2003
Psychotic Depression and Mortality
Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC. Psychotic Depression and Mortality. American Journal Of Psychiatry 2003, 160: 574-576. PMID: 12611843, DOI: 10.1176/appi.ajp.160.3.574.Peer-Reviewed Original ResearchConceptsPsychotic depressionNonpsychotic major depressionHigh mortality rateMortality rateMajor depressionHospital admissionNonpsychotic depressionVital statusMedical statusCumulative Illness Rating ScaleIllness Rating ScaleMajor depressive disorderProportional hazards modelSeverity of depressionPsychotic major depressionPositive DST resultsSurvival analytic techniquesElevated mortality ratesDepressive disorderDST resultsHazards modelPatientsGreater riskRating ScaleDepression
2001
Antidepressant-associated mania and psychosis resulting in psychiatric admissions.
Preda A, MacLean RW, Mazure CM, Bowers MB. Antidepressant-associated mania and psychosis resulting in psychiatric admissions. The Journal Of Clinical Psychiatry 2001, 62: 30-3. PMID: 11235925, DOI: 10.4088/jcp.v62n0107.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGeneral hospital psychiatric unitAntidepressant-associated maniaNewer atypical agentsSide effect profileSerotonin reuptake inhibitorsHospital psychiatric unitRate of admissionAdverse behavioral effectsAntidepressant useReuptake inhibitorsEffect profileAtypical agentsPsychiatric admissionsAntidepressant drugsPsychiatric unitBehavioral effectsAdverse behavioral reactionsAdmissionSignificant increasePsychosisManiaDrugsTolerabilityAntidepressants
1994
Characteristics of desipramine-refractory depression.
Nelson JC, Mazure CM, Jatlow PI. Characteristics of desipramine-refractory depression. The Journal Of Clinical Psychiatry 1994, 55: 12-9. PMID: 8294386.Peer-Reviewed Original ResearchConceptsDepressive episodePoor responseMajor depressionNonpsychotic unipolar major depressionPrior treatment failureAdequate blood levelsWeeks of hospitalizationDrug responseUnipolar major depressionRecurrence of depressionDefinite personality disorderDiagnosis of melancholiaConsecutive inpatientsDesipramine levelsTreatment failureBlood levelsGeneral HospitalInitial severityPlasma concentrationsDrug treatmentSecondary depressionDepression InventoryPatientsPersonality disorderDepression
1991
A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting
1990
Value of the DST for predicting response of patients with major depression to hospitalization and desipramine
Nelson JC, Mazure CM, Jatlow PI. Value of the DST for predicting response of patients with major depression to hospitalization and desipramine. American Journal Of Psychiatry 1990, 147: 1488-1492. PMID: 2221161, DOI: 10.1176/ajp.147.11.1488.Peer-Reviewed Original ResearchConceptsDexamethasone suppression testResponse of patientsMajor depressionNegative dexamethasone suppression testPositive dexamethasone suppression testWeeks of hospitalizationNonpsychotic major depressionPlasma levelsSuppression testRate of responseAntidepressant drugsDrug treatmentPatientsHospitalizationDesipraminePrior reportsDepressionResponsePrior studiesPlaceboFindingsTrialsWeeksThe relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects.
Mazure CM, Nelson JC, Jatlow PI, Kincare P, Bowers MB. The relationship between blood perphenazine levels, early resolution of psychotic symptoms, and side effects. The Journal Of Clinical Psychiatry 1990, 51: 330-4. PMID: 2199431.Peer-Reviewed Original ResearchMeSH KeywordsAdultAkathisia, Drug-InducedBasal Ganglia DiseasesBenztropineClinical Trials as TopicDose-Response Relationship, DrugDrug Administration ScheduleFemaleHospitalizationHumansMaleParkinson Disease, SecondaryPerphenazinePsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsExtrapyramidal side effectsSide effectsBrief Psychiatric Rating Scale (BPRS) totalSerious extrapyramidal side effectsIndividual BPRS itemsResolution of psychosisEarly resolutionBlood level monitoringBlood levelsIndividual symptomsTherapeutic thresholdPsychotic symptomsPsychotic inpatientsScale totalDrug efficacyBPRS itemsPerphenazine concentrationSymptomsPsychosisPerphenazineLevel monitoringPredictors of hospital outcome without antidepressants in major depression
Mazure C, Nelson J, Jatlow P. Predictors of hospital outcome without antidepressants in major depression. Psychiatry Research 1990, 33: 51-58. PMID: 2217658, DOI: 10.1016/0165-1781(90)90148-x.Peer-Reviewed Original ResearchConceptsWeeks of hospitalizationHospital outcomesMajor depressionNonpsychotic unipolar major depressionPersonality disorderHamilton Rating ScaleDSM-III melancholiaUnipolar major depressionConsecutive inpatientsAdmission severityHRSD scoresIndependent associationPanic disorderRating ScaleHospital responseDoes melancholia predict response in major depression?
Nelson J, Mazure C, Jatlow P. Does melancholia predict response in major depression? Journal Of Affective Disorders 1990, 18: 157-165. PMID: 2139060, DOI: 10.1016/0165-0327(90)90032-4.Peer-Reviewed Original Research
1989
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS. The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability. JAMA Psychiatry 1989, 46: 1006-1011. PMID: 2684084, DOI: 10.1001/archpsyc.1989.01810110048007.Peer-Reviewed Original Research