Jorge Sepulcre, MD, PhD
Cards
About
Research
Publications
2024
Reorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsMultimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption
d’Oleire Uquillas F, Sefik E, Li B, Trotter M, Steele K, Seidlitz J, Gesue R, Latif M, Fasulo T, Zhang V, Kislin M, Verpeut J, Cohen J, Sepulcre J, Wang S, Gomez J. Multimodal evidence for cerebellar influence on cortical development in autism: structural growth amidst functional disruption. Molecular Psychiatry 2024, 1-15. PMID: 39390225, DOI: 10.1038/s41380-024-02769-1.Peer-Reviewed Original ResearchAutism spectrum disorderNeurotypical childrenFunctional connectivityMultimodal evidenceFunctional connectivity analysisModel of autismCerebro-cerebellar pathwayAtypical connectivitySpectrum disorderConnectivity analysisEarly adolescenceASD childrenCerebellar influenceBehavioral developmentNeurodevelopmental disordersFunctional-structural relationshipsCerebellar structuresAutismYoung childhoodLiving brainCerebellumFunctional synchronizationThalamusSignificant lateralizationCerebral cortexCortical hubs of highly superior autobiographical memory
Orwig W, Diez I, Bueichekú E, Pedale T, Parente F, Campolongo P, Schacter D, Sepulcre J, Santangelo V. Cortical hubs of highly superior autobiographical memory. Cortex 2024, 179: 14-24. PMID: 39094240, DOI: 10.1016/j.cortex.2024.06.018.Peer-Reviewed Original ResearchConceptsSuperior autobiographical memoryAutobiographical memoryCortical hubsWhole-brain connectivity analysisPattern of increased connectivityResting-state fMRI dataWhole-brain analysisAutobiographical memory networkPosterior cingulate cortexMidline areaSeed-based analysisFunctional brain connectivityGraph theory analysisCingulate cortexNeural underpinningsNeuroimaging studiesEnhance memoryRemembering eventsBrain regionsControl participantsConnectivity analysisFMRI dataBrain connectivityCortical regionsWhole-brainTau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive powerSpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patternsMulti-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Communications Medicine 2024, 4: 65. PMID: 38580832, PMCID: PMC10997795, DOI: 10.1038/s43856-024-00497-9.Peer-Reviewed Original ResearchMemory declineMedial anterior prefrontal cortexAging brainWhole-brain voxel-wiseAnterior prefrontal cortexRegion-of-interest analysisResting-state functional MRIObjective memory declineOccipito-parietal regionsMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksPrefrontal cortexMnemonic anosognosiaTau burdenBiomarkers of AD pathologyMode networkParieto-occipital areasFunctional network connectivity disruptionFunctional MRIBrain phenotypesVoxel-wiseBehavioral conditionsBehavioral biomarkersA late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study
Beucke J, Diez I, Sepulcre J, Mundorf A, Kaufmann C, Orr S, Pitman R, Shin L. A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study. Journal Of Psychiatric Research 2024, 171: 230-237. PMID: 38316103, PMCID: PMC11113072, DOI: 10.1016/j.jpsychires.2024.01.032.Peer-Reviewed Original ResearchConceptsAmygdalar responsesCombat exposureCombat stressSymptoms of post-traumatic stress disorderPost-traumatic stress disorderTermination of stress exposureCombat-exposed veteransDiscordant twin studiesImpact brain functionAmygdalar functionStress disorderStress exposureAcute stressTwin studiesTwin pairsCombat experienceNeurogenetic mechanismsBrain functionEarly adulthoodEffects of ageConfounding effects of ageTwin siblingsVeteransPsychosocial evidenceGene expression
2023
Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain
Bueichekú E, Diez I, Gagliardi G, Kim C, Mimmack K, Sepulcre J, Vannini P. Multi‐modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080294.Peer-Reviewed Original ResearchMnemonic anosognosiaOccipito-parietal regionsMemory declineBrain phenotypesSelf-referential brain networkObjective memory testsObjective memory declineResting-state fMRIPosterior cerebral cortexMulti-modal neuroimagingNetwork connectivity patternsAlzheimer's diseaseFunctional connectivity networksGraph theory metricsTau burdenNeurocognitive profileBiomarkers of AD pathologyMemory testMemory impairmentBetween-group comparisonsFunctional network connectivity disruptionBrain networksAging brainAnosognosiaBehavioral conditionsSpatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition
Bueichekú E, Diez I, Kim C, Becker A, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079747.Peer-Reviewed Original ResearchLC integrityLocus coeruleusLower cognitive performanceLongitudinal tau accumulationCognitive performanceEmergence of cognitive declineAssociated with lower cognitive performanceTemporal cortex areasIn vivo neuroimaging dataTau accumulationTau progressionCortical tau depositionAlzheimer's diseaseNeuroimaging studiesMTL structuresNeuroimaging dataAD-related pathologyCognitive declineCortex areaPartial correlationMisfolded tau proteinContext of ADGLM analysisSites of tauLipid biosynthetic processRelationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity
Cacciamani F, Gagliardi G, Mimmack K, Qiao K, Bueichekú E, Marshall G, Sepulcre J, Diez I, Vannini P. Relationship between loss of awareness of cognitive decline and tau pathology in the Alzheimer’s disease spectrum: modulatory role of resting‐state functional connectivity. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079806.Peer-Reviewed Original ResearchAwareness of cognitive declineResting-state functional connectivityLinear regression modelsSelf-referential networkHigher tau burdenFunctional connectivityCognitive declineRegression modelsTau accumulationAlzheimer's diseaseImpaired resting-state functional connectivityAlzheimer's disease spectrumResting-state fMRI dataAssociated with tau accumulationDorsal attention networkReduced awarenessWithin-network connectivityModulatory roleLow awarenessTau burdenEffects of tauCognitive function indicesTau interactionsSalience networkTau pathology