2020
Functional MRI Findings in Schizophrenia
Pearlson G. Functional MRI Findings in Schizophrenia. 2020, 113-124. DOI: 10.1007/978-3-030-35206-6_6.Peer-Reviewed Original ResearchSchizophrenia patientsDrug-naïve patientsFunctional MRI findingsFunctional MRI literatureTask-related paradigmsMRI findingsMedication treatmentPredisposing causeHealthy controlsFunctional abnormalitiesMRI reportsPsychotic bipolarNeurodevelopmental anomaliesPatientsBrain differencesUnaffected relativesSynaptic efficiencySchizophreniaMRI literatureAbnormalitiesArticle reviewsLocal manifestationsReviewSymptomsNeurotransmitters
2017
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
Kelly S, Jahanshad N, Zalesky A, Kochunov P, Agartz I, Alloza C, Andreassen O, Arango C, Banaj N, Bouix S, Bousman C, Brouwer R, Bruggemann J, Bustillo J, Cahn W, Calhoun V, Cannon D, Carr V, Catts S, Chen J, Chen J, Chen X, Chiapponi C, Cho K, Ciullo V, Corvin A, Crespo-Facorro B, Cropley V, De Rossi P, Diaz-Caneja C, Dickie E, Ehrlich S, Fan F, Faskowitz J, Fatouros-Bergman H, Flyckt L, Ford J, Fouche J, Fukunaga M, Gill M, Glahn D, Gollub R, Goudzwaard E, Guo H, Gur R, Gur R, Gurholt T, Hashimoto R, Hatton S, Henskens F, Hibar D, Hickie I, Hong L, Horacek J, Howells F, Hulshoff Pol H, Hyde C, Isaev D, Jablensky A, Jansen P, Janssen J, Jönsson E, Jung L, Kahn R, Kikinis Z, Liu K, Klauser P, Knöchel C, Kubicki M, Lagopoulos J, Langen C, Lawrie S, Lenroot R, Lim K, Lopez-Jaramillo C, Lyall A, Magnotta V, Mandl R, Mathalon D, McCarley R, McCarthy-Jones S, McDonald C, McEwen S, McIntosh A, Melicher T, Mesholam-Gately R, Michie P, Mowry B, Mueller B, Newell D, O'Donnell P, Oertel-Knöchel V, Oestreich L, Paciga S, Pantelis C, Pasternak O, Pearlson G, Pellicano G, Pereira A, Pineda Zapata J, Piras F, Potkin S, Preda A, Rasser P, Roalf D, Roiz R, Roos A, Rotenberg D, Satterthwaite T, Savadjiev P, Schall U, Scott R, Seal M, Seidman L, Shannon Weickert C, Whelan C, Shenton M, Kwon J, Spalletta G, Spaniel F, Sprooten E, Stäblein M, Stein D, Sundram S, Tan Y, Tan S, Tang S, Temmingh H, Westlye L, Tønnesen S, Tordesillas-Gutierrez D, Doan N, Vaidya J, van Haren N, Vargas C, Vecchio D, Velakoulis D, Voineskos A, Voyvodic J, Wang Z, Wan P, Wei D, Weickert T, Whalley H, White T, Whitford T, Wojcik J, Xiang H, Xie Z, Yamamori H, Yang F, Yao N, Zhang G, Zhao J, van Erp T, Turner J, Thompson P, Donohoe G. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry 2017, 23: 1261-1269. PMID: 29038599, PMCID: PMC5984078, DOI: 10.1038/mp.2017.170.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsFractional anisotropyWM skeletonWhite matter microstructural differencesWhite matter abnormalitiesWidespread WM abnormalitiesOnset of schizophreniaAnterior corona radiataEffect sizeDiffusion tensor imaging (DTI) dataTensor imaging dataHealthy controlsMeta-analyzed effectsCorpus callosumMedication dosageCorona radiataPsychiatric disordersLarge effect sizesWM microstructural differencesPatientsWM abnormalitiesRadial diffusivitySchizophreniaSignificant decreaseDiffusivity measures
2016
Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease
Zhang X, Mormino E, Sun N, Sperling R, Sabuncu M, Yeo B, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski D, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D’Agostino D, Kielb S, Sadowski M, Sheikh M, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Gordineer L, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e6535-e6544. PMID: 27702899, PMCID: PMC5081632, DOI: 10.1073/pnas.1611073113.Peer-Reviewed Original ResearchConceptsAtrophy factorAtrophy patternsCortical factorsDementia patientsAlzheimer's disease dementia patientsDistinct atrophy patternsStrong associationEntire clinical spectrumAD dementia patientsExecutive function declineExecutive functionSubcortical factorsFunction declineClinical spectrumEarly ADAlzheimer's diseaseStructural MRIDisease monitoringNormal participantsMemory declineMCI participantsDifferent cognitive domainsPatientsFactor compositionCognitive trajectoriesAccelerating rates of cognitive decline and imaging markers associated with &bgr;-amyloid pathology
Insel P, Mattsson N, Mackin R, Schöll M, Nosheny R, Tosun D, Donohue M, Aisen P, Jagust W, Weiner M, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Green R, Montine T, Petersen R, Aisen P, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Jack C, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Jagust W, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Morris J, Cairns N, Taylor-Reinwald L, Trojanowki J, Shaw L, Lee V, Korecka M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Dolen S, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Ances B, Carroll M, Leon S, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts, CNA P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Coleman R, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Womack K, Mathews D, Quiceno M, Diaz-Arrastia R, King R, Weiner M, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Lu P, Bartzokis G, Silverman D, Graff-Radford, MBBCH N, Parfitt F, Johnson H, Farlow M, Hake A, Matthews B, Herring S, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Robin Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Finger E, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Boles Ponto L, Shim H, Elizabeth Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Ashok Raj B. Accelerating rates of cognitive decline and imaging markers associated with &bgr;-amyloid pathology. Neurology 2016, 86: 1887-1896. PMID: 27164667, PMCID: PMC4873684, DOI: 10.1212/wnl.0000000000002683.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyloid beta-PeptidesAniline CompoundsAtrophyBiomarkersBrainCognitionCognitive DysfunctionDisease ProgressionEthylene GlycolsFemaleFluorodeoxyglucose F18HumansLongitudinal StudiesMagnetic Resonance ImagingMaleMental Status ScheduleNeuropsychological TestsPeptide FragmentsPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisConceptsMild cognitive impairmentFunctional declineNeuronal injuryCSF Aβ42Florbetapir PETAmyloid positivityRate of declineCognitive declineTemporal lobe atrophy ratesΒ-amyloid pathologyEarly Alzheimer's diseaseFluorodeoxyglucose PETAmyloid pathologyFDG-PETFuture trialsAtrophy ratesInclusion criteriaMixed-effects regressionΒ-amyloidCognitive impairmentAlzheimer's diseaseFirst signPatientsInjuryConsiderable proportionSubcortical volumetric abnormalities in bipolar disorder
Hibar DP, Westlye LT, van Erp TG, Rasmussen J, Leonardo CD, Faskowitz J, Haukvik UK, Hartberg CB, Doan NT, Agartz I, Dale AM, Gruber O, Krämer B, Trost S, Liberg B, Abé C, Ekman CJ, Ingvar M, Landén M, Fears SC, Freimer NB, Bearden CE, Sprooten E, Glahn D, Pearlson G, Emsell L, Kenney J, Scanlon C, McDonald C, Cannon D, Almeida J, Versace A, Caseras X, Lawrence N, Phillips M, Dima D, Delvecchio G, Frangou S, Satterthwaite T, Wolf D, Houenou J, Henry C, Malt U, Bøen E, Elvsåshagen T, Young A, Lloyd A, Goodwin G, Mackay C, Bourne C, Bilderbeck A, Abramovic L, Boks M, van Haren N, Ophoff R, Kahn R, Bauer M, Pfennig A, Alda M, Hajek T, Mwangi B, Soares J, Nickson T, Dimitrova R, Sussmann J, Hagenaars S, Whalley H, McIntosh A, Thompson P, Andreassen O. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 2016, 21: 1710-1716. PMID: 26857596, PMCID: PMC5116479, DOI: 10.1038/mp.2015.227.Peer-Reviewed Original ResearchConceptsLateral ventricleBipolar disorderBDII patientsBD patientsIntracranial volumeLarger thalamic volumesSubcortical volumetric abnormalitiesLarger lateral ventriclesSignificant differencesSubcortical brain measuresCase-control differencesDevelopment of biomarkersMean hippocampusVolumetric abnormalitiesIllness onsetThalamic volumeBDI patientsGlobus pallidusSmaller hippocampiClinical subtypesDisease progressionHealthy controlsBrain changesNucleus accumbensPatients
2015
A5006 A double-blind sham/deflation study evaluating reward and somatosensory brain activation after milkshake taste in successful laparoscopic adjustable gastric band patients
Gershfeld K, Ng J, Book G, Stone A, Strange S, Papasavas P, Tishler D, Pearlson G. A5006 A double-blind sham/deflation study evaluating reward and somatosensory brain activation after milkshake taste in successful laparoscopic adjustable gastric band patients. Surgery For Obesity And Related Diseases 2015, 11: s58. DOI: 10.1016/j.soard.2015.08.063.Peer-Reviewed Original ResearchA150 Emotional and Reward Center Brain Activation In Successful Laparoscopic Adjustable Gastric Band (Lagb) Patients: A Double-Blind Sham/Deflation Study
Gershfeld K, Ng J, Book G, Stone A, Strange S, RN C, Papasavas P, Tishler D, Pearlson G. A150 Emotional and Reward Center Brain Activation In Successful Laparoscopic Adjustable Gastric Band (Lagb) Patients: A Double-Blind Sham/Deflation Study. Surgery For Obesity And Related Diseases 2015, 11: s30-s31. DOI: 10.1016/j.soard.2015.10.051.Peer-Reviewed Original ResearchIdentifying Brain Dynamic Network States VIA GIG-ICA: Application to Schizophrenia, Bipolar and Schizoaffective Disorders
Du Y, Pearlson G, He H, Wu L, Chen J, Calhoun V. Identifying Brain Dynamic Network States VIA GIG-ICA: Application to Schizophrenia, Bipolar and Schizoaffective Disorders. 2015, 478-481. DOI: 10.1109/isbi.2015.7163915.Peer-Reviewed Original ResearchFunctional connectivity statesSchizoaffective disorderBipolar disorderSAD patientsDynamic functional networksFunctional networksConnectivity statesResting-state fMRI dataBP patientsHealthy controlsPatientsSZ patientsFunctional connectivitySimilar symptomsFMRI dataDisordersSchizophreniaMental diseasesSignificant differences
2014
P859: Differences in resting-state functional magnetic resonance imaging functional network connectivity between patients with restless legs syndrome and controls
Cho Y, Moon H, Lee Y, Chang H, Ku J, Pearlson G, Lee H. P859: Differences in resting-state functional magnetic resonance imaging functional network connectivity between patients with restless legs syndrome and controls. Clinical Neurophysiology 2014, 125: s272. DOI: 10.1016/s1388-2457(14)50892-9.Peer-Reviewed Original Research
2012
Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases
van Rheenen W, van Blitterswijk M, Huisman M, Vlam L, van Doormaal P, Seelen M, Medic J, Dooijes D, de Visser M, van der Kooi A, Raaphorst J, Schelhaas H, van der Pol W, Veldink J, van den Berg L, Weiner M, Aisen P, Petersen R, Clifford R, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Liu E, Montine T, Gamst A, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Beckett L, Harvey D, Gamst A, Donohue M, Kornak J, Dale A, Bernstein M, Felmlee J, Fox N, Thompson P, Schuff N, Alexander G, DeCarli C, Bandy D, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Cairns N, Taylor-Reinwald L, Shaw L, Lee V, Korecka M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kachaturian Z, Frank R, Snyder P, Kaye J, Dolen S, Quinn J, Schneider L, Pawluczyk S, Spann B, Brewer J, Vanderswag H, Heidebrink J, Lord J, Petersen R, Johnson K, S. Doody R, Villanueva-Meyer J, Chowdhury M, Stern Y, Honig L, Bell K, Morris J, Mintun M, Schneider S, Marson D, Griffith R, Clark D, Grossman H, Mitsis E, Romirowsky A, deToledo-Morrell L, Shah R, Duara R, Varon D, Roberts P, Albert M, Onyike C, Kielb S, Rusinek H, de Leon M, Glodzik L, Doraiswamy P, Petrella J, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Lopez O, Oakley M, Simpson D, Ismail M, Brand C, Mulnard R, Thai G, Mc-Adams-Ortiz C, Diaz-Arrastia R, Martin-Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Bartzokis G, Silverman D, Lu P, Apostolova L, Graff-Radford N, Parfitt F, Johnson H, Farlow M, Herring S, Hake A, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Wu C, Johnson N, Mesulam M, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Frey M, Johnson K, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Killiany R, Norbash A, Obisesan T, Wolday S, Bwayo S, Lerner A, Hudson L, Ogrocki P, DeCarli C, Fletcher E, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Hendin B, Scharre D, Kataki M, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Saykin A, Santulli R, Schwartz E, Williamson J, Sink K, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Longmire C, Spicer K, Kwon S, Kim J, Cho K, Shin D, Ko Y, Lee S, Cha J, Kim Y, Shin D, Jang H, Choi N, Hong S, Rha J, Hong K, Kim E, Choi J, Sohn S, Shin W, HyukHeo S, Chung K, Park J, Lee J, Park J, Park T, Bae H, Han M, Kwon H, Lee K, Lee T, Jeong D, Lee J, Ashwal S, deVeber G, Ferriero D, Fullerton H, Ichord R, Kirkham F, Lynch J, O'Callaghan F, Pavlakis S, Sebire G, Willan A, Willan A, Sofronas M, Dlamini N, Elbers J, Nowak-Göttl U, Düring C, Krümpel A, Plumb P, Journeycake J, van de Bruinhorst K, Gossett D, Hernandez Chavez M, Monagle P, MacKay M, Barnes C, Furmedge J, Gordon A, Benedict S, Bale J, Nielson D, Abdalla A, Chadehumbe M, Kabbouche M, Karti P, Phillips T, Friedman N, Rizkallah E, Zamel K, Wiznitzer M, Lidsky K, Bernard T, Goldenberg N, Armstrong-Wells J, Booth F, Nash M, Beslow L, Carpenter J, Chang T, Weinstein S, Kan L, Smith R, Maytal J, Sy-Kho R, Yager J, Massicotte P, Ashwal S, McClure C, Bjornson B, Hukin J, Bucevska M, Kent S, Riviello J, Rivkin M, Trenor C, Amlie-Lefond C, Whelan H, Ferriero D, Fullerton H, Fox C, Pavlakis S, Goodman S, Levinson K, Kolk A, Laugesaar R, Talvik T, Imam H, Thomas T, Golomb M, Kirton A, Heyer G, Ganesan V, Saengpattrachai M, Crosswell H, Mancuso A, Tatishvili N, Yeh A, Humpherys P, Abraham L, Alveal L, Ortiz M, Altuna D, Maxit C, Gonzalez V, Alam M, Buckley D, Penney S, Jordan L, Grabowski E, Chan A, Deray M, Khatib Z, Kovacevic G, Kosofsky B, Leifer D, Nass R, Wong V, Catsman C, El-Hakam L, Sebire G, Cholette J, Narang S, Lerner N, Carpenter S, Bischoff K, Frei-Jones M, Masur D, Epstein L, Bagiella E, Hinton V, Gallentine W, Rende E, Provenzale J, Voyvodic J, Song A, Conklin T, O'Hara K, Seinfeld S, Conry J, Glauser T, Ayala J, Facchini R, Sigalova M, Hannigan J, Weiss E, Mancini A, Curran J, Ahlm S, Renaldi J, Umanzour D, Kim A, Hamidullah A, Litherland C, Bonner M, Xu Y, Van de Water V, Grasso S, Kushner D, Culbert J, Bush B, Chandrasekaran S, Davis L, Rogers C, Sabo C, Wang H, Noebels J. Hexanucleotide repeat expansions in C9ORF72 in the spectrum of motor neuron diseases. Neurology 2012, 79: 878-882. PMID: 22843265, DOI: 10.1212/wnl.0b013e3182661d14.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAmyotrophic Lateral SclerosisC9orf72 ProteinCohort StudiesConfidence IntervalsDementiaDNADNA Repeat ExpansionFemaleFrontotemporal Lobar DegenerationGenotypeHumansMaleMiddle AgedMotor Neuron DiseaseMuscular Atrophy, SpinalMutationParkinson DiseasePolymerase Chain ReactionProportional Hazards ModelsProteinsSurvivalYoung AdultConceptsProgressive muscular atrophyPrimary lateral sclerosisAmyotrophic lateral sclerosisSporadic amyotrophic lateral sclerosisParkinson's diseaseShorter survivalLateral sclerosisRelatives of patientsFamilial aggregationRepeat expansionHexanucleotide repeat expansionControl subjectsMotor neuronsLarge cohortPatientsMuscular atrophyGenetic testingEarly onsetMajor causeDementiaC9orf72SclerosisFALSEarly ageDutch descentD-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report
Norberg M, Gilliam C, Villavicencio A, Pearlson G, Tolin D. D-Cycloserine for Treatment Nonresponders With Obsessive-Compulsive Disorder: A Case Report. Cognitive And Behavioral Practice 2012, 19: 338-345. DOI: 10.1016/j.cbpra.2011.05.002.Peer-Reviewed Original ResearchObsessive-compulsive disorderN-methyl-D-aspartate (NMDA) receptor partial agonist D-cycloserinePartial agonist D-cycloserineThird of patientsD-cycloserineCourse of ERPReuptake inhibitorsCase reportTreatment nonrespondersEffective treatmentPatientsPrior treatmentResponse preventionGreater reductionTreatmentDisordersPresent studyAdequate responseNonrespondersPrevention
2010
Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data
Calhoun V, Wu L, Kiehl K, Eichele T, Pearlson G. Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data. Acta Neuropsychiatrica 2010, 22: 127-138. PMID: 21331320, PMCID: PMC3038634, DOI: 10.1111/j.1601-5215.2010.00467.x.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChronic schizophrenia patientsSchizophrenia patientsJoint independent component analysisHealthy control subjectsFronto-temporal regionsMagnetic resonance imagingLatency abnormalitiesDeviant stimuliControl subjectsHealthy controlsHemodynamic differencesPatientsBipolar disorderAlzheimer's diseaseResonance imagingAuditory oddball stimuliDiseaseSchizophreniaGroup differencesOddball stimuliN2 responseElectrical changesAberrant processingN2 amplitude
2009
Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study
Juárez M, White T, Pearlson G, Bustillo J, Lauriello J, Ho B, Bockholt H, Clark V, Gollub R, Magnotta V, Machado G, Calhoun V. Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study. NeuroImage 2009, 47: s158. DOI: 10.1016/s1053-8119(09)71664-7.Peer-Reviewed Original Research
2007
A Maximal-Correlation Approach Using ICA for Testing Functional Network Connectivity Applied to Schizophrenia
Jafri M, Pearlson G, Calhoun V. A Maximal-Correlation Approach Using ICA for Testing Functional Network Connectivity Applied to Schizophrenia. 2007, 468-471. DOI: 10.1109/isbi.2007.356890.Peer-Reviewed Original Research
2000
MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder
Rabins P, Aylward E, Holroyd S, Pearlson G. MRI findings differentiate between late‐onset schizophrenia and late‐life mood disorder. International Journal Of Geriatric Psychiatry 2000, 15: 954-960. PMID: 11044878, DOI: 10.1002/1099-1166(200010)15:10<954::aid-gps224>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsLate-onset schizophreniaLate-life bipolar disorderBilateral cortical atrophyLarger third ventriclesRight temporal hornLate-life mood disordersLate-life depressionDegree of atrophyNormal control groupGender-matched controlsFunctional imaging studiesSulcal enlargementCortical atrophyMRI findingsTemporal hornFunctional abnormalitiesSylvian fissureMood disordersThird ventricleOutpatient servicesMRI scansPatientsAffective disordersControl groupBipolar disorderRate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease
Aylward E, Codori A, Rosenblatt A, Sherr M, Brandt J, Stine O, Barta P, Pearlson G, Ross C. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disorders 2000, 15: 552-560. PMID: 10830423, DOI: 10.1002/1531-8257(200005)15:3<552::aid-mds1020>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsUseful outcome measureCaudate volumeHuntington's diseaseSymptomatic patientsSymptomatic subjectsCaudate atrophyOutcome measuresLongitudinal changesStages of HDMean interscan intervalSerial magnetic resonance imagesHD gene mutationNeurological examSymptomatic groupModerate symptomsMild symptomsSymptomatic stagePresymptomatic carriersTherapeutic studiesTreatment effectivenessPatientsMagnetic resonance imagesDiseaseGene mutationsInterscan intervalSex Differences in Inferior Parietal Lobule Volume in Schizophrenia
Frederikse M, Lu A, Aylward E, Barta P, Sharma T, Pearlson G. Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia. American Journal Of Psychiatry 2000, 157: 422-427. PMID: 10698819, DOI: 10.1176/appi.ajp.157.3.422.Peer-Reviewed Original ResearchConceptsGray matter volumeLobule volumesFemale subjectsSchizophrenic patientsMatter volumeMale subjectsFemale schizophrenic subjectsSex differencesClinical disease expressionMale schizophrenic patientsAssociation cortical regionsFemale schizophrenic patientsHealthy female subjectsHealthy male subjectsPathophysiology of schizophreniaVolumetric sex differencesInferior parietal lobuleCortical regionsSchizophrenic subjectsParietal lobuleDisease expressionPatientsSchizophreniaSubjectsMagnetic resonance
1999
Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study
Sharma T, Lancaster E, Sigmundsson T, Lewis S, Takei N, Gurling H, Barta P, Pearlson G, Murray R. Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study. Schizophrenia Research 1999, 40: 111-120. PMID: 10593451, DOI: 10.1016/s0920-9964(99)00143-7.Peer-Reviewed Original ResearchConceptsSchizophrenic patientsOccipitoparietal regionsControl subjectsNormal patternCortical regionsLack of asymmetryFamilial schizophrenic patientsNormal cerebral asymmetryHealthy control subjectsFirst-degree relativesObligate carriersCerebral asymmetryRegional brain volumesUnrelated control subjectsDegree relativesRight sensorimotorNormal brain asymmetryBrain volumeMaudsley Family StudyPatientsOccipital asymmetryUnaffected relativesSchizophreniaBrain asymmetryNormal asymmetryStructural and functional brain changes in bipolar disorder: a selective review
Pearlson G. Structural and functional brain changes in bipolar disorder: a selective review. Schizophrenia Research 1999, 39: 133-140. PMID: 10507524, DOI: 10.1016/s0920-9964(99)00112-7.Peer-Reviewed Original Research
1997
Superior temporal gyrus and planum temporale in schizophrenia: A selective review
Pearlson G. Superior temporal gyrus and planum temporale in schizophrenia: A selective review. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1997, 21: 1203-1229. PMID: 9460087, DOI: 10.1016/s0278-5846(97)00159-0.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusPlanum temporaleTemporal gyrusNon-human primate researchPET/fMRIFormal thought disorderFunctional pathologySchizophrenic patientsAuditory hallucinationsTemporolimbic areasNeocortical regionsStructural abnormalitiesBrain regionsNeocortical networksExperience hallucinationsFunctional studiesCortical networksNormal asymmetrySchizophreniaThought disorderPatientsNormal structureVolume reductionGyrusPrimate research