2002
Evolution of functionally conserved enhancers can be accelerated in large populations: a populationgenetic model
Carter A, Wagner G. Evolution of functionally conserved enhancers can be accelerated in large populations: a populationgenetic model. Proceedings Of The Royal Society B 2002, 269: 953-960. PMID: 12028779, PMCID: PMC1690979, DOI: 10.1098/rspb.2002.1968.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConserved SequenceEnhancer Elements, GeneticEvolution, MolecularGenetics, PopulationMathematical ComputingModels, GeneticConceptsPopulation sizeRelated Drosophila speciesCis-regulatory elementsPopulation genetic modelsRate of evolutionModerate population sizesDrosophila speciesDrosophila EnhancerVertebrate enhancersDynamics of fixationDifferent taxaCompensatory mutationsNeutral rateGeneration timeSmall populationEnhancerTaxaSpatial organizationLarge populationSpeciesMutationsSequenceVertebratesEvolutionPopulation
2000
Evolution of Hoxa-11 in Lineages Phylogenetically Positioned along the Fin–Limb Transition
Chiu C, Nonaka D, Xue L, Amemiya C, Wagner G. Evolution of Hoxa-11 in Lineages Phylogenetically Positioned along the Fin–Limb Transition. Molecular Phylogenetics And Evolution 2000, 17: 305-316. PMID: 11083943, DOI: 10.1006/mpev.2000.0837.Peer-Reviewed Original ResearchMeSH KeywordsAlanineAmino Acid SequenceAnimalsBinding SitesCell LineConserved SequenceDNAEvolution, MolecularExtremitiesFishesHeLa CellsHomeodomain ProteinsHumansIntronsMolecular Sequence DataPhylogenyProtein IsoformsSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidXenopusXenopus ProteinsZebrafishZebrafish ProteinsConceptsFin-limb transitionSequence evolutionAmino acid sequence comparisonsHoxa-11Domain IElectrophoretic mobility shift assaysMobility shift assaysAmino acid sequencePatterns of evolutionConsecutive alanine residuesWhole cell extractsEvolutionary timeAppendage developmentCharacter reconstructionEvolutionary changeTranscription factorsSequence comparisonIntron sequencesNucleotide conservationShift assaysAcid sequenceAlanine residuesLineagesAccelerated rateCoelacanthHox cluster genomics in the horn shark, Heterodontus francisci
Kim C, Amemiya C, Bailey W, Kawasaki K, Mezey J, Miller W, Minoshima S, Shimizu N, Wagner G, Ruddle F. Hox cluster genomics in the horn shark, Heterodontus francisci. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 1655-1660. PMID: 10677514, PMCID: PMC26491, DOI: 10.1073/pnas.030539697.Peer-Reviewed Original ResearchConceptsHox gene clustersHox clustersHOXA clusterGene clusterHeterodontus francisciVertebrate body planHorn sharkGene-coding sequencesDivergence timesEvolutionary historyBody planHoxD clusterEvolutionary significanceSequence motifsVertebrate phylogenyDevelopmental processesGenetic entitiesStructural similarityControl motifsSharksCluster organizationMotifPhylogenyGenomicsNoncoding