Shannon Whirledge, PhD, MSc
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Associate Professor, Obstetrics, Gynecology & Reproductive Sciences; Assistant Professor, Environmental Health Sciences
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Appointments
Titles
Associate Professor, Obstetrics, Gynecology & Reproductive Sciences; Assistant Professor, Environmental Health Sciences
Contact Info
Appointments
Titles
Associate Professor, Obstetrics, Gynecology & Reproductive Sciences; Assistant Professor, Environmental Health Sciences
Contact Info
About
Titles
Associate Professor Term
Associate Professor, Obstetrics, Gynecology & Reproductive Sciences; Assistant Professor, Environmental Health SciencesBiography
Dr. Shannon Whirledge received her B.S. in Biology and B.A. in Political Science in 2003 from Winthrop University and was awarded her Ph.D. in Molecular and Cellular Biology in 2009 from Baylor College of Medicine. She continued her studies in reproductive endocrinology as an NIH IRTA fellow at the NIEHS. During her postdoctoral fellowship, Dr. Whirledge received her Masters in Health Science in Clinical Research from Duke University. In 2016, she joined the faculty of the Department of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine.
Dr. Whirledge is an active member of the Endocrine Society, Women in Endocrinology, the Society for the Study of Reproduction, and the Society for Reproductive Investigation. Dr. Whirledge has served as an editorial board member for Endocrinology and serves as an ad hoc reviewer for other journals within the fields of Cell Biology and Reproductive Sciences.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Associate Professor on TermPrimary
Other Departments & Organizations
- Discovery to Cure Internship
- Obstetrics, Gynecology & Reproductive Sciences
- Reproductive Sciences
Education & Training
- MSc
- Duke University, Master of Health Science in Clinical Research (2016)
- IRTA Postdoctoral Fellow
- NIH-NIEHS (2016)
- PhD
- Baylor College of Medicine, Molecular and Cellular Biology (2009)
Research
Overview
Medical Subject Headings (MeSH)
Endocrine Disruptors; Endocrinology; Infertility, Female; Leiomyoma; Molecular Biology; Pregnancy Complications; Reproductive Medicine; Uterus
ORCID
0000-0002-5435-4141
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shannon Whirledge's published research.
Publications Timeline
A big-picture view of Shannon Whirledge's research output by year.
Research Interests
Research topics Shannon Whirledge is interested in exploring.
Clare Flannery, MD
Mancy Tong, PhD
Vikki M Abrahams, PhD
26Publications
864Citations
Uterus
Infertility, Female
Leiomyoma
Publications
2023
Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα
Tong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEndometrial stromal cellsInflammatory responseStromal cellsHuman endometrial stromal cellsToll-like receptor signalingSex hormone levelsMenstrual cycle stageToll-like receptorsImmune response changesViral double-stranded RNAHuman EnSCsEndometrial responseProinflammatory cytokinesSuccessful pregnancyMenstrual cycleHuman endometriumHormone levelsMajor cell typesImmune responseNFκB p65Viral infectionDecidualizationBacterial lipopolysaccharideReceptor signalingBacterial components
2021
LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH
Glenn T, Silva E, Suarez P, Flannery C, Whirledge S. LOCAL ACTIVATION OF GLUCOCORTICOID SIGNALING IN UTERINE FIBROID CELLS DRIVES GROWTH. Fertility And Sterility 2021, 116: e419-e420. DOI: 10.1016/j.fertnstert.2021.07.1121.Peer-Reviewed Original ResearchCombinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus
Oakley R, Whirledge S, Petrillo M, Riddick N, Xu X, Moy S, Cidlowski J. Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus. Neurobiology Of Stress 2021, 15: 100369. PMID: 34368410, PMCID: PMC8326231, DOI: 10.1016/j.ynstr.2021.100369.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDentate gyrus neuronsMineralocorticoid receptorGyrus neuronsKnockout miceSingle knockout counterpartsConditioned fear testDouble knockout miceStress hormone receptorsPrimary stress hormoneCA2 neuronsHippocampal glucocorticoidRelated nuclear receptorsKnockout counterpartsNeuronal deathDentate gyrusNeuronal markersLarge cohortMouse hippocampusPsychiatric disordersGlucocorticoidsHippocampusCell proliferation pathwaysChronic stressStress hormonesProfound neurodegenerationObesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice
Huang J, Xiao E, Tal A, Kelly K, Kim J, Whirledge S, Flannery C. Obesity Induces Elevated Oxidative Stress in Uteri of Reproductive Age Mice. Journal Of The Endocrine Society 2021, 5: a752-a752. DOI: 10.1210/jendso/bvab048.1529.Peer-Reviewed Original ResearchCitationsConceptsWeeks of dietNC miceHF miceHigher body fatProtein carbonylsOxidative stressAge miceBody fatChronic diet-induced obesityDiet-induced obese miceObesity-related disruptionIndependent risk factorInsulin tolerance testingHigh-fat chowLong-term obesitySeverity of obesityC57BL/6 female miceDiet-induced obesityHigh fat consumptionUterine oxidative stressCYP enzymatic activitiesAge-dependent increaseElevated oxidative stressDNA damageCytochrome P450 expressionChapter 9 Mechanism of glucocorticoid action in immunology—Basic concepts
Wood M, Whirledge S. Chapter 9 Mechanism of glucocorticoid action in immunology—Basic concepts. 2021, 147-170. DOI: 10.1016/b978-0-12-818508-7.00020-8.Peer-Reviewed Original ResearchCitationsConceptsGlucocorticoid receptorEpigenetic modificationsPosttranslational modificationsTranscription factorsDNA bindingTissue-specific immune responsesOverall physiologyCell typesGlucocorticoid-mediated effectsNuclear receptorsImmune cell typesFundamental processesReceptor isoformsLevels of hormonesRelative expressionReceptor actionReproductive systemChapter 9 MechanismsGlucocorticoid bioavailabilityAutoimmune diseasesGlucocorticoid actionImmune responseFetal developmentCo-FactorImmune system
2019
SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation
Smalls B, Millard C, Kisanga E, Flannery C, Al-Hendy A, Whirledge S. SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation. Journal Of The Endocrine Society 2019, 3: sun-019. PMCID: PMC6553416, DOI: 10.1210/js.2019-sun-019.Peer-Reviewed Original ResearchCitationsConceptsSelective progesterone receptor modulatorsAnti-glucocorticoid activityUlipristal acetateGlucocorticoid receptorEffect of UPAHuman uterine fibroid tissueLong-term therapeutic agentGR antagonist RU-486Progesterone receptor modulatorsAntagonist RU 486Post-marketing analysisGlucocorticoid-induced expressionLower glucocorticoid receptorUterine fibroid tissueEndogenous glucocorticoid receptorSynthetic glucocorticoid dexamethasoneCell linesUterine fibroid cellsHuman uterine fibroid cellsFemale reproductive systemUtLM cellsHepatic failureLiver injuryPR expressionTherapeutic optionsSAT-005 Gene Expression and Behavioral Alterations in Mice with Conditional Knockout of GR, MR, or Both GR and MR in the Hippocampus
Oakley R, Whirledge S, Riddick N, Quinn M, Xu X, Moy S, Cidlowski J. SAT-005 Gene Expression and Behavioral Alterations in Mice with Conditional Knockout of GR, MR, or Both GR and MR in the Hippocampus. Journal Of The Endocrine Society 2019, 3: sat-005. PMCID: PMC6552087, DOI: 10.1210/js.2019-sat-005.Peer-Reviewed Original ResearchConceptsMineralocorticoid receptorDouble knockout miceGlucocorticoid receptorGRKO miceKnockout miceEmx1-Cre miceRelated mineralocorticoid receptorDepression-like behaviorHippocampal glucocorticoid receptorsConditioned fear testOpen field testMonths of agePrimary stress hormoneSwim testPsychiatric disordersUnique signaling pathwaysBehavioral alterationsBody weightCognitive impairmentHippocampusGlucocorticoidsMutant miceStress hormonesBrain functionMiceIn Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines
Kisanga E, Tang Z, Guller S, Whirledge S. In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines. Journal Of Visualized Experiments 2019 DOI: 10.3791/58942-v.Peer-Reviewed Original ResearchCitationsChapter 5 Steroid Hormone Action
Whirledge S, Cidlowski J. Chapter 5 Steroid Hormone Action. 2019, 115-131.e4. DOI: 10.1016/b978-0-323-47912-7.00005-6.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSteroid hormone receptorsSteroid hormonesHormone receptorsSteroid hormone actionComplex molecular eventsGroup of hormonesContext-specific mannerPhysiologic responsesNongenomic actionsHormone actionHormoneSignal transductionTranscription factorsReceptorsPhysiologic processesIntracellular proteinsReproductive systemMolecular eventsChemical messengers
2017
Stress and Implantation Failure
Deaton J, Patel B, Johnston-MacAnanny E, Yu J, Whirledge S, Wilson A, David Wininger J, Shu Y, Taylor R, Berga S. Stress and Implantation Failure. 2017, 103-124. DOI: 10.1007/978-3-319-71967-2_7.Peer-Reviewed Original ResearchConceptsImplantation failureHCG productionSecretion of estradiolHPO axisMenstrual bleedingOvarian axisEndometrial developmentMetabolic factorsElevated glucocorticoidsEndometriumInappropriate exposureEndocrine signalsLaboratory stressorPutative mechanismsQuantitative exposureImplantationFemale reproductionEstradiolOvulationHealthy blastocystAlterationsFailureExposureBleedingObesity
Academic Achievements and Community Involvement
activity Member
Public ServiceYale Pathways-Reproductive Physiology ClubDetails06/02/2017 - PresentDescriptionOutreach program for local high school students to discover the science of reproduction.activity Liaison
CommitteesStatus of Women in MedicineDetails12/15/2016 - PresentDescriptionLiaison for the Department of Obstetrics, Gynecology, and Reproductive Sciencesactivity Board Member
Professional OrganizationsEndocrine SocietyDetails04/01/2016 - 03/31/2019DescriptionSelected member of the Basic Science Focus Groupactivity Editorial Board
Peer Review Groups and Grant Study SectionsEndocrinologyDetails04/01/2016 - 03/31/2019DescriptionEditorial Board Memberhonor Eugenia Rosemberg Abstract Award
International AwardEndocrine SocietyDetails03/23/2019United States
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Locations
Laboratory for Surgery, Obsterics & Gynecology
Academic Office
375 Congress Avenue, Rm 204C
New Haven, CT 06519