2019
SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model
Miletta M, Shanabrough M, Sestan-Pesa M, Varela L, Mancini G, Spadaro O, Zeiss C, Dixit V, Dietrich M, Horvath T. SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model. Journal Of The Endocrine Society 2019, 3: sun-097. PMCID: PMC6553392, DOI: 10.1210/js.2019-sun-097.Peer-Reviewed Original ResearchNormal food intakeAgRP neuronsAnorexia nervosaFood intakeFood restrictionActivity-based anorexia (ABA) paradigmWeight lossPostnatal day 36Ad libitumPostnatal day 7Week old micePostnatal day 3Diphtheria toxinHigh mortality rateFed ad libitumAnorexia modelDTR miceHours animalsAd libitum foodNeuronal lossProtein (AgRP) neuronsArcuate nucleusNew neural circuitsPsychiatric illnessOld mice
2015
Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats
Toth I, Kiss DS, Jocsak G, Somogyi V, Toronyi E, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. PLOS ONE 2015, 10: e0137462. PMID: 26339901, PMCID: PMC4560379, DOI: 10.1371/journal.pone.0137462.Peer-Reviewed Original ResearchConceptsAd libitum fed animalsFemale ratsRight-sided dominanceSatiety stateFed animalsOvariectomized female ratsContribution of estrogenMetabolic differencesHours of fastingIntensity of cellsState 3 mitochondrial respirationHypothalamic functionMetabolic asymmetryTissue metabolismHypothalamusEstrogenProportion of animalsHypothalamic asymmetryRatsAd libitumLateralizationHigher centersMitochondrial respiration rateEnergy metabolism