Na Liu, PhD
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2024
Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study
Yang T, Hou Z, Zhang Q, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Zou Y, Wan C, Li Y. Personalized embryo transfer guided by rsERT with hourly precision improves pregnancy outcomes in patients with a receptive window of implantation: a pilot study. Journal Of Assisted Reproduction And Genetics 2024, 41: 2657-2665. PMID: 39254797, PMCID: PMC11534956, DOI: 10.1007/s10815-024-03246-y.Peer-Reviewed Original ResearchIntrauterine pregnancy ratePersonalized embryo transferWindow of implantationEmbryo transferPropensity score matchingImplantation rateET groupCenter for Reproductive MedicineResultsBefore propensity score matchingImplant failure rateGroup compared to controlsRetrospective pilot studyConventional embryo transferMultiple-pregnancy ratesEndometrial receptivity testCentral South UniversityPregnancy outcomesTransferred embryosPilot studyPregnancy ratePatientsSouth UniversityReproductive medicineScore matchingConfounding factors
2023
A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella
Chang T, Tang H, Zhou X, He J, Liu N, Li Y, Xiang W, Yao Z. A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella. Reproductive BioMedicine Online 2023, 48: 103765. PMID: 38492416, DOI: 10.1016/j.rbmo.2023.103765.Peer-Reviewed Original ResearchConceptsHomozygous nonsense variantMultiple morphological abnormalitiesWhole-exome sequencingSperm flagellaAssociated with multiple morphological abnormalitiesMitochondrial function of spermatozoaFlagella-associated proteinsFunction of spermatozoaPotential gene variantsMitochondrial metabolic dysfunctionSperm ultrastructureFlagellar assemblyPatient's spermatozoaFlagellar defectsRate of apoptosisConcentration of reactive oxygen speciesMale infertilitySanger sequencingReactive oxygen speciesMitochondrial functionSpermSpermatozoaMutated genesFunctional associationDisease phenotypeAn endometrium of type C along with an endometrial thickness of < 8 mm are risk factors for ectopic pregnancy after stimulated cycles with fresh embryo transfer
Zhao Y, Xu A, Liu D, Liu N, Li Y, Yao Z, Tian F, Tang H, Li Y. An endometrium of type C along with an endometrial thickness of < 8 mm are risk factors for ectopic pregnancy after stimulated cycles with fresh embryo transfer. BMC Pregnancy And Childbirth 2023, 23: 713. PMID: 37803277, PMCID: PMC10557322, DOI: 10.1186/s12884-023-05920-y.Peer-Reviewed Original ResearchConceptsFresh embryo transferRisk of ectopic pregnancyEctopic pregnancyEndometrial thicknessEmbryo transferEndometrial thickness < 8 mmStimulated cyclesRisk factorsGnRH antagonist protocolDose of gonadotropinsControlled ovarian hyperstimulationRisk factors of ectopic pregnancyOdds ratioAntagonist protocolOvarian hyperstimulationPeri-transplantation periodLogistic regression analysisIntrauterine pregnancyEndometrial featuresGnRH agonistPregnancyLarger dosesEarly diagnosisEndometriumPregnancy cyclePretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth?
Xu B, Hou Z, Liu N, Zhao J, Li Y. Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth? Journal Of Ovarian Research 2023, 16: 197. PMID: 37743479, PMCID: PMC10518919, DOI: 10.1186/s13048-023-01277-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferFrozen-thawed embryo transfer cyclesHormone replacement treatmentLive birth rateLong-acting GnRH agonistPolycystic ovary syndromeFET groupEndometrial preparationGnRHa groupFET cyclesClinical pregnancyGnRH agonistPrimary infertilityLive birthsFollicular phaseIncreased chance of clinical pregnancyIrregular menstruationDay of progesterone administrationGonadotropin-releasing hormone agonistBirth rateChance of clinical pregnancyEmbryo transfer cyclesLong-acting GnRHaDay of menstruationSubgroups of ageCan biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study
He A, Wu H, Zou Y, Wan C, Zhao J, Zhang Q, Liu N, Liu D, Li Y, Fu J, Li H, Huang X, Yang T, Hu C, Hou Z, Sun Y, Dong X, Wu J, Lu S, Li Y. Can biomarkers identified from the uterine fluid transcriptome be used to establish a noninvasive endometrial receptivity prediction tool? A proof-of-concept study. Reproductive Biology And Endocrinology 2023, 21: 20. PMID: 36805767, PMCID: PMC9938621, DOI: 10.1186/s12958-023-01070-0.Peer-Reviewed Original ResearchConceptsIn vitro fertilization patientsIn vitro fertilizationEndometrial receptivityFrozen-thawed blastocyst transferCell-cell adherens junctionsTranscriptomic biomarkersSequencing data qualityTranscriptome sequencing dataEndometrial receptivity testIntrauterine pregnancyBlastocyst transferPregnancy outcomesEndometrial biopsyFluid specimensSequence dataER-associatedEmbryo implantationRNA-seqClinical application potentialReceptive endometriumSmall cohortPregnancyAdherens junctionsHub genesPatients
2022
Homeostatic Model Assessment for Insulin Resistance Is Associated With Late Miscarriage in Non-Dyslipidemic Women Undergoing Fresh IVF/ICSI Embryo Transfer
Yang T, Yang Y, Zhang Q, Liu D, Liu N, Li Y, Yao Z, Zhang Y, Tian F, Zhao J, Li Y. Homeostatic Model Assessment for Insulin Resistance Is Associated With Late Miscarriage in Non-Dyslipidemic Women Undergoing Fresh IVF/ICSI Embryo Transfer. Frontiers In Endocrinology 2022, 13: 880518. PMID: 35784578, PMCID: PMC9247267, DOI: 10.3389/fendo.2022.880518.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeAssisted reproductive technologyMiscarriage rateIVF/ICSI-ETAssociated with late miscarriageInfertile womenFertilization/intracytoplasmic sperm injection-embryo transferIVF/ICSI-embryo transferPolycystic ovary syndrome groupNon-PCOS groupNon-PCOS populationHOMA-IR groupReproductive Medicine CenterLate miscarriagePCOS womenHOMA-IRHomeostatic model assessmentIncreased HOMA-IRReproductive technologyCentral South UniversityEmbryo transferPercentage of macrosomiaInsulin resistanceSubgroup analysisModel assessmentAn Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles
Zhao Y, Liu D, Liu N, Li Y, Yao Z, Tian F, Xu A, Li Y. An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles. Frontiers In Endocrinology 2022, 13: 884553. PMID: 35813636, PMCID: PMC9261458, DOI: 10.3389/fendo.2022.884553.Peer-Reviewed Original ResearchConceptsFreeze-thaw embryo transferEctopic pregnancyEndometrial thicknessEmbryo transferEndometrial thickness < 8 mmRisk factors of ectopic pregnancyRisk of ectopic pregnancyRisk factorsIncreased risk of EPPregnancy cycleRisk of EPPeri-transplantation periodLogistic regression analysisAbnormal endometrial receptivityEndometrial typeUnivariate analysisEndometrial receptivityPrevent EPPregnancyPrimary outcomeIncreased riskEarly diagnosisRegression analysisRiskPeristaltic waves