Christopher Whitlow, MD, PhD, MHA
Chair, Department of Radiology and Biomedical ImagingAbout
Research
Publications
2026
Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent
Bhoopal B, Gollapelli K, Damuka N, Krizan I, Miller M, Fitzgerald R, Amesar N, Mumbaraddi D, Zhu D, Cervera-Juanes R, Jadiya P, Whitlow C, Sai K. Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent. Journal Of Medicinal Chemistry 2026 PMID: 41851960, DOI: 10.1021/acs.jmedchem.5c03351.Peer-Reviewed Original ResearchAlzheimer's diseaseG protein-coupled receptorsComprehensive preclinical evaluationExtracellular zinc ionsAD miceMetabolic processesGPR39 knockoutNeurodegenerative diseasesPreclinical assessmentPET imaging agentPreclinical evaluationAutoradiography analysisGPR39Treatment monitoringBrain uptakeDisease processFat tissueNeurological disordersDrug developmentDiseaseImaging agentsZinc ionsCurrent State of Artificial Intelligence Adoption and Implementation in Neuroradiology Departments: Insights from a U.S. National Survey.
Wintermark M, Allen J, Bhala R, Derdeyn C, Gupta A, Hess C, Hoxworth J, Huisman T, Jayaraman M, Malhotra A, McKinney A, Mossa-Basha M, Policeni B, Poussaint T, Saindane A, Vagal A, Whitlow C. Current State of Artificial Intelligence Adoption and Implementation in Neuroradiology Departments: Insights from a U.S. National Survey. American Journal Of Neuroradiology 2026, ajnr.a9279. PMID: 41791836, DOI: 10.3174/ajnr.a9279.Peer-Reviewed Original ResearchArtificial intelligenceImage quality enhancementTransformed medical imageAI useArtificial intelligence adoptionMedical imagesAI potentialReport generationAI usageMulti-selectionCross-sectional survey questionnaireQuality enhancementIntegration challengesFalse positivesWorkloadSurvey-based studyDescriptive statisticsU.S. National SurveyOpen-ended formatNational surveyNeuroradiology departmentImagesEfficacy evidenceSurvey questionnaireClinical toolImpact of Imaging Acquisition and Protocol Variability on Artificial Intelligence Model Performance: A Secondary Analysis of the ASFNR Artificial Intelligence Competition.
Zhu G, Ozkara B, Allen J, Barboriak D, Chaudhari R, Chen H, Chukus A, Etter M, Filippi C, Flanders A, Godwin R, Hashmi S, Hess C, Hsu K, Jiang B, Lui Y, Maldjian J, Michel P, Nalawade S, Raghavan P, Sair H, Welker K, Whitlow C, Zaharchuk G, Wintermark M. Impact of Imaging Acquisition and Protocol Variability on Artificial Intelligence Model Performance: A Secondary Analysis of the ASFNR Artificial Intelligence Competition. American Journal Of Neuroradiology 2026, ajnr.a9266. PMID: 41760384, DOI: 10.3174/ajnr.a9266.Peer-Reviewed Original ResearchIntracranial hemorrhageAcute ischemic strokeAssociated with detectionIschemic strokeSlice thicknessMass effectGeneralized Estimating EquationsNoncontrast head CT scansSecondary analysisHead CT scanAI modelsScanner manufacturersProtocol variablesArtificial intelligenceDetection of intracranial hemorrhageCT scanArtificial intelligence competitionHemorrhageImage acquisitionAI model performanceAI competitionUnderstanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis.
Bell N, Xi Y, Cardoso da Fonseca N, Urban J, Powers A, Wagner B, Whitlow C, Proskovec A, Stitzel J, Yu F, Maldjian J, Davenport E. Understanding the Neural Connectivity Changes of Repetitive Head Impacts in Youth Football Players: A Cross-Sectional MEG Analysis. Brain Connectivity 2026, 21580014261425220. PMID: 41709584, DOI: 10.1177/21580014261425220.Peer-Reviewed Original ResearchLong-term effectsAnalysis of covarianceDelta frequency bandNo significant differenceEffect of RhyFollow-upFootball playersBeta frequency bandsAdvanced neuroimaging techniquesFunctional brain changesDevelopmental age groupsSignificant differenceClinical toolControl groupCompensatory mechanismsAge groupsMultiple comparisonsBrain changesNeurological conditionsNeural connectivity changesMagnetoencephalography scansCortical regionsMEG analysisYouth football playersContact sportsTotal-body irradiation reduces cerebrovascular reactivity (CVR) in rhesus macaques (Macaca mulatta)
Johnson B, Lipford M, Barcus R, Schaaf G, Andrews R, Kim J, Olson J, Deycmar S, Reed C, Whitlow C, Cline J. Total-body irradiation reduces cerebrovascular reactivity (CVR) in rhesus macaques (Macaca mulatta). International Journal Of Radiation Oncology • Biology • Physics 2026 PMID: 41690557, DOI: 10.1016/j.ijrobp.2026.01.043.Peer-Reviewed Original ResearchRadiation-induced brain injuryTotal body irradiationCerebral blood flowPartial-body irradiationCerebrovascular reactivityVascular injuryMicrovessel densitySingle dose total body irradiationIrradiated animalsVascular changesRadiation-induced vascular injuryRadiation-induced vascular changesRhesus macaquesPseudo-continuous arterial spin labelingFrontal lobeMagnetic resonance imagingArterial spin labelingLong-term cognitive declineAge of malesMacaca mulattaMales aged 7Resonance imagingBlood flowSeparate animalsEarly identificationPlasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA
Lockhart S, Sutphen C, Tanley J, Gonzalez‐Ortiz F, Kac P, Habes M, Heckbert S, Ashton N, Mielke M, Koeppe R, Rudolph M, Sai K, Whitlow C, Hiatt K, Craft S, Register T, Hayden K, Rapp S, Sachs B, Zetterberg H, Blennow K, Karikari T, Hughes T. Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA. Alzheimer's & Dementia 2026, 22: e71131. PMID: 41630612, PMCID: PMC12865319, DOI: 10.1002/alz.71131.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseP-tau231P-tau217AD-related pathologyP-tau measuresAmyloid-betaMulti-Ethnic Study of AtherosclerosisPlasma AD biomarkersP-tauLight chainP-tau181Glial fibrillary acidic proteinAD biomarkersAcidic proteinAssociated with white matter hyperintensitiesCognitive statusThreonine 217AlzheimerCerebral small vessel diseaseWhite matter hyperintensitiesPET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys
Bhoopal B, Frye B, Miller M, Bansode A, Gollapelli K, Barcus R, Lockhart S, Damuka N, Sutphen C, Fitzgerald R, Kim J, Baxter M, Jorgensen M, Craft S, Register T, Whitlow C, Shively C, Solingapuram Sai K. PET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys. Journal Of Translational Medicine 2026, 24: 42. PMID: 41501910, PMCID: PMC12784507, DOI: 10.1186/s12967-025-07642-5.Peer-Reviewed Original ResearchBrain regionsCerebrospinal fluidTracer uptakePET radiotracersVervet monkeysAnterior cingulate gyrusTracer bindingWidespread cortical distributionCingulate gyrusNeurofilament light chainTemporal lobeNon-human primatesCerebrospinal fluid NfLCerebrospinal fluid pTau181PET/MRI imagingBrain uptakeCortical distributionSignificant positive correlationHuman studiesOccipital lobePositive correlationBiomarker correlationsEffective interventionsConclusionsThese findingsMethodsThis study
2025
Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players
Yu K, Wiesman A, Davenport E, Flashman L, Urban J, Nagarajan S, Sai K, Stitzel J, Maldjian J, Whitlow C. Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players. IScience 2025, 29: 114575. PMID: 41623461, PMCID: PMC12856156, DOI: 10.1016/j.isci.2025.114575.Peer-Reviewed Original ResearchSuperior frontal cortexResting-state magnetoencephalographyCognitive concernsCognitive symptomsFrontal cortexCortical excitabilityGamma powerNeurophysiological disturbancesNeurophysiological activityAssociated with higher ratesAssociated with clinical outcomesCortexConcussionMagnetoencephalographyDebilitating clinical symptomsAperiodic exponentAmerican tackle footballNeurophysiologySymptomsClinical outcomesAdolescent football playersClinical symptomsTackle footballHigher RatesFootball playersComparative Analysis of AI-based Quantification vs. Visual Rating of Enlarged Perivascular Spaces in the MESA Cohort.
Torres M, Charisis S, Rashid T, Brandigampala S, Hiatt K, Ware J, Whitlow C, Nasrallah I, Romero J, Tanley J, Seshadri S, Hohman T, Heckbert S, Davatzikos C, Hughes T, Habes M. Comparative Analysis of AI-based Quantification vs. Visual Rating of Enlarged Perivascular Spaces in the MESA Cohort. American Journal Of Neuroradiology 2025, ajnr.a9129. PMID: 41397892, DOI: 10.3174/ajnr.a9129.Peer-Reviewed Original ResearchMulti-Ethnic StudyMulti-Ethnic Study of AtherosclerosisVascular risk factorsCross-sectional studyStudy of atherosclerosisSystolic blood pressureRisk factorsWaist-to-hip ratioAssociated with higher systolic blood pressureDomain-specific cognitive scoresAssociation of perivascular spacesHigher systolic blood pressurePoorer global cognitionAssociated with older ageLarge-scale epidemiological dataOrdinal logistic regressionCognitive performanceBlood pressureWhite race/ethnicityGlobal cognitionOdds ratioSelf-ReportBasal gangliaLogistic regressionDemographic characteristicsAPOE ε4 Modulates Beta‐Amyloid Clearance via Cerebrospinal Fluid Dynamics: Insights from Nonhuman Primate and Clinical Studies
Kim J, Lipford M, Barcus R, Yuan H, Lyu Q, Hudson J, Lockhart S, Hughes T, Sutphen C, Frye B, Sai K, Rudolph M, Shively C, Register T, Mielke M, Craft S, Whitlow C. APOE ε4 Modulates Beta‐Amyloid Clearance via Cerebrospinal Fluid Dynamics: Insights from Nonhuman Primate and Clinical Studies. Alzheimer's & Dementia 2025, 21: e104986. PMCID: PMC12780961, DOI: 10.1002/alz70856_104986.Peer-Reviewed Original ResearchCerebrospinal fluid flow dynamicsCerebrospinal fluid flowCerebrospinal fluidPositron emission tomographyNon-carriersStandardized uptake value ratioClinical studiesClinical cohortCerebellomedullary cisternNonhuman primatesPontine cisternImpaired CSF dynamicsClearance mechanismsNonhuman primate modelAge-adjusted analysesNonhuman primate studiesCerebrospinal fluid dynamicsSpinal canalCerebral aqueductDisease progressionPlasma biomarkersTherapeutic strategiesImpaired clearanceCSF flowClearance differences
Academic Achievements & Community Involvement
News
News
- March 24, 2026
AI in Cancer Workshop: Advancing Precision Medicine through Interdisciplinary Innovation
- December 01, 2025
Christopher Whitlow on the Research and Practice—and Creativity—of Radiology
- July 31, 2025
Christopher Whitlow, MD, PhD, MHA, to be Appointed Chair, Department of Radiology and Biomedical Imaging