2010
Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue*
Tavoulari S, Rizwan AN, Forrest LR, Rudnick G. Reconstructing a Chloride-binding Site in a Bacterial Neurotransmitter Transporter Homologue*. Journal Of Biological Chemistry 2010, 286: 2834-2842. PMID: 21115480, PMCID: PMC3024779, DOI: 10.1074/jbc.m110.186064.Peer-Reviewed Original ResearchConceptsChloride-binding siteConformational changesAdjacent binding sitesSingle point mutationProkaryotic homologuesSubstrate translocationIon-binding sitesTransporter homologueTransport proteinsNeurotransmitter transportersNeurotransmitter transportPoint mutationsBinding sitesHomologuesProteinMutationsCl(-) bindsDirect evidenceTherapeutic drugsSitesDependent formTranslocationTransportersBindsResidues
2002
Chemical Modification Strategies for Structure‐Function Studies
Rudnick G. Chemical Modification Strategies for Structure‐Function Studies. 2002, 125-141. DOI: 10.1002/0471434043.ch8.ChaptersTransmembrane domainConformational changesPolytopic membrane proteinsStructure-function studiesMembrane proteinsTransporter proteinsReactive residuesLipid bilayersProteinTransportersExternal faceExternal loopChemical modification strategiesDomainChemical modificationSubstrateCysteineResiduesSitesMembraneModificationBilayers