Epistasis and the Mutation Load: A Measurement-Theoretical Approach
Hansen T, Wagner G. Epistasis and the Mutation Load: A Measurement-Theoretical Approach. Genetics 2001, 158: 477-485. PMID: 11333254, PMCID: PMC1461645, DOI: 10.1093/genetics/158.1.477.Peer-Reviewed Original ResearchConceptsMutation-selection equilibriumGene interactionsEpistatic interactionsMutation loadStrength of epistasisMutation-selection balanceGenomic mutation rateHigher-order gene interactionsSynergistic epistasisMean fitnessOptimal genotypeEpistatic effectsTwofold disadvantageEpistasisMutation rateGenetic backgroundSynergistic interactionSystematic relationshipGenesLociInteraction intensityInteractionFitnessInteraction densityGenotypesModeling Genetic Architecture: A Multilinear Theory of Gene Interaction
Hansen T, Wagner G. Modeling Genetic Architecture: A Multilinear Theory of Gene Interaction. Theoretical Population Biology 2001, 59: 61-86. PMID: 11243929, DOI: 10.1006/tpbi.2000.1508.Peer-Reviewed Original ResearchConceptsGenotype-phenotype mapGene interactionsQuantitative genetic variationEffects of epistasisGenetic canalizationGenetic experimentsGenetic variationGene substitutionGenetic backgroundEpistasisTractable modelComplex functionsCentral importanceLociBiologyCanalizationPhenotypeGenotypesInteractionSum of linear