2012
ATP Utilization and RNA Conformational Rearrangement by DEAD-Box Proteins
Henn A, Bradley MJ, De La Cruz EM. ATP Utilization and RNA Conformational Rearrangement by DEAD-Box Proteins. Annual Review Of Biophysics 2012, 41: 247-267. PMID: 22404686, PMCID: PMC7761782, DOI: 10.1146/annurev-biophys-050511-102243.Peer-Reviewed Original ResearchConceptsDEAD-box proteinsNucleotide-dependent interactionRegulatory partner proteinsMolecular motor proteinsMolecular motor functionPartner proteinsRNA helicasesHelicase coreRNA helicaseRNA metabolismVivo foldingATP bindingDBP functionMotor proteinsCellular RNARNA structureQuantitative mechanistic understandingConformational rearrangementsBiophysical investigationsEnzymatic adaptationLarge familyMechanistic understandingProteinRNAAuxiliary domain
2010
A Myosin V Inhibitor Based on Privileged Chemical Scaffolds
Islam K, Chin HF, Olivares AO, Saunders LP, De La Cruz EM, Kapoor TM. A Myosin V Inhibitor Based on Privileged Chemical Scaffolds. Angewandte Chemie International Edition 2010, 49: 8484-8488. PMID: 20878825, PMCID: PMC3063097, DOI: 10.1002/anie.201004026.Peer-Reviewed Original Research
2009
Watching the walk: Observing chemo‐mechanical coupling in a processive myosin motor
De La Cruz EM, Olivares AO. Watching the walk: Observing chemo‐mechanical coupling in a processive myosin motor. All Life 2009, 3: 67-70. PMID: 19794813, PMCID: PMC2707789, DOI: 10.2976/1.3095425.Peer-Reviewed Original ResearchMolecular motorsMolecular motor proteinsNucleotide bindingCell divisionCellular nanomachinesGene transcriptionGenome replicationOrganelle transportMotor proteinsSingle-molecule enzymologyActin filamentsProcessive myosin motorsProtein synthesisMyosin motorsFundamental processesProduct releaseExciting advancesRecent studiesCytoskeletonTranscriptionEnzymologyOrganismsProteinFundamental importanceChemical catalysis
2008
Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology
Krendel M, De La Cruz E. Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology. Protein Reviews 2008, 65-82. DOI: 10.1007/978-0-387-71749-4_5.Peer-Reviewed Original ResearchFundamental cellular processesForm of ATPHydrolysis of ATPActin cytoskeletonProtein functionCellular processesMyosin familyMotor proteinsActin filamentsActin monomersATP moleculesCell membraneDistinct mechanismsPathogenic bacteriaGenerate movementDisease pathologyATPFilamentsForce generationMotilityCytoskeletonOrganellesChemical energyProteinActin
2004
Relating biochemistry and function in the myosin superfamily
De La Cruz EM, Ostap EM. Relating biochemistry and function in the myosin superfamily. Current Opinion In Cell Biology 2004, 16: 61-67. PMID: 15037306, DOI: 10.1016/j.ceb.2003.11.011.Peer-Reviewed Original Research