2022
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits
Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.Peer-Reviewed Original ResearchConceptsLocal genetic correlationsCell type-specific expressionVanderbilt University biorepositoryMulti-omics studiesMulti-omics investigationsDorsolateral prefrontal cortex tissueGenomic evidenceLaboratory traitsSpecific expressionCardio-metabolic traitsMillion Veteran ProgramPrefrontal cortex tissueMiR-148GenesGenetic correlationsRegulatory profileTraitsProtein expressionCardiometabolic traitsExpressionVeteran ProgramCortex tissueBiological heterogeneitySplicingPrioritization approach
2016
Genome-wide significant loci for addiction and anxiety
Hodgson K, Almasy L, Knowles EE, Kent JW, Curran JE, Dyer TD, Göring HH, Olvera RL, Fox PT, Pearlson GD, Krystal JH, Duggirala R, Blangero J, Glahn DC. Genome-wide significant loci for addiction and anxiety. European Psychiatry 2016, 36: 47-54. PMID: 27318301, PMCID: PMC5483998, DOI: 10.1016/j.eurpsy.2016.03.004.Peer-Reviewed Original ResearchConceptsLinkage scanLinkage signalGenome-wide significant lociSignificant quantitative trait lociGenome-wide linkage scanBivariate linkage scanSignificant positive genetic correlationQuantitative trait lociGene of interestBivariate linkage analysisPositive genetic correlationAddiction phenotypeGenomic lociGenetic architectureTrait lociPleiotropic signalsSignificant lociChromosomal regionsAddiction geneticsGenetic underpinningsLinkage analysisPrevious GWASGenetic correlationsNovel regionRole of genetics