2021
Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
Clausen AN, Fercho KA, Monsour M, Disner S, Salminen L, Haswell CC, Rubright EC, Watts AA, Buckley MN, Maron-Katz A, Sierk A, Manthey A, Suarez-Jimenez B, Olatunji BO, Averill CL, Hofmann D, Veltman DJ, Olson EA, Li G, Forster GL, Walter H, Fitzgerald J, Théberge J, Simons JS, Bomyea JA, Frijling JL, Krystal JH, Baker JT, Phan KL, Ressler K, Han LKM, Nawijn L, Lebois LAM, Schmaal L, Densmore M, Shenton ME, van Zuiden M, Stein M, Fani N, Simons RM, Neufeld RWJ, Lanius R, van Rooij S, Koch SBJ, Bonomo S, Jovanovic T, deRoon-Cassini T, Ely TD, Magnotta VA, He X, Abdallah CG, Etkin A, Schmahl C, Larson C, Rosso IM, Blackford JU, Stevens JS, Daniels JK, Herzog J, Kaufman ML, Olff M, Davidson RJ, Sponheim SR, Mueller SC, Straube T, Zhu X, Neria Y, Baugh LA, Cole JH, Thompson PM, Morey RA. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups. Brain And Behavior 2021, 12: e2413. PMID: 34907666, PMCID: PMC8785613, DOI: 10.1002/brb3.2413.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderEffects of PTSDBrain-PADBrain ageMale controlsOld maleStress disorderAge-related brain changesStructural magnetic resonance imagingBrain structural magnetic resonance imagingOlder age groupsMagnetic resonance imagingChronological ageSubset of controlsContext of PTSDControl subjectsBrain changesBrain agingFuture longitudinal researchTreatment approachesLinear mixed effects modelsAdult subjectsResonance imagingAge groupsPTSD assessment
2017
Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans
Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress 2017, 1: 2470547017744538. PMID: 29520395, PMCID: PMC5839647, DOI: 10.1177/2470547017744538.Peer-Reviewed Original ResearchPosttraumatic stress disorderBeck Depression Inventory scoresClinician-Administered PTSD ScaleCornu ammonis 4Depression Inventory scoresHippocampal subfieldsSymptom severityStress disorderPTSD ScaleAlcohol/substance use disorderHippocampal subfield volume lossHigh-resolution structural magnetic resonance imagingInventory scoresAnterior hippocampal regionsStructural magnetic resonance imagingDepressive symptom severityPrefrontal-amygdala circuitrySubstance use disordersBeck Depression InventoryDepression symptom severityMagnetic resonance imagingPosttraumatic stress disorder groupPosttraumatic stress disorder (PTSD) symptomsCombat-exposed veteransFuture confirmatory studies
2006
Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study
Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, Rapid-Cycling, and Pharmacotherapy Effects on Ventral Prefrontal Cortex in Bipolar Disorder: A Cross-Sectional Study. Biological Psychiatry 2006, 59: 611-618. PMID: 16414030, DOI: 10.1016/j.biopsych.2005.08.031.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsWhite matter volumeMagnetic resonance imagingMatter volumeBD patientsHigh-resolution structural magnetic resonance imagingYoung adulthoodStructural magnetic resonance imagingTotal brain volumeCross-sectional studyGray matter volumeAge group interactionVentral prefrontal cortexPharmacotherapy effectsPrefrontal cortex functionIllness featuresBD IProtective effectVolume abnormalitiesHC subjectsComparison subjectsBrain volumeVolume deficitsBipolar disorderRapid initial decline