2023
Excessive teleological thinking is driven by aberrant associations and not by failure of reasoning
Ongchoco J, Castiello S, Corlett P. Excessive teleological thinking is driven by aberrant associations and not by failure of reasoning. IScience 2023, 26: 107643. PMID: 37705957, PMCID: PMC10495659, DOI: 10.1016/j.isci.2023.107643.Peer-Reviewed Original ResearchAssociative learningTeleological thinkingCausal learning taskDelusion-like ideasFailure of reasoningCausal learningLearning taskLearningThinkingPrediction errorFundamental distinctionAberrant associationComputational modelingTeleological tendencyTaskReasoningTendencyDifferent instancesMeaningNew understandingObjectsDistinctionRelationshipEvents
2010
Toward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
Why Do Delusions Persist?
Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.Peer-Reviewed Original ResearchFrom drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividuals
2005
Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens
Dalley J, Lääne K, Theobald D, Armstrong H, Corlett P, Chudasama Y, Robbins T. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 6189-6194. PMID: 15833811, PMCID: PMC556132, DOI: 10.1073/pnas.0502080102.Peer-Reviewed Original ResearchConceptsAppetitive Pavlovian learningEarly memory consolidationNMDA receptor antagonistNucleus accumbensPavlovian memoryPavlovian learningAppetitive learningAssociative processesMemory consolidationApproach behaviorInstrumental learningPavlovian conditioningAppetitive memoryFood rewardReceptor antagonistConditioning sessionsNMDA receptorsSpatial learningInstrumental processesGlutamatergic influencesEarly consolidationD2 receptor antagonist sulpirideReceptor antagonist sulpirideIntra-NAc infusionsLearning
2004
Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning
CORLETT P, AITKEN M, DICKINSON A, SHANKS D, HONEY G, HONEY R, ROBBINS T, BULLMORE E, FLETCHER P. Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. DOI: 10.1016/s0896-6273(04)00756-1.Peer-Reviewed Original ResearchPrediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning
Corlett P, Aitken M, Dickinson A, Shanks D, Honey G, Honey R, Robbins T, Bullmore E, Fletcher P. Prediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. PMID: 15572117, DOI: 10.1016/j.neuron.2004.11.022.Peer-Reviewed Original ResearchConceptsRetrospective revaluationPrefrontal cortexAssociative accountRight lateral PFC activationRight lateral prefrontal cortexLate brain responsesAssociative learning theoryLateral PFC activationLateral prefrontal cortexRight prefrontal cortexVentral striatal activationPrediction errorAssociative theoryPFC activationBrain responsesFunctional neuroimagingStriatal activationAssociative modelPC theoryAssociative viewLearning phenomenonLearning theoryContrast theoryLearningCuesOn the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning
Fletcher P, Zafiris O, Frith C, Honey R, Corlett P, Zilles K, Fink G. On the Benefits of not Trying: Brain Activity and Connectivity Reflecting the Interactions of Explicit and Implicit Sequence Learning. Cerebral Cortex 2004, 15: 1002-1015. PMID: 15537672, PMCID: PMC3838938, DOI: 10.1093/cercor/bhh201.Peer-Reviewed Original ResearchConceptsImplicit learningFunctional magnetic resonance imaging studyExplicit memory processesExpression of learningRight frontal activationLearning-related changesMedial temporal lobeMagnetic resonance imaging studyImplicit sequenceResonance imaging studyBrain basisFrontal activationNeural basisMemory processesSequence difficultyMotor sequenceBrain activityBehavioral experimentsTemporal lobeBehavioral effectsLearningExplicit attemptSubjective intentionAutomatic learningImaging studies