2024
Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments
Armbruster‐Genç D, Neil L, Valton V, Phillips H, Rankin G, Sharp M, Rapley J, Viding E, Roiser J, McCrory E. Childhood maltreatment is associated with lower exploration and disrupted prefrontal activity and connectivity during reward learning in volatile environments. Journal Of Child Psychology And Psychiatry 2024 PMID: 39665511, DOI: 10.1111/jcpp.14095.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingReward learningOrbitofrontal cortexChildhood maltreatmentProbabilistic reinforcement learning taskDocumented history of maltreatmentAtypical reward processingOrbitofrontal cortex connectivityNon-maltreated individualsLower exploratory behaviorMid-cingulate cortexDisrupt neural processingHistory of maltreatmentImpact of maltreatmentReinforcement learning taskPrefrontal activationReward processingReward contingenciesNeural indicesOutcome deliveryNeural signalsLatent vulnerabilityBehavioral measuresInternalising symptomsOutcome processing
2022
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2018
Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms
Sethi A, McCrory E, Puetz V, Hoffmann F, Knodt A, Radtke S, Brigidi B, Hariri A, Viding E. Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 1013-1021. PMID: 29752216, PMCID: PMC6185817, DOI: 10.1016/j.bpsc.2018.04.002.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexNeurocognitive mechanismsPsychopathic traitsPrimary psychopathySecondary psychopathyCingulate cortexEmotional face processing taskComparison groupDifferent neurocognitive mechanismsDistinct neural correlatesFace processing taskFunctional magnetic resonance imagingInferior parietal lobeVolunteer sampleAnger processingNeurocognitive correlatesInsula activityNeural correlatesNeural responsesAnxiety measuresNeural activationSecondary presentationLower anxietyPsychopathy groupHigh anxiety
2015
Childhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents
Elsey J, Coates A, Lacadie CM, McCrory EJ, Sinha R, Mayes LC, Potenza MN. Childhood Trauma and Neural Responses to Personalized Stress, Favorite-Food and Neutral-Relaxing Cues in Adolescents. Neuropsychopharmacology 2015, 40: 1580-1589. PMID: 25567424, PMCID: PMC4915266, DOI: 10.1038/npp.2015.6.Peer-Reviewed Original ResearchConceptsChildhood traumaPersonalized stressSubjective anxietyFavorite-food cuesFunctional magnetic resonance imagingPhysical health outcomesCortico-limbic circuitryNeural correlatesMotivational stateTrauma exposureNeural responsesFunctional neuroimagingPrefrontal cortexStress cuesAnterior cingulateEmotional disturbanceCerebellar regionsCuesGroup differencesRisky behaviorsBrain regionsAdolescentsSubcortical structuresAnxietyIncreased activation
2013
Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems
Lockwood P, Sebastian C, McCrory E, Hyde Z, Gu X, De Brito S, Viding E. Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems. Current Biology 2013, 23: 901-905. PMID: 23643836, PMCID: PMC3918856, DOI: 10.1016/j.cub.2013.04.018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingConduct problemsNeural responsesAnterior insulaCallous traitsAdult psychopathyReduced blood oxygen level-dependent responsesAtypical neural responsesBlood oxygen level-dependent (BOLD) responseInferior frontal gyrusBilateral anterior insulaLevel-dependent responsesConsiderable societal costsEmpathic processingEmpathic deficitsEmpathic responsesFrontal gyrusAntisocial behaviorCingulate cortexACC responseEmpathyLarge samplePsychopathyNegative associationNeural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levels