2009
Frame‐shifts of digit identity in bird evolution and Cyclopamine‐treated wings
Vargas AO, Wagner GP. Frame‐shifts of digit identity in bird evolution and Cyclopamine‐treated wings. Evolution & Development 2009, 11: 163-169. PMID: 19245548, DOI: 10.1111/j.1525-142x.2009.00317.x.Peer-Reviewed Original Research
2008
Pleiotropic scaling of gene effects and the ‘cost of complexity’
Wagner GP, Kenney-Hunt JP, Pavlicev M, Peck JR, Waxman D, Cheverud JM. Pleiotropic scaling of gene effects and the ‘cost of complexity’. Nature 2008, 452: 470-472. PMID: 18368117, DOI: 10.1038/nature06756.Peer-Reviewed Original ResearchConceptsQuantitative trait lociEffects of pleiotropyOrganismal complexityGenetic sequence dataHigher organismsEvolutionary biologyTrait lociMouse genomeSequence dataBiology questionsSkeletal traitsGene effectsMost mutationsCost of complexityGenetic mutationsTraitsMutationsMultiple effectsGenomeSkeletal characteristicsPleiotropyLociPleiotropicOrganismsBiology
2001
What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible
Wagner G. What is the promise of developmental evolution? Part II: A causal explanation of evolutionary innovations may be impossible. Journal Of Experimental Zoology 2001, 291: 305-309. PMID: 11754010, DOI: 10.1002/jez.1130.Commentaries, Editorials and LettersThe Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change
STADLER B, STADLER P, WAGNER G, FONTANA W. The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change. Journal Of Theoretical Biology 2001, 213: 241-274. PMID: 11894994, DOI: 10.1006/jtbi.2001.2423.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapNeo-Darwinian modelGenotype-phenotype modelsPhenotypic innovationPhenotypic evolutionGenetic accessibilityEvolutionary trajectoriesEvolutionary changeNatural selectionPhenotypic charactersPhenotype spaceGenotype spaceRNA sequencesSecondary structureFitness landscapePossible phenotypesFitness considerationsRNA modelCharacter autonomyPhenotypeRecent computational workFoldingEvolutionRegionSequenceThe Test Distribution of Modularity Statistics: A Correction and a Clarification
Housworth E, Mezey J, Cheverud J, Wagner G. The Test Distribution of Modularity Statistics: A Correction and a Clarification. Genetics 2001, 158: 1381-1381. PMID: 11478289, PMCID: PMC1461726, DOI: 10.1093/genetics/158.3.1381.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsModeling Genetic Architecture: A Multilinear Theory of Gene Interaction
Hansen T, Wagner G. Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction. Theoretical Population Biology 2001, 59: 61-86. PMID: 11243929, DOI: 10.1006/tpbi.2000.1508.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapGene interactionsQuantitative genetic variationEffects of epistasisGenetic canalizationGenetic experimentsGenetic variationGene substitutionGenetic backgroundEpistasisTractable modelComplex functionsCentral importanceLociBiologyCanalizationPhenotypeGenotypesInteractionSum of linear
2000
Is the Genotype-Phenotype Map Modular?: A Statistical Approach Using Mouse Quantitative Trait Loci Data
Mezey J, Cheverud J, Wagner G. Is the Genotype-Phenotype Map Modular?: A Statistical Approach Using Mouse Quantitative Trait Loci Data. Genetics 2000, 156: 305-311. PMID: 10978294, PMCID: PMC1461239, DOI: 10.1093/genetics/156.1.305.Peer-Reviewed Original ResearchModeling the Evolution of Genetic Architecture: A Continuum of Alleles Model with Pairwise A×A Epistasis
WAGNER G, MEZEY J. Modeling the Evolution of Genetic Architecture: A Continuum of Alleles Model with Pairwise A×A Epistasis. Journal Of Theoretical Biology 2000, 203: 163-175. PMID: 10704300, DOI: 10.1006/jtbi.2000.1074.Peer-Reviewed Original Research
1999
Is Hsp90 a regulator of evolvability?
Wagner G, Chiu C, Hansen T. Is Hsp90 a regulator of evolvability? Journal Of Experimental Zoology 1999, 285: 116-118. PMID: 10440722, DOI: 10.1002/(sici)1097-010x(19990815)285:2<116::aid-jez3>3.0.co;2-p.Commentaries, Editorials and Letters
1998
Genetic measurement theory of epistatic effects
Wagner G, Laubichler M, Bagheri-Chaichian H. Genetic measurement theory of epistatic effects. Genetica 1998, 102-103: 569-580. PMID: 9766965, DOI: 10.1023/a:1017088321094.Peer-Reviewed Original ResearchConceptsEpistatic effectsGenotype-phenotype mapMendelian genetic systemMathematical population geneticsAverage additive effectPairs of lociGenetic architecturePopulation geneticsEvolutionary changeEvolutionary phenomenaGenetic systemGenotypic varianceMetabolic fluxSecond locusEpistasisGene substitutionMutation effectsAdditive effectAdult body weightGene effectsSecond mutationLocus BLociMutationsNegative interactions