comparison of epidemiology, treatments, and outcomes in pediatric versus adult ependymoma. Neuro-Oncology Advances 2020, 2: vdaa019. PMID: 32642681, PMCID: PMC7212900, DOI: 10.1093/noajnl/vdaa019.Peer-Reviewed Original ResearchDiagnosis of ependymomaCause mortalityOlder adultsYoung adultsCause mortality ratesTreatment risk factorsExtent of resectionComparison of EpidemiologyMultivariate logistic regressionSignificant differencesImpact of ageInfluence of ageAdult patientsSEER databaseSurgical treatmentSurvival outcomesEpendymoma patientsRisk factorsTumor gradeAdult ependymomasTreatment outcomesHistological classificationSupratentorial locationInternational ClassificationMortality rate