2007
The road to modularity
Wagner GP, Pavlicev M, Cheverud JM. The road to modularity. Nature Reviews Genetics 2007, 8: 921-931. PMID: 18007649, DOI: 10.1038/nrg2267.Peer-Reviewed Original ResearchConceptsProtein-protein interaction networkMolecular systems biologyPatterns of evolutionGene duplicationGene regulationEvolutionary biologyNeutral mutationsBiological organizationQuantitative traitsInteraction networksSystems biologyStructure of macromoleculesEnvironmental conditionsBiologyDuplicationTraitsMutationsRegulationSelectionModularityMacromolecules
2001
The tetrapod limb: A hypothesis on its origin
Wagner G, Chiu C. The tetrapod limb: A hypothesis on its origin. Journal Of Experimental Zoology 2001, 291: 226-240. PMID: 11598912, DOI: 10.1002/jez.1100.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTetrapod limbsExpression domainsHoxa-13Hoxa-11Fin-limb transitionExclusive expression domainsMajor morphological adaptationsProximal-distal axisVertebrate evolutionFin developmentHoxa-11 expressionTerrestrial lifestyleFin skeletonMorphological adaptationsDevelopmental mechanismsExpression patternsLimb budPaleontological evidenceGenetic hypothesisExpressionZebrafishEvolutionHomologyAquaticGenes