1996
Ion Coupling Stoichiometry for the Norepinephrine Transporter in Membrane Vesicles from Stably Transfected Cells (∗)
Gu H, Wall S, Rudnick G. Ion Coupling Stoichiometry for the Norepinephrine Transporter in Membrane Vesicles from Stably Transfected Cells (∗). Journal Of Biological Chemistry 1996, 271: 6911-6916. PMID: 8636118, DOI: 10.1074/jbc.271.12.6911.Peer-Reviewed Original ResearchConceptsMembrane vesiclesTransmembrane ion gradientsLLC-PK1 cellsMajor substrateTransport substratesTransfected CellsStably Transfected CellsIon gradientsCoupling stoichiometryNet positive chargeDA accumulationVesiclesSubstrate moleculesTransportersNorepinephrine transporterAccumulationCellsGamma-aminobutyric acidCotransportDAGradientStoichiometrySubstrateAbsenceTransport processes
1992
Platelet serotonin transporter
Rudnick G, Humphreys C. Platelet serotonin transporter. Methods In Enzymology 1992, 215: 213-224. PMID: 1435323, DOI: 10.1016/0076-6879(92)15065-k.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAdenosine TriphosphateAnimalsBiological TransportBlood PlateletsCarrier ProteinsCell FractionationCell MembraneCell SeparationCentrifugationHumansImipramineIndicators and ReagentsMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsRadioligand AssaySerotoninSerotonin Plasma Membrane Transport ProteinsSwineTritium
1988
Antidepressant binding to the porcine and human platelet serotonin transporters.
Humphreys C, Levin J, Rudnick G. Antidepressant binding to the porcine and human platelet serotonin transporters. Molecular Pharmacology 1988, 33: 657-63. PMID: 3380080.Peer-Reviewed Original Research
1984
The hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases.
Dean G, Fishkes H, Nelson P, Rudnick G. The hydrogen ion-pumping adenosine triphosphatase of platelet dense granule membrane. Differences from F1F0- and phosphoenzyme-type ATPases. Journal Of Biological Chemistry 1984, 259: 9569-9574. PMID: 6204985, DOI: 10.1016/s0021-9258(17)42738-4.Peer-Reviewed Original ResearchConceptsGranule ATPaseGranule membranesMitochondrial membraneATP hydrolysisIon-translocating ATPasesEnergy-transducing membranesDense granule membraneIdentical assay conditionsF1F0-ATPasesSubstrate specificityPlasma membraneMitochondrial ATPaseInhibitor sensitivityATPasesATPaseATPase activityConcentrations of NaN3Cation requirementATPase moleculesMembraneN-ethylmaleimideAssay conditionsAdenosine triphosphataseEfrapeptinOligomycin
1983
The serotonin transporter-imipramine "receptor".
Talvenheimo J, Fishkes H, Nelson P, Rudnick G. The serotonin transporter-imipramine "receptor". Journal Of Biological Chemistry 1983, 258: 6115-6119. PMID: 6853478, DOI: 10.1016/s0021-9258(18)32380-9.Peer-Reviewed Original Research
1982
The role of chloride ion in platelet serotonin transport.
Nelson P, Rudnick G. The role of chloride ion in platelet serotonin transport. Journal Of Biological Chemistry 1982, 257: 6151-6155. PMID: 7076668, DOI: 10.1016/s0021-9258(20)65119-5.Peer-Reviewed Original ResearchCoupling of transmembrane proton gradients to platelet serotonin transport.
Keyes S, Rudnick G. Coupling of transmembrane proton gradients to platelet serotonin transport. Journal Of Biological Chemistry 1982, 257: 1172-1176. PMID: 7056713, DOI: 10.1016/s0021-9258(19)68170-6.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesSerotonin transportTransmembrane proton gradientPlatelet plasma membraneTransmembrane ion gradientsApparent competitionPlasma membraneMembrane vesiclesProton gradientIon gradientsSerotonin accumulationSole driving forceVesiclesAccumulationSerotonin transporterPH differencePhysiological pHTransportersTransportPH stimulationMembraneGradient
1981
Anion-dependent sodium ion conductance of platelet plasma membranes.
Nelson P, Rudnick G. Anion-dependent sodium ion conductance of platelet plasma membranes. Biochemistry 1981, 20: 4246-9. PMID: 6269584, DOI: 10.1021/bi00518a002.Peer-Reviewed Original ResearchInhibition of platelet serotonin transport by propranolol.
Rudnick G, Bencuya R, Nelson P, Zito R. Inhibition of platelet serotonin transport by propranolol. Molecular Pharmacology 1981, 20: 118-23. PMID: 7290078.Peer-Reviewed Original Research
1980
Solubilization of the platelet plasma membrane serotonin transporter in an active form.
Talvenheimo J, Rudnick G. Solubilization of the platelet plasma membrane serotonin transporter in an active form. Journal Of Biological Chemistry 1980, 255: 8606-8611. PMID: 7410380, DOI: 10.1016/s0021-9258(18)43541-7.Peer-Reviewed Original ResearchEvidence for two distinct serotonin transport systems in platelets.
Rudnick G, Fishkes H, Nelson P, Schuldiner S. Evidence for two distinct serotonin transport systems in platelets. Journal Of Biological Chemistry 1980, 255: 3638-3641. PMID: 7364762, DOI: 10.1016/s0021-9258(19)85751-4.Peer-Reviewed Original Research
1979
Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport.
Talvenheimo J, Nelson P, Rudnick G. Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. Journal Of Biological Chemistry 1979, 254: 4631-4635. PMID: 438209, DOI: 10.1016/s0021-9258(17)30057-1.Peer-Reviewed Original Research
1978
Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium.
Rudnick G, Nelson P. Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium. Biochemistry 1978, 17: 4739-42. PMID: 728383, DOI: 10.1021/bi00615a021.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesLipophilic cation triphenylmethylphosphoniumMembrane potentialMembrane vesiclesElectroneutral mechanismVesicle membraneIon effluxPorcine blood plateletsAbsence of valinomycinAddition of valinomycinPotassium gradientBlood plateletsValinomycinElectrogenic mechanismMembraneNet influxMechanismDinitrophenolVesiclesTransportLittle effectInfluxTriphenylmethylphosphoniumAbsenceEfflux