2024
Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch
Wheeler L, Kremen V, Mersereau C, Ornelas G, Yadav T, Cormier D, Derry A, Lopez A, McQuown K, Sladky V, Benjamin C, Giacino J, Worrell G, Blumenfeld H, Team S. Automatic responsiveness testing in epilepsy with wearable technology: The ARTiE Watch. Epilepsia 2024 PMID: 39559901, DOI: 10.1111/epi.18181.Peer-Reviewed Original ResearchCloud infrastructureElectrographic seizuresSmartphone softwareMobile platformWearable technologySmartwatchTest sequencesMonitor unit settingsVideo-electroencephalographic monitoringLong-term video-electroencephalographic monitoringEpilepsy monitoring unitMayo ClinicDiagnostic evaluationDecreased responseUnit settingSeizuresBehavioral responsesPlatformAssessment of behavioral responsesMonitor unitsEpilepsyResponse phenotypesWatchResponse testEvaluation of behavioral responses
2023
Highlights From the Annual Meeting of the American Epilepsy Society 2022
Valencia I, Alexander A, Andrade D, Arevalo-Astrada M, Rubiños C, Auer N, Bainbridge J, Baxendale S, Bartolomei F, Becker D, Berg A, Bernasconi A, Bernasconi N, Bernhardt B, Bhatnagar S, Blümcke I, Blumenfeld H, Buchanan G, Burdette D, Burneo J, Busch R, Chauvel P, Chin J, Clifford L, Conner K, Cook M, Conway J, Diaz-Arastia R, Drees C, French J, Ganguly T, Gelfand M, Glauser T, Gleichgerrcht E, Goldman A, Gonzalez-Martinez J, Gotman J, Grinspan Z, Guilfoyle S, Gupta G, Hammer M, Hartman A, Hentges K, Hogan R, Huh L, Hyslop A, Jobst B, Josephson C, Kelley S, Knupp K, Koepp M, Kothare S, Krook-Magnuson E, Kwasa J, La Vega-Talbott M, Lam A, Lee J, Lowenstein D, Maturu S, Mayor L, McDonald C, McKee H, McKhann G, Meador K, Mefford H, Michael E, Mikati M, Millichap J, Mitchell J, Myers L, Naritoku D, Neville K, Noebels J, O’Brien T, Oluigbo C, Patel A, Pavlova M, T. Paz J, Pennell P, Perry M, Perucca P, Pitkänen A, Plueger M, Pugh M, Quigg M, Reddy S, Ryan C, Reynolds T, Sajatovic M, Santana-Gomez C, Schommer L, Schuele S, Shellhaas R, Shrey D, Singh R, Sperling M, Suleman S, Templer J, Thom M, Trinka E, Varadkar S, Velez-Ruiz N, Velíšková J, Voskobiynyk Y, Wagner J, Wagnon J, Waller C, Waller J, Wang Z, Welborn M, Wirrell E, Jobst B. Highlights From the Annual Meeting of the American Epilepsy Society 2022. Epilepsy Currents 2023 DOI: 10.1177/15357597231187227.Peer-Reviewed Original ResearchAnti-seizure medicationsPathophysiology of epilepsyPost-traumatic epilepsyTraumatic brain injuryDifferent disease statesMechanism of actionPrepandemic timesNumber of physiciansBrain injuryEpilepsy careSeizure generationEpilepsy comorbiditiesEpilepsyReproductive healthHealth professionalsPatient advocatesVirtual offeringSatellite symposiumDisease statesBasic science lecturesReimbursement policiesGroup sessionsSmall group sessionsSessionsSkills workshops
2022
Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing
Ramirez V, Litvinov B, Gunawardane NA, Zhao CW, Yotter C, Quraishi IH, Blumenfeld H. Evaluating consciousness and awareness during focal seizures: responsiveness testing versus recall testing. Epileptic Disorders 2022, 24: 899-905. PMID: 35904040, PMCID: PMC10042123, DOI: 10.1684/epd.2022.1472.Peer-Reviewed Original ResearchConceptsFocal seizuresResponsiveness testingCurrent International LeagueClinical practice settingEEG-video monitoringEpilepsy monitoring unitImportant clinical settingsEpilepsy guidelinesPatient groupFocal epilepsyIctal eventsClinical careInternational LeagueSeizuresPatientsClinical settingPractice settingsClassification guidelinesFurther studiesEpilepsyResponsivenessRecall of experiencesPreliminary findingsRecall testingSettingA machine‐learning approach for predicting impaired consciousness in absence epilepsy
Springer M, Khalaf A, Vincent P, Ryu JH, Abukhadra Y, Beniczky S, Glauser T, Krestel H, Blumenfeld H. A machine‐learning approach for predicting impaired consciousness in absence epilepsy. Annals Of Clinical And Translational Neurology 2022, 9: 1538-1550. PMID: 36114696, PMCID: PMC9539371, DOI: 10.1002/acn3.51647.Peer-Reviewed Original Research
2019
Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study
Cohen E, Antwi P, Banz BC, Vincent P, Saha R, Arencibia CA, Ryu JH, Atac E, Saleem N, Tomatsu S, Swift K, Hu C, Krestel H, Farooque P, Levy S, Wu J, Crowley M, Vaca FE, Blumenfeld H. Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study. Epilepsia 2019, 61: 19-28. PMID: 31646628, PMCID: PMC7424790, DOI: 10.1111/epi.16356.Peer-Reviewed Original ResearchConceptsEpileptiform dischargesGeneralized epileptiform dischargesEEG amplitudeClinical seizuresElectroencephalographic featuresGeneralized epilepsyLarger sample sizeDriving impairmentClinical accompanimentBaseline testingPilot studyMotor vehicle safetyLonger durationSimultaneous EEGSeizuresVisual stimuliEEGSubjectsStimuliRiskSafetyDurationSample sizeResponseEpilepsy
2017
Functional MRI in Basic Epilepsy Research☆
Englot D, Blumenfeld H. Functional MRI in Basic Epilepsy Research☆. 2017 DOI: 10.1016/b978-0-12-809324-5.00092-4.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesPathophysiologyAnestheticsMRI
2016
Chapter 16 Epilepsy and Consciousness
Blumenfeld H. Chapter 16 Epilepsy and Consciousness. 2016, 255-270. DOI: 10.1016/b978-0-12-800948-2.00016-9.Peer-Reviewed Original ResearchSeizure typesImpaired consciousnessNormal consciousnessDiverse seizure typesTemporal lobe seizuresTonic-clonic seizuresParietal association cortexMedial thalamusUpper brainstemAbsence seizuresNeuronal activityPatient injuryBehavioral testingAssociation cortexEpileptic seizuresSeizuresInterhemispheric regionSynchronous dischargesLateral frontalNeuroimaging signalsAbnormal increaseAnatomical regionsEpilepsySpecific anatomical structuresConsciousness system
2013
Temporal Lobe Seizures
Furman M, Blumenfeld H. Temporal Lobe Seizures. 2013, 51-62. DOI: 10.1007/978-3-642-37580-4_4.Peer-Reviewed Original ResearchTemporal lobe seizuresTemporal epilepsyTemporal lobeFocal temporal lobe seizuresNetwork inhibition hypothesisSlow electroencephalogram activityLoss of consciousnessParietal association cortexImpaired consciousnessCortical dysfunctionSide effectsAnimal modelsNovel treatmentsAssociation cortexDeep anesthesiaAwake stateHuman patientsElectrophysiological techniquesMemory lossSeizuresElectroencephalogram (EEG) activityElectrophysiological dataEpilepsyCortexLobe
2012
Impaired consciousness in epilepsy
Blumenfeld H. Impaired consciousness in epilepsy. The Lancet Neurology 2012, 11: 814-826. PMID: 22898735, PMCID: PMC3732214, DOI: 10.1016/s1474-4422(12)70188-6.Peer-Reviewed Original ResearchConceptsConsciousness systemQuality of lifeImpaired consciousnessEmotional healthDiverse seizure typesNormal human lifeComplex partial seizuresImpairment of consciousnessImproved treatment strategiesBehavioral testingBrain dysfunctionPartial seizuresSeizure typesTreatment strategiesEpileptic seizuresConsciousnessEpilepsySeizuresHuge consequencesNeuroimagingAlertnessAnatomical structuresSame setImpairmentLife
2009
IMAGING | SPECT in Epilepsy Research
Purcaro M, Blumenfeld H. IMAGING | SPECT in Epilepsy Research. 2009, 558-564. DOI: 10.1016/b978-012373961-2.00024-2.Peer-Reviewed Original ResearchEpilepsy researchUseful imaging modalityInterictal SPECT imagesSingle photon emissionIctal dystoniaExtratemporal epilepsyPresurgical localizationHypothalamic hamartomaSurgical interventionInfantile spasmsSurgical successEpileptogenic focusPostsurgical outcomesSeizure localizationNeurological disordersEpilepsyImaging modalitiesMillions of peoplePhoton emissionSPECT imagesSPECTMedicationsSpasmDystoniaHamartomaIMAGING | Functional MRI in Basic Epilepsy Research
Englot D, Blumenfeld H. IMAGING | Functional MRI in Basic Epilepsy Research. 2009, 539-544. DOI: 10.1016/b978-012373961-2.00023-0.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingInvasive electrophysiological techniquesPathophysiology of seizuresMagnetic resonance imagingWidespread brain networksUse of anestheticsBasic epilepsy researchConvulsive seizuresAnimal fMRI studiesSeizure onsetResonance imagingElectrophysiological techniquesFunctional MRIEpilepsy researchBrain functionSeizuresFMRI studyBrain networksEpilepsyFMRI investigationSignal changesImagingPathophysiologyAnestheticsMRI