Kathleen Cardinale, MD
Assistant ProfessorCards
About
Research
Publications
2018
Immunotherapy in selected patients with Down syndrome disintegrative disorder
Cardinale KM, Bocharnikov A, Hart SJ, Baker JA, Eckstein C, Jasien JM, Gallentine W, Worley G, Kishnani PS, Van Mater H. Immunotherapy in selected patients with Down syndrome disintegrative disorder. Developmental Medicine & Child Neurology 2018, 61: 847-851. PMID: 30548468, DOI: 10.1111/dmcn.14127.Peer-Reviewed Original ResearchConceptsCognitive declineDisintegrative disorderDown syndromeHistory of autoimmunitySmall case seriesAutoimmune thyroid diseaseSymptoms of catatoniaAdditional immunotherapyIntravenous immunoglobulinCase seriesMedical recordsThyroid diseaseImmunotherapyPAPER ADDSPatientsCatatoniaInsomniaCore symptomsPsychosisAutistic featuresYoung adultsSymptomsAutoimmunityDisordersSyndromeAn Update on the Treatment of Pediatric Autoimmune Encephalitis
Stingl C, Cardinale K, Van Mater H. An Update on the Treatment of Pediatric Autoimmune Encephalitis. Current Treatment Options In Rheumatology 2018, 4: 14-28. PMID: 29780690, PMCID: PMC5957495, DOI: 10.1007/s40674-018-0089-z.Peer-Reviewed Original ResearchSecond-line therapyRefractory diseaseNeuropsychiatric deficitsProspective randomized placebo-controlled trialInterleukin-6 inhibitor tocilizumabLow-dose IL-2Randomized placebo-controlled trialPediatric autoimmune encephalitisPlacebo-controlled trialEarly treatment initiationFirst-line therapyFirst-line treatmentSecond-line agentsIL-6 blockadeMajority of patientsProteasome inhibitorsRecent FindingsTo dateAutoimmune encephalitisTreatment escalationIntravenous immunoglobulinMycophenolate mofetilClinical improvementPharmacologic treatmentPrompt treatmentTreatment initiation
2012
Acetylcholinesterase inhibition ameliorates deficits in motivational drive
Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK. Acetylcholinesterase inhibition ameliorates deficits in motivational drive. Behavioral And Brain Functions 2012, 8: 15. PMID: 22433906, PMCID: PMC3328273, DOI: 10.1186/1744-9081-8-15.Peer-Reviewed Original ResearchMeSH KeywordsAnhedoniaAnimalsAnxietyBehavior, AnimalBody WeightCholinesterase InhibitorsChronic DiseaseDriveHabituation, PsychophysiologicHindlimb SuspensionImage Processing, Computer-AssistedImmunohistochemistryMaleMiceMice, Inbred C57BLMotivationNervous SystemPhenotypePhysostigmineProto-Oncogene Proteins c-fosQuinineRestraint, PhysicalStress, PsychologicalSwimmingTasteConceptsChronic restraint stress protocolRestraint stress protocolCholinergic basal forebrain systemApathetic behaviorRecent clinical trialsBasal forebrain systemNeuronal activity patternsNumerous neurological disordersFosB immunohistochemistryClinical trialsCholinergic systemMedial septumNucleus accumbensCRS protocolImmediate early gene activationForebrain systemNeurological disordersNeuropsychiatric disordersMotivational driveStress protocolEarly gene activationAnticholinesteraseAcetylcholinesterase inhibitionDeficitsRemediation of deficits
Academic Achievements & Community Involvement
Clinical Care
Overview
A pediatric neurologist, Kathleen Cardinale, MD, makes it a point to always talk to her patients first—even if the younger ones maybe don’t understand what kind of doctor she is.
“I might tell them I take care of their brain, or their head, and leave it at that,” says Dr. Cardinale, who has an interest in treating children with developmental disabilities, including autism, cerebral palsy and spina bifida. “While it may be tempting to talk to the adults in the room, I always explain things to the child first.”
Dr. Cardinale says neurology is a natural fit for her. “I’ve known for a long time that I would do something with neuroscience. It’s fascinating to think about how we develop our personalities and how we think,” she says. “And I realized during my medical training how much I love kids and what joy they bring me, so it was easy to put the two together.”
Working with children and families who are struggling with a neurologic disability fulfilling, Dr. Cardinale says. “I love being there for a family. For example, a child with cerebral palsy may be in a wheelchair or need help feeding or have a multitude of other challenges,” she says. “That can be overwhelming and they need someone advocating for them. I enjoy supporting them, problem-solving and helping them connect with other specialists.”
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