2023
The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps
Meyerson W, Fineberg S, Andrade F, Corlett P, Gerstein M, Hoyle R. The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps. Sleep Medicine 2023, 107: 212-218. PMID: 37235891, DOI: 10.1016/j.sleep.2023.04.021.Peer-Reviewed Original ResearchConceptsSocial media useDelayed sleep onsetSelf-reported sleep patternsMedia useIndividual differencesDelayed sleepInsufficient sleepSleep onsetSleep patternsReddit usersSleepSocial media usageBedtimeSocial media usersAdditional supportOnset of sleepSocial mediaCausal effectMedia usageCausal relationshipPublic health officialsMedia usersPerceptionSuggestive evidenceRedditA pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Fineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.Peer-Reviewed Original ResearchConceptsBorderline personality disorderSecondary outcome measuresOutcome measuresSocio-occupational functioningSuicidal ideationPilot studyTrial of ketaminePersonality disorderInfusion of ketaminePrimary outcome measureEffects of ketamineMidazolam groupAdverse eventsKetamine groupClinical benefitMood symptomsKetamineFDA approvalDrug midazolamInfusionBPD symptomsLarger studyDepressed moodSymptomsChronic mood
2012
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsBrainCognitionDouble-Blind MethodExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousKetamineMagnetic Resonance ImagingMaleMemoryModels, NeurologicalPattern Recognition, VisualPsychomotor PerformanceReceptors, N-Methyl-D-AspartateSchizophreniaSynaptic TransmissionYoung AdultConceptsNeural systemsLarge-scale brain systemsTask-dependent activationN-methyl-D-aspartate receptorsRealistic computational modelingSevere neuropsychiatric illnessNMDA glutamate receptor antagonistGlutamate receptor antagonistsBrain systemsNMDA receptor functionTask performanceMultiple interacting regionsCognitionCortical disinhibitionGlutamatergic neurotransmissionReceptor antagonistCortical computationGlutamate's roleReciprocal relationshipNeuropsychiatric illnessLocal circuitsReceptor functionSchizophreniaPresent findingsComputational modeling
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividualsSubstantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray G, Corlett P, Clark L, Pessiglione M, Blackwell A, Honey G, Jones P, Bullmore E, Robbins T, Fletcher P. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 2007, 13: 267-276. PMID: 17684497, PMCID: PMC2564111, DOI: 10.1038/sj.mp.4002058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCase-Control StudiesChoice BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, PsychologicalNeuropsychological TestsOxygenPhotic StimulationPsychiatric Status Rating ScalesPsychotic DisordersRewardSubstantia NigraVentral Tegmental AreaConceptsDopaminergic midbrainFunctional magnetic resonance imagingReward prediction errorHealthy control participantsPsychosis patientsNeutral stimuliMotivational salienceNeural responsesMental experienceRecent theoretical interestFirst-episode psychosis patientsPrediction errorConditioning experimentsControl participantsEpisode psychosis patientsPsychotic experiencesPathophysiology of schizophreniaPositive symptomsAbnormal physiological responsesMesolimbic activityMidbrain dopamine neuronsMagnetic resonance imagingDopamine dysfunctionDopamine systemDopamine neuronsPredictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers
Absalom A, Lee M, Menon D, Sharar S, De Smet T, Halliday J, Ogden M, Corlett P, Honey G, Fletcher P. Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers. British Journal Of Anaesthesia 2007, 98: 615-623. PMID: 17389691, PMCID: PMC3838936, DOI: 10.1093/bja/aem063.Peer-Reviewed Original ResearchConceptsTarget-controlled infusionKetamine infusionHealthy volunteersLow-dose ketamine infusionPlasma concentration-time courseVenous blood samplesCognitive function testsConcentration-time courseFunction testsKetamine administrationTarget concentrationBlood samplesKetamine modelInfusionMore occasionsTCI deviceFunctional neuroimagingVolunteers
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects
2005
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Honey G, Pomarol-Clotet E, Corlett P, Honey R, Mckenna P, Bullmore E, Fletcher P. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 2005, 128: 2597-2611. PMID: 16183659, PMCID: PMC3838931, DOI: 10.1093/brain/awh632.Peer-Reviewed Original ResearchConceptsCognitive dysmetria hypothesisPatient groupAnterior cingulateFunctional MRIContinuous performance taskFunctional dysconnectivitySchizophrenia patientsPositive symptomsNegative symptomsMedial superior frontal gyrusThalamo-cortical circuitsDistinct symptom profilesSupplementary motor areaCases of schizophreniaSuperior frontal gyrusFunctional imaging studiesTask-related connectivityGroups of subjectsIllness onsetControl subjectsFunctional deficitsMotor functionHealthy volunteersMotor areaFundamental abnormality
2004
Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning
CORLETT P, AITKEN M, DICKINSON A, SHANKS D, HONEY G, HONEY R, ROBBINS T, BULLMORE E, FLETCHER P. Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. DOI: 10.1016/s0896-6273(04)00756-1.Peer-Reviewed Original ResearchPrediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning
Corlett P, Aitken M, Dickinson A, Shanks D, Honey G, Honey R, Robbins T, Bullmore E, Fletcher P. Prediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. PMID: 15572117, DOI: 10.1016/j.neuron.2004.11.022.Peer-Reviewed Original ResearchConceptsRetrospective revaluationPrefrontal cortexAssociative accountRight lateral PFC activationRight lateral prefrontal cortexLate brain responsesAssociative learning theoryLateral PFC activationLateral prefrontal cortexRight prefrontal cortexVentral striatal activationPrediction errorAssociative theoryPFC activationBrain responsesFunctional neuroimagingStriatal activationAssociative modelPC theoryAssociative viewLearning phenomenonLearning theoryContrast theoryLearningCuesOn the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning
Fletcher P, Zafiris O, Frith C, Honey R, Corlett P, Zilles K, Fink G. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning. Cerebral Cortex 2004, 15: 1002-1015. PMID: 15537672, PMCID: PMC3838938, DOI: 10.1093/cercor/bhh201.Peer-Reviewed Original ResearchConceptsImplicit learningFunctional magnetic resonance imaging studyExplicit memory processesExpression of learningRight frontal activationLearning-related changesMedial temporal lobeMagnetic resonance imaging studyImplicit sequenceResonance imaging studyBrain basisFrontal activationNeural basisMemory processesSequence difficultyMotor sequenceBrain activityBehavioral experimentsTemporal lobeBehavioral effectsLearningExplicit attemptSubjective intentionAutomatic learningImaging studies