2002
Evolution of functionally conserved enhancers can be accelerated in large populations: a populationgenetic model
Carter A, Wagner G. Evolution of functionally conserved enhancers can be accelerated in large populations: a populationgenetic model. Proceedings Of The Royal Society B 2002, 269: 953-960. PMID: 12028779, PMCID: PMC1690979, DOI: 10.1098/rspb.2002.1968.Peer-Reviewed Original ResearchConceptsPopulation sizeRelated Drosophila speciesCis-regulatory elementsPopulation genetic modelsRate of evolutionModerate population sizesDrosophila speciesDrosophila EnhancerVertebrate enhancersDynamics of fixationDifferent taxaCompensatory mutationsNeutral rateGeneration timeSmall populationEnhancerTaxaSpatial organizationLarge populationSpeciesMutationsSequenceVertebratesEvolutionPopulation
2001
The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change
STADLER B, STADLER P, WAGNER G, FONTANA W. The Topology of the Possible: Formal Spaces Underlying Patterns of Evolutionary Change. Journal Of Theoretical Biology 2001, 213: 241-274. PMID: 11894994, DOI: 10.1006/jtbi.2001.2423.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapNeo-Darwinian modelGenotype-phenotype modelsPhenotypic innovationPhenotypic evolutionGenetic accessibilityEvolutionary trajectoriesEvolutionary changeNatural selectionPhenotypic charactersPhenotype spaceGenotype spaceRNA sequencesSecondary structureFitness landscapePossible phenotypesFitness considerationsRNA modelCharacter autonomyPhenotypeRecent computational workFoldingEvolutionRegionSequence
1996
Evidence for Four Hox Clusters in the KillifishFundulus heteroclitus(Teleostei)
Misof B, Wagner G. Evidence for Four Hox Clusters in the KillifishFundulus heteroclitus(Teleostei). Molecular Phylogenetics And Evolution 1996, 5: 309-322. PMID: 8728389, DOI: 10.1006/mpev.1996.0026.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBiological EvolutionDNA PrimersFishesGenes, HomeoboxHomeodomain ProteinsHumansKillifishesKineticsMiceModels, GeneticMolecular Sequence DataMultigene FamilyPhylogenyPolymerase Chain ReactionProbabilitySequence Homology, Amino AcidSequence Homology, Nucleic AcidConceptsHox clustersMammalian Hox genesTeleost Fundulus heteroclitusDiploid teleostsHox genesHomeobox sequencesPCR surveySequence comparisonLower vertebratesFundulus heteroclitusCognate groupsFirst evidenceSequenceOrthologsCluster AVertebratesTeleostsGenesNumber of representativesHeteroclitusClustersHumansMiceFragmentsRepresentativesPCR‐survey of hox‐genes of the zebrafish: New sequence information and evolutionary implications
Misof B, Blanco M, Wagner G. PCR‐survey of hox‐genes of the zebrafish: New sequence information and evolutionary implications. Journal Of Experimental Zoology 1996, 274: 193-206. PMID: 8882497, DOI: 10.1002/(sici)1097-010x(19960215)274:3<193::aid-jez6>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsHox gene complementGene complementPCR surveyHox gene sequencesZebrafish Danio rerioNumber of genesNew sequence informationInsufficient sequence variationZebrafish genesHox genesPutative genesEvolutionary implicationsBony fishDanio rerioHuman genomeGene sequencesSequence variationSequence informationCognate groupsGenesType sequenceSequenceGenomeRerioFragments