Featured Publications
Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related
Afshar N, Cinotti F, Martin D, Khamassi M, Calu DJ, Taylor JR, Groman SM. Reward-Mediated, Model-Free Reinforcement-Learning Mechanisms in Pavlovian and Instrumental Tasks Are Related. Journal Of Neuroscience 2022, 43: 458-471. PMID: 36216504, PMCID: PMC9864557, DOI: 10.1523/jneurosci.1113-22.2022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, OperantCuesLearningMaleMotivationRatsReinforcement, PsychologyRewardConceptsGoal-tracking behaviorReinforcement learning mechanismInstrumental learning processesSign-tracking behaviorModel-free reinforcementApproach taskInstrumental taskInstrumental behaviorBehavioral proceduresSubjects designLearning mechanismDecision Making TaskModel-based computationLearning processModel-free reinforcement learningPredictive cuesIncentive salienceAssociative learningIndividual differencesComputational mechanismsDecision-making processPavlovianModel-based algorithmValue representationAction valuesReinforcement learning detuned in addiction: integrative and translational approaches
Groman SM, Thompson SL, Lee D, Taylor JR. Reinforcement learning detuned in addiction: integrative and translational approaches. Trends In Neurosciences 2021, 45: 96-105. PMID: 34920884, PMCID: PMC8770604, DOI: 10.1016/j.tins.2021.11.007.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBehavior, AddictiveDecision MakingHumansReinforcement, PsychologySubstance-Related DisordersConceptsDecision-making deficitsPathophysiology of addictionDecision-making strategiesBiobehavioral mechanismsAddictionReinforcement learningDecision-making processDrug useTranslational approachComputational componentsDeficitsLearningDifferent componentsBiological mechanismsOutcomesFindingsRecent studiesBehaviorStudyReinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsConditioning, OperantFemaleHumansMaleRatsRats, Long-EvansReinforcement, PsychologyReversal LearningConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodUnlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex
Groman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBehavior, AddictiveNeurosciencesPrefrontal CortexReinforcement, PsychologyConceptsOrbitofrontal cortexReinforcement-learning mechanismsDecision-making impairmentsDiverse clinical populationsDecision-making differsNeurocomputational approachOFC dysfunctionNeuroscience techniquesBiobehavioral disordersBehavioral paradigmsClinical populationsBiobehavioral mechanismsAddiction pathologyComputational differencesReinforcement-learning algorithms
2012
The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity
Olausson P, Venkitaramani D, Moran T, Salter M, Taylor J, Lombroso P. The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity. Neuroscience 2012, 225: 1-8. PMID: 22885232, PMCID: PMC3725644, DOI: 10.1016/j.neuroscience.2012.07.069.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsConditioning, OperantElectric StimulationExcitatory Postsynaptic PotentialsFearMaleMAP Kinase Signaling SystemMemoryMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityPatch-Clamp TechniquesProtein Tyrosine Phosphatases, Non-ReceptorReinforcement ScheduleReinforcement, PsychologyConceptsSynaptic plasticityExperience-dependent synaptic plasticityAspartic acid (NMDA) receptorsMemory formationLong-term potentiationAdult neuroplasticityAmygdala-dependent memory formationPharmacological treatmentKO miceExperience-induced neuroplasticityTyrosine phosphatase STEPNR2B subunitLateral amygdalaBrain regionsTyrosine kinase FynAcid receptorsStriatal-enriched protein tyrosine phosphataseNeuroplasticityMiceERK phosphorylationReceptor internalizationERK signalingKinase 1/2Detectable expressionSTEP KO mice
2009
Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function
Krueger DD, Howell JL, Oo H, Olausson P, Taylor JR, Nairn AC. Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function. Behavioural Pharmacology 2009, 20: 695-704. PMID: 19901826, PMCID: PMC3380449, DOI: 10.1097/fbp.0b013e328333a2bb.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttentionCocaineCocaine-Related DisordersCognitionConditioning, ClassicalConditioning, OperantDisease Models, AnimalImpulsive BehaviorInhibition, PsychologicalInjections, IntraperitonealMaleMemory DisordersMemory, Short-TermMiceMice, Inbred C57BLMotor ActivityReinforcement ScheduleReinforcement, PsychologyReversal LearningTime FactorsConceptsCognitive functionAttentional functionsResponse inhibitionPrefrontal cortexThree-choice serial reaction time taskSerial reaction time taskReaction time taskPattern of errorsCocaine exposureDevelopment of addictionPrior chronic exposureCognitive flexibilityInstrumental reversalTime taskPosition taskChronic cocaine exposureChronic cocaine useCognitive dysfunctionTaskMemoryCocaine useDrug-free periodSuitable animal modelMultiple aspectsCortex
2001
Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats
Jentsch J, Taylor J. Impaired Inhibition of Conditioned Responses Produced by Subchronic Administration of Phencyclidine to Rats. Neuropsychopharmacology 2001, 24: 66-74. PMID: 11106877, DOI: 10.1016/s0893-133x(00)00174-3.Peer-Reviewed Original ResearchConceptsPCP-treated ratsStimulus-reward associationsNovel instrumental responseInhibitory response controlObsessive-compulsive disorderMore responsesConcurrent discriminationReversal learningFrontostriatal systemIncentive stimuliAffective impairmentsInhibitory controlInstrumental respondingImpaired inhibitionConditioned responseInstrumental responsePCP treatmentResponse controlMental disordersCurrent studyDrug abuseStimuliLearningSubchronic administrationImpulsivity
1989
Limbic-striatal interactions in reward-related processes
Robbins T, Cador M, Taylor J, Everitt B. Limbic-striatal interactions in reward-related processes. Neuroscience & Biobehavioral Reviews 1989, 13: 155-162. PMID: 2682402, DOI: 10.1016/s0149-7634(89)80025-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, PsychologicalCorpus StriatumDopamineHumansLimbic SystemMotivationReinforcement, PsychologyRewardConceptsVentral striatumDA depletionIndirect dopamine agonist d-amphetamineStriatal DA depletionReward-related stimuliAgonist d-amphetamineSelective stimulatory effectDA-dependent processesBasolateral nucleusD-amphetamineExcitotoxic lesionsReward-related processesSecond-order scheduleDorsal striatumStriatumAmygdala lesionsStimulatory effectLesionsSimilar discriminative propertiesDiscriminative propertiesOrder schedulePredictive associationsSexual reinforcementDorsalParallel findings