2024
The Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion
Mirpuri P, Khalid S, Colliander R, King P, Tao X, Elsamadicy A, Mehta A, Adogwa O. The Impact of Preoperative Spinal Injection Timing on the Postoperative Complications of Lumbar Fusion. World Neurosurgery 2024, 190: e121-e128. PMID: 39002778, DOI: 10.1016/j.wneu.2024.07.050.Peer-Reviewed Original ResearchTransforaminal lumbar interbody fusionCSF leakSurgical complicationsComplication rateIncidence of CSF leakRate of CSF leakSecondary outcomesRate of surgical complicationsSurgical complication ratePostoperative surgical complicationsSurgical site infectionDay of surgeryLumbar interbody fusionPostoperative complicationsSite infectionWound disruptionPostoperative rateAdult patientsLumbar fusionInterbody fusionIncreased riskPrimary outcomePatientsSurgeryPrimary analysis
2023
Outcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs
Khalid S, Mirpuri P, Thomson K, Elsamadicy A, Massaad E, Deysher D, Khilwani H, Adogwa O, Shin J, Mehta A. Outcomes Following 2-Level Cervical Interventions with Cage-and-Plate, Zero-Profile, or Arthroplasty Constructs. World Neurosurgery 2023, 180: e607-e617. PMID: 37797683, DOI: 10.1016/j.wneu.2023.09.117.Peer-Reviewed Original ResearchConceptsAdditional surgeryCervical interventionsPlate constructZero-profileMedical complicationsAnterior cervical proceduresDisc height restorationPostoperative medical complicationsOutcomes of patientsCervical disc diseaseLogistic regression modelsCervical proceduresSecondary outcomesSurgical complicationsIndex interventionPrimary outcomeIndex procedureHeight restorationDisc diseasePatientsSurgeryArthroplastyMotion limitationArtificial discComplicationsNovel Standalone Motion-Sparing Pelvic Fixation Prevents Short-Term Insufficiency Fractures After Midsacrectomies Without Sacrificing Normal, Mobile Lumbar Segments Traditionally Used for Stabilization
Lo S, Pieters T, Hersh A, Green R, Suk I, Pennington Z, Elsamadicy A, Sciubba D. Novel Standalone Motion-Sparing Pelvic Fixation Prevents Short-Term Insufficiency Fractures After Midsacrectomies Without Sacrificing Normal, Mobile Lumbar Segments Traditionally Used for Stabilization. Operative Neurosurgery 2023, 25: 278-284. PMID: 37278692, DOI: 10.1227/ons.0000000000000767.Peer-Reviewed Original ResearchConceptsSacral insufficiency fracturesMobile lumbar segmentsInsufficiency fracturesPelvic fixationPartial sacrectomyLumbar segmentsMedian age 59 yearsPrimary malignant bone tumorAge 59 yearsTreatment of choiceMalignant bone tumorsComprehensive cancer centerRetrospective data setConcomitant placementAdverse eventsOverall survivalPrimary outcomeSacral tumorsHistorical cohortMobile spineRetrospective studyCancer CenterLumbopelvic fixationOperative characteristicsBone tumorsEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2021
Impact of race on outcomes and healthcare utilization following spinal fusion for adolescent idiopathic scoliosis
Elsamadicy AA, Koo AB, David WB, Freedman IG, Kundishora AJ, Hong CS, Sarkozy M, Sciubba DM, Kahle KT, DiLuna M. Impact of race on outcomes and healthcare utilization following spinal fusion for adolescent idiopathic scoliosis. Clinical Neurology And Neurosurgery 2021, 206: 106634. PMID: 33979695, DOI: 10.1016/j.clineuro.2021.106634.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionPostoperative complicationsAdolescent idiopathic scoliosisPatient demographicsIdiopathic scoliosisAdolescent patientsSpine surgerySpinal fusionBlack cohortBaseline patient demographicsRate of complicationsMajority of patientsPosterior spine surgeryPosterior spinal surgeryMedian total costBaseline comorbiditiesHospital stayDischarge dispositionInpatient managementPostoperative outcomesBlood transfusionPrimary outcomeFemale patientsHealthcare utilizationHispanic patients
2020
Independent Association Between Type of Intraoperative Blood Transfusion and Postoperative Delirium After Complex Spinal Fusion for Adult Deformity Correction.
Elsamadicy AA, Adil SM, Charalambous L, Drysdale N, Koo AB, Lee M, Kundishora AJ, Camara-Quintana J, Kolb L, Laurans M, Abbed K, Karikari IO. Independent Association Between Type of Intraoperative Blood Transfusion and Postoperative Delirium After Complex Spinal Fusion for Adult Deformity Correction. Spine 2020, 45: 268-274. PMID: 31996654, DOI: 10.1097/brs.0000000000003260.Peer-Reviewed Original ResearchConceptsIntraoperative blood transfusionComplex spinal fusionAllogenic blood transfusionPostoperative deliriumBlood transfusionSpinal fusionIndependent associationDeformity correctionMultivariate nominal-logistic regression analysisPrimary complex spinal fusionAdult spine deformity patientsAdult deformity correctionBetter overall patient careGreater complication risksRetrospective cohort studySpine deformity patientsOverall patient careNominal logistic regression analysisMajor academic institutionHospital stayCohort studyBlood lossPrimary outcomeComplication riskDeformity patientsGeographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis
Koo AB, Elsamadicy AA, Kundishora AJ, David WB, Lee M, Hong CS, Lee V, Kahle KT, DiLuna M. Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis. World Neurosurgery 2020, 136: e347-e354. PMID: 31917315, DOI: 10.1016/j.wneu.2019.12.175.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisLength of surgeryAdolescent patientsSpinal fusionIdiopathic scoliosisMultilevel posterior spinal fusionHealth care resource utilizationGreater complication ratePosterior spinal fusionPosterior spinal surgeryPostoperative complicationsComplication ratePrimary outcomeAIS patientsSpinal surgeryPatientsSurgeryAdmissionRegional variationComplicationsFurther studiesOutcomesCohortScoliosisTotal cost
2019
Reduced Influence of Affective Disorders on 6-Week and 3-Month Narcotic Refills After Primary Complex Spinal Fusions for Adult Deformity Correction: A Single-Institutional Study
Elsamadicy AA, Charalambous L, Adil SM, Drysdale N, Lee M, Koo AB, Chouairi F, Kundishora AJ, Camara-Quintana J, Qureshi T, Kolb L, Laurans M, Abbed K, Karikari IO. Reduced Influence of Affective Disorders on 6-Week and 3-Month Narcotic Refills After Primary Complex Spinal Fusions for Adult Deformity Correction: A Single-Institutional Study. World Neurosurgery 2019, 129: e311-e316. PMID: 31132486, DOI: 10.1016/j.wneu.2019.05.135.Peer-Reviewed Original ResearchConceptsPrimary complex spinal fusionComplex spinal fusionNarcotic refillsPain scoresSpinal fusionAffective disordersDeformity correctionNarcotic useDeformity patientsAD cohortPatient-reported pain scoresAdult spine deformity patientsAdult deformity correctionPostoperative pain scoresPostoperative complication ratePreoperative narcotic useHigher pain scoresSpinal deformity patientsSpine deformity patientsMajor academic institutionAmbulatory statusComplication ratePatient demographicsPrimary outcomePostoperative perceptionCharacterization of Perinatal Risk Factors and Complications Associated With Nonsyndromic Craniosynostosis
Sergesketter AR, Elsamadicy AA, Lubkin DT, Krucoff KB, Krucoff MO, Muh CR. Characterization of Perinatal Risk Factors and Complications Associated With Nonsyndromic Craniosynostosis. Journal Of Craniofacial Surgery 2019, 30: 334-338. PMID: 30358747, DOI: 10.1097/scs.0000000000004997.Peer-Reviewed Original ResearchConceptsPrenatal risk factorsRisk factorsGestational diabetesPerinatal complicationsNonsyndromic craniosynostosisPremature suture fusionNormal birthCraniosynostosis patientsDuke University Health SystemIntrauterine risk factorsNorth Carolina State CenterPerinatal risk factorsIntrauterine growth restrictionUniversity Health SystemSuture fusionNonsyndromic craniosynostosis patientsPrenatal diagnostic toolMaternal comorbiditiesCesarean sectionBreech presentationPrimary outcomeHead traumaBirth complicationsCesarean birthControl cohortRate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction.
Elsamadicy AA, Lubkin DT, Sergesketter AR, Adil SM, Charalambous LT, Drysdale N, Williamson T, Camara-Quintana J, Abd-El-Barr MM, Goodwin CR, Karikari IO. Rate of instrumentation changes on postoperative and follow-up radiographs after primary complex spinal fusion (five or more levels) for adult deformity correction. Journal Of Neurosurgery Spine 2019, 30: 376-381. PMID: 30641841, DOI: 10.3171/2018.9.spine18686.Peer-Reviewed Original ResearchConceptsPrimary complex spinal fusionComplex spinal fusionSpinal fusionSpine surgeryDeformity correctionAdult deformity correctionCost-conscious healthcareMethodsThe medical recordsPostoperative complication rateMean lengthBody mass indexFollow-up radiographsRevision of surgeryComplex spine surgeryMajor academic institutionHospital stayAdult patientsComplication ratePatient demographicsReadmission ratesBlood lossPrimary outcomeMass indexEarly radiographsPostoperative radiographs
2018
Correlation of 2-year SRS-22r and ODI patient-reported outcomes with 5-year patient-reported outcomes after complex spinal fusion: a 5-year single-institution study of 118 patients.
Adogwa O, Karikari IO, Elsamadicy AA, Sergesketter AR, Galan D, Bridwell KH. Correlation of 2-year SRS-22r and ODI patient-reported outcomes with 5-year patient-reported outcomes after complex spinal fusion: a 5-year single-institution study of 118 patients. Journal Of Neurosurgery Spine 2018, 29: 422-428. PMID: 29979138, DOI: 10.3171/2018.2.spine171142.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesComplex spinal fusionSpinal fusionLong-term patient-reported outcomesBaseline patient-reported outcomesMental healthSRS-22r domainsSingle-institution studyLack of patientsSRS-22rAdult patientsAmbispective studyIntraoperative variablesPatient demographicsPrimary outcomeGreater absolute changeRevision surgeryRadiographic parametersProspective collectionCobb angleSpinal arthrodesisIliac fixationPatientsPRO dataPRO instrumentsPost-operative drain use in patients undergoing decompression and fusion: incidence of complications and symptomatic hematoma
Adogwa O, Elsamadicy AA, Sergesketter AR, Shammas RL, Vatsia S, Vuong VD, Khalid S, Cheng J, Bagley CA, Karikari IO. Post-operative drain use in patients undergoing decompression and fusion: incidence of complications and symptomatic hematoma. Journal Of Spine Surgery 2018, 4: 220-226. PMID: 30069510, PMCID: PMC6046317, DOI: 10.21037/jss.2018.05.09.Peer-Reviewed Original ResearchSurgical site infectionPost-operative complicationsBody mass indexHematoma formationSpinal decompressionPatient demographicsSubfascial drainsPost-operative complication rateSuperficial surgical site infectionAdult spinal deformity patientsPost-operative drainPostoperative complication profileIncidence of complicationsHospital readmission ratesSpinal deformity patientsMajor academic institutionSymptomatic hematomaHospital stayReadmission ratesComplication rateDrain usePrimary outcomeSite infectionOperative timeUse cohortPreoperative Hemoglobin Level is Associated with Increased Health Care Use After Elective Spinal Fusion (≥3 Levels) in Elderly Male Patients with Spine Deformity
Elsamadicy AA, Adogwa O, Ongele M, Sergesketter AR, Tarnasky A, Lubkin DET, Drysdale N, Cheng J, Bagley CA, Karikari IO. Preoperative Hemoglobin Level is Associated with Increased Health Care Use After Elective Spinal Fusion (≥3 Levels) in Elderly Male Patients with Spine Deformity. World Neurosurgery 2018, 112: e348-e354. PMID: 29355811, DOI: 10.1016/j.wneu.2018.01.046.Peer-Reviewed Original ResearchConceptsElderly male patientsPreoperative Hgb levelsElective spinal fusionHealth care useHgb levelsSpinal fusionMale patientsPostoperative deliriumHemoglobin levelsCare useMean Hgb levelsNon-wound infectionsPreoperative hemoglobin levelLower hemoglobin levelsLower Hgb levelsQuality of careMajor academic institutionPreoperative HgbHospital stayPreoperative levelsPrimary outcomePreoperative identificationHematoma formationMedical recordsSpine surgery
2017
Drivers and Risk Factors of Unplanned 30‐Day Readmission Following Spinal Cord Stimulator Implantation
Elsamadicy AA, Sergesketter A, Ren X, Hussaini S, Laarakker A, Rahimpour S, Ejikeme T, Yang S, Pagadala P, Parente B, Xie J, Lad SP. Drivers and Risk Factors of Unplanned 30‐Day Readmission Following Spinal Cord Stimulator Implantation. Neuromodulation Technology At The Neural Interface 2017, 21: 87-92. PMID: 28961362, PMCID: PMC5766416, DOI: 10.1111/ner.12689.Peer-Reviewed Original ResearchConceptsSpinal cord stimulator implantationSCS implantationUnplanned readmissionIndependent predictorsPatient demographicsReadmission ratesMechanical complicationsStimulator implantationBaseline patient demographicsNational Readmission DatabaseReadmission statusNational healthcare expendituresPrimary outcomeHospital characteristicsRisk factorsPatient outcomesReadmissionMultivariate analysisPatientsSCS deviceHealthcare expendituresComorbiditiesImplantationComplicationsObesityImpact of alcohol use on 30-day complication and readmission rates after elective spinal fusion (≥2 levels) for adult spine deformity: a single institutional study of 1,010 patients
Elsamadicy AA, Adogwa O, Vuong VD, Sergesketter A, Reddy G, Cheng J, Bagley CA, Karikari IO. Impact of alcohol use on 30-day complication and readmission rates after elective spinal fusion (≥2 levels) for adult spine deformity: a single institutional study of 1,010 patients. Journal Of Spine Surgery 2017, 3: 403-410. PMID: 29057350, PMCID: PMC5637196, DOI: 10.21037/jss.2017.08.12.Peer-Reviewed Original ResearchElective spinal fusionReadmission ratesSpinal fusionAlcohol useAdult patientsComplication rateSpinal deformityPostoperative complication profilePreoperative alcohol usePostoperative complication ratePost-operative complicationsSingle institutional studyAdult spine deformitySpinal fusion surgeryHistory of alcoholSignificant differencesMajor academic institutionElective correctionBaseline characteristicsPostoperative complicationsIntraoperative variablesPrimary outcomeComplication profileSurgical outcomesFusion surgeryRelationship Among Koenig Depression Scale and Postoperative Outcomes, Ambulation, and Perception of Pain in Elderly Patients (≥65 Years) Undergoing Elective Spinal Surgery for Adult Scoliosis
Adogwa O, Elsamadicy AA, Sergesketter AR, Black C, Tarnasky A, Ongele MO, Vuong VD, Khalid S, Cheng J, Bagley CA, Karikari IO. Relationship Among Koenig Depression Scale and Postoperative Outcomes, Ambulation, and Perception of Pain in Elderly Patients (≥65 Years) Undergoing Elective Spinal Surgery for Adult Scoliosis. World Neurosurgery 2017, 107: 471-476. PMID: 28826716, DOI: 10.1016/j.wneu.2017.07.165.Peer-Reviewed Original ResearchConceptsElective spinal surgeryAmbulation abilityElderly patientsHospital dischargeComplication rateHospital stayPostoperative outcomesVAS scoresSpinal surgeryDepression ScaleVisual analog scale scoreSignificant differencesElective spine surgeryInferior postoperative outcomesPreoperative gait speedAnalog scale scoreDepressed elderly patientsPatient-reported outcomesAdult degenerative scoliosisPerception of painBoard-certified geriatriciansPostoperative complicationsBaseline demographicsIntraoperative variablesPrimary outcomeReduced Impact of Smoking Status on 30-Day Complication and Readmission Rates After Elective Spinal Fusion (≥3 Levels) for Adult Spine Deformity: A Single Institutional Study of 839 Patients
Elsamadicy AA, Adogwa O, Sergesketter A, Vuong VD, Lydon E, Behrens S, Cheng J, Bagley CA, Karikari IO. Reduced Impact of Smoking Status on 30-Day Complication and Readmission Rates After Elective Spinal Fusion (≥3 Levels) for Adult Spine Deformity: A Single Institutional Study of 839 Patients. World Neurosurgery 2017, 107: 233-238. PMID: 28790002, DOI: 10.1016/j.wneu.2017.07.174.Peer-Reviewed Original ResearchConceptsReadmission ratesSmoking statusComplex spinal fusionSpinal fusionPostoperative complicationsPatient demographicsComplication rateSimilar postoperative complication ratesAdult spinal deformity patientsPostoperative complication rateSingle institutional studyBody mass indexElective spinal fusionPatients' smoking statusAdult spine deformitySpinal deformity patientsComplex spinal surgeryMajor academic institutionHospital stayPostoperative outcomesPrimary outcomeWound drainageMass indexOperative timeDeformity patientsIncreased 30-Day Complication Rates Associated with Laminectomy in 874 Adult Patients with Spinal Deformity Undergoing Elective Spinal Fusion: A Single Institutional Study
Elsamadicy AA, Adogwa O, Warwick H, Sergesketter A, Lydon E, Shammas RL, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Increased 30-Day Complication Rates Associated with Laminectomy in 874 Adult Patients with Spinal Deformity Undergoing Elective Spinal Fusion: A Single Institutional Study. World Neurosurgery 2017, 102: 370-375. PMID: 28359921, DOI: 10.1016/j.wneu.2017.03.096.Peer-Reviewed Original ResearchConceptsElective spinal fusionSpinal fusionSpinal deformityAdult patientsComplication rateComplication Rates AssociatedAllogeneic blood transfusionPostoperative complication rateSingle institutional studyUrinary tract infectionHigh complication rateIntensive care unitMajor academic institutionPatient demographicsReadmission ratesTract infectionsBlood lossBlood transfusionPrimary outcomeWound drainageCare unitIntraoperative durotomyMedical recordsMental statusInstrumentation failureEffect of employment status on length of hospital stay, 30-day readmission and patient reported outcomes after spine surgery
Adogwa O, Elsamadicy AA, Fialkoff J, Mehta AI, Vasquez RA, Cheng J, Karikari IO, Bagley CA. Effect of employment status on length of hospital stay, 30-day readmission and patient reported outcomes after spine surgery. Journal Of Spine Surgery 2017, 3: 44-49. PMID: 28435917, PMCID: PMC5386895, DOI: 10.21037/jss.2017.03.08.Peer-Reviewed Original ResearchElective spine surgeryHospital staySpine surgeryReadmission ratesComplication ratePatient cohortFunctional improvementPeri-operative complication ratesPost-operative complication rateEmployment statusUnplanned hospital readmissionDays of dischargeGreater functional improvementMajor academic medical centerAcademic medical centerCause readmissionBaseline characteristicsPatient demographicsBlood lossHospital readmissionPrimary outcomeReadmission preventionUnemployed patientsOperative timeMedical recordsImpact of surgical approach on complication rates after elective spinal fusion (≥3 levels) for adult spine deformity
Elsamadicy AA, Adogwa O, Behrens S, Sergesketter A, Chen A, Mehta AI, Vasquez RA, Cheng J, Bagley CA, Karikari IO. Impact of surgical approach on complication rates after elective spinal fusion (≥3 levels) for adult spine deformity. Journal Of Spine Surgery 2017, 3: 31-37. PMID: 28435915, PMCID: PMC5386906, DOI: 10.21037/jss.2017.03.09.Peer-Reviewed Original ResearchElective spinal fusionAnterior/posterior approachAdult spine deformityPosterior approachSurgical approachSpinal fusionComplication ratePatient demographicsSpine deformityPost-operative complication rateAdult spine deformity patientsPost-operative complicationsHigher operative timeDifferent surgical approachesSpine deformity patientsMajor academic institutionRate of intraHigher EBLBlood transfusionPrimary outcomeIntraoperative durotomyOperative timeDeformity patientsMedical recordsHigh incidence