2018
Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder
Husky MM, Mazure CM, Kovess-Masfety V. Gender differences in psychiatric and medical comorbidity with post-traumatic stress disorder. Comprehensive Psychiatry 2018, 84: 75-81. PMID: 29723769, DOI: 10.1016/j.comppsych.2018.04.007.Peer-Reviewed Original ResearchConceptsSevere post-traumatic stress disorderPost-traumatic stress disorderMedical conditionsPsychiatric disordersComposite International Diagnostic Interview Short FormStress disorderComorbid psychiatric disordersCross-sectional general population surveySubstance use disordersGender-specific differencesGeneral population surveyMedical comorbiditiesMedical morbiditySevere headacheComorbid depressionSocietal burdenGeneral populationSevere casesUse disordersGreater oddsGender differencesNeck problemsPTSD diagnosisPTSD sufferersAnxiety disorders
2017
Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey‐Smith S, Fowler C, Ellis K, Martins RN, Salvado O, Doré V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Pietrzak RH, Maruff P, Imaging B. Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study. International Journal Of Geriatric Psychiatry 2017, 33: 405-413. PMID: 28736899, PMCID: PMC5773367, DOI: 10.1002/gps.4761.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesAlzheimer DiseaseAnxiety DisordersApolipoprotein E4AttentionBrain-Derived Neurotrophic FactorCognitionDepressive DisorderDisease ProgressionExecutive FunctionFemaleHumansLogistic ModelsMaleMiddle AgedPositron-Emission TomographyProspective StudiesQuality of LifeRisk FactorsSex FactorsConceptsOlder adultsAnxiety symptomsPredominant trajectoriesRisk factorsLatent growth mixture modelingAlzheimer's diseaseApolipoprotein epsilon 4 alleleSex-specific risk factorsLower attentional functionBinary logistic regression analysisEpsilon 4 alleleElevated depressive symptomsGrowth mixture modelingLogistic regression analysisQuality of lifePositron emission tomographyNormal older adultsSubthreshold depressiveMale sexBaseline predictorsDepressive symptomsVal66Met alleleClinical depressionLower executive functionAnxiety trajectories
2012
Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990–2010
Weinberger AH, Mazure CM, Morlett A, McKee SA. Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990–2010. Nicotine & Tobacco Research 2012, 15: 1014-1031. PMID: 23100459, PMCID: PMC3693502, DOI: 10.1093/ntr/nts213.Peer-Reviewed Original ResearchConceptsRelationship of depressionSmoking cessation outcomesCessation outcomesSmoking cessationTreatment outcomesCurrent major depressive disorderMajor depressive disorderCurrent depression symptomsClinical trialsDepressive disorderMinor depressionMajor depressionInclusion criteriaMEDLINE searchPast diagnosisTreatment approachesDepression symptomsHealth-related risksMajority of studiesPotential articlesDepressionRacial differencesOutcomesCessationSmokers
2010
Inclusion of Women and Gender-Specific Analyses in Randomized Clinical Trials of Treatments for Depression
Weinberger AH, McKee SA, Mazure CM. Inclusion of Women and Gender-Specific Analyses in Randomized Clinical Trials of Treatments for Depression. Journal Of Women's Health 2010, 19: 1727-1732. PMID: 20799923, PMCID: PMC2936499, DOI: 10.1089/jwh.2009.1784.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressionDepressive DisorderFemaleHumansMalePatient SelectionRandomized Controlled Trials as TopicSex FactorsConceptsRecent randomized clinical trialsRandomized clinical trialsClinical trialsGender-specific analysisDepression treatmentHealth (NIH) Revitalization ActCost of depressionInterventional studyInclusion of womenHigh prevalenceTreatment responseMEDLINE searchTreatment efficacyGender differencesPossible gender differencesDepression researchTrialsWomenDepressionNational InstituteRevitalization ActTreatmentFemale participantsOutcomesGender
2008
Relationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence
Weinberger AH, Krishnan-Sarin S, Mazure CM, McKee SA. Relationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence. Addictive Behaviors 2008, 33: 960-963. PMID: 18384974, PMCID: PMC2442160, DOI: 10.1016/j.addbeh.2008.02.013.Peer-Reviewed Original ResearchConceptsShort-term smoking abstinenceShort-term abstinenceSelf-reported experiencesExperienced withdrawal symptomsWithdrawal symptomsBehavioral interventionsSmoking cessationContingency managementCravingRisk beliefsSmoking abstinenceDaily smokersHigh levelsRelationship of riskRisk perceptionNicotine dependenceAbstinenceParticipantsCurrent studySymptoms of withdrawalDepressionBaseline smokingRisk groupsSymptomsRelationship
2004
Childhood maltreatment as a risk factor for adult cardiovascular disease and depression.
Batten SV, Aslan M, Maciejewski PK, Mazure CM. Childhood maltreatment as a risk factor for adult cardiovascular disease and depression. The Journal Of Clinical Psychiatry 2004, 65: 249-54. PMID: 15003081, DOI: 10.4088/jcp.v65n0217.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseRisk factorsChildhood maltreatmentAdult depressionMultiple logistic regression modelAdult cardiovascular diseasePotent risk factorEffective clinical assessmentNational Comorbidity SurveySignificant increaseU.S. National Comorbidity SurveyLogistic regression modelsSex differencesCardiovascular eventsRepresentative sampleClinical assessmentLifetime depressionDiseaseAdult HealthPhysical outcomesWomenDepressionChildhood abuseMenDemographic factorsCombining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
Nelson JC, Mazure CM, Jatlow PI, Bowers MB, Price LH. Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study. Biological Psychiatry 2004, 55: 296-300. PMID: 14744472, DOI: 10.1016/j.biopsych.2003.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAdultAntidepressive Agents, Second-GenerationAntidepressive Agents, TricyclicChromatography, High Pressure LiquidDepressive DisorderDesipramineDouble-Blind MethodDrug Therapy, CombinationFemaleFluoxetineHumansMaleMiddle AgedNorepinephrinePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsSerotoninTreatment OutcomeConceptsMontgomery-Asberg Depression Rating ScaleHamilton Depression Rating Scale scoresDepression Rating Scale scoresNonpsychotic unipolar major depressionPatient withdrew consentTreatment-resistant patientsWeeks of hospitalizationWeeks of treatmentCombination of fluoxetineOnset of actionAdequate plasma levelsDouble-blind conditionsDepression Rating ScaleTreatment of depressionRating Scale scoresUnipolar major depressionDrug plasma concentrationsDMI doseWithdrew consentAntidepressant medicationRandomized studyReuptake inhibitionSerotonergic agentsPlasma levelsMajor depression
2003
Psychotic Depression and Mortality
Vythilingam M, Chen J, Bremner JD, Mazure CM, Maciejewski PK, Nelson JC. Psychotic Depression and Mortality. American Journal Of Psychiatry 2003, 160: 574-576. PMID: 12611843, DOI: 10.1176/appi.ajp.160.3.574.Peer-Reviewed Original ResearchConceptsPsychotic depressionNonpsychotic major depressionHigh mortality rateMortality rateMajor depressionHospital admissionNonpsychotic depressionVital statusMedical statusCumulative Illness Rating ScaleIllness Rating ScaleMajor depressive disorderProportional hazards modelSeverity of depressionPsychotic major depressionPositive DST resultsSurvival analytic techniquesElevated mortality ratesDepressive disorderDST resultsHazards modelPatientsGreater riskRating ScaleDepression
2002
Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression
Mazure CM, Maciejewski PK, Jacobs SC, Bruce ML. Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression. American Journal Of Geriatric Psychiatry 2002, 10: 297-304. PMID: 11994217, DOI: 10.1097/00019442-200205000-00009.Peer-Reviewed Original ResearchConceptsPersonality stylesCognitive theoryBeck's cognitive theoryStressful life eventsLife eventsLife stressorsYears of educationMajor depressionDepression onsetUnipolar major depressionOnset major depressionDepressionStyleLate-onset depressionPositive associationPhysical functioningFunctioningStressorsMedical illnessControl subjectsCurrent workMultivariate modelElderly outpatientsTheory
2000
Adverse Life Events and Cognitive-Personality Characteristics in the Prediction of Major Depression and Antidepressant Response
Mazure CM, Bruce ML, Maciejewski PK, Jacobs SC. Adverse Life Events and Cognitive-Personality Characteristics in the Prediction of Major Depression and Antidepressant Response. American Journal Of Psychiatry 2000, 157: 896-903. PMID: 10831468, DOI: 10.1176/appi.ajp.157.6.896.Peer-Reviewed Original ResearchConceptsCognitive-personality stylesCognitive–personality characteristicsAdverse life eventsStressful life eventsMajor depressionLife eventsTreatment outcomesComparison subjectsDepressive onsetMultivariate modelCommunity comparison subjectsDSM-IV unipolar depressionDepressive symptom severityHealthy comparison subjectsEvent typesAntidepressant regimenAdverse eventsAntidepressant responseInterpersonal eventsAchievement eventsUnipolar depressionBetter outcomesEpisode onsetSymptom severityGroup status
1999
Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates
Weiss EL, Longhurst JG, Mazure CM. Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates. American Journal Of Psychiatry 1999, 156: 816-828. PMID: 10360118, DOI: 10.1176/ajp.156.6.816.Peer-Reviewed Original ResearchConceptsAdult-onset depressionChildhood sexual abuseEarly stressorsHPA axisSexual abuseAdrenal axis functionLong-term dysregulationMajor depressive disorderStress-induced dysregulationDepressive illnessAxis functionDepressed patientsDepressive disorderRisk factorsLong-term effectsHuman studiesManual searchNeurobiological correlatesPsychosocial mechanismsDepressionWomenEarly stressDysregulationSubsequent developmentDysregulation results
1995
Desipramine Treatment of Major Depression in Patients Over 75 Years of Age
Nelson J, Mazure C, Jatlow P. Desipramine Treatment of Major Depression in Patients Over 75 Years of Age. Journal Of Clinical Psychopharmacology 1995, 15: 99-105.. PMID: 7782495, DOI: 10.1097/00004714-199504000-00004.Peer-Reviewed Original ResearchConceptsYounger patientsYears of ageElderly patientsMajor depressionDesipramine concentrationsDrug treatmentPatient trialsAdverse reaction rateMore effective drug treatmentsEffective drug treatmentUnipolar major depressionDesipramine treatmentDepressed patientsComparable dosesPatientsSide effectsResponse rateSimilar durationTrialsSecond trialTreatmentLower ratesBloodDepressionAgeDSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity
Mazure CM, Kincare P, Schaffer CE. DSM-III-R Axis IV: Clinician Reliability and Comparability to Patients’ Reports of Stressor Severity. Psychiatry 1995, 58: 56-64. PMID: 7792323, DOI: 10.1080/00332747.1995.11024711.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAgedBipolar DisorderDementiaDepressive DisorderFemaleHumansMaleMiddle AgedPatient AdmissionPersonality AssessmentPsychiatric Status Rating ScalesPsychometricsPsychotic DisordersReproducibility of ResultsRisk FactorsSchizophreniaSchizophrenic PsychologySomatoform DisordersStress, PsychologicalConceptsPsychosocial stressorsAxis IVClinical setting todayMultiaxial diagnostic systemImportant precipitantsExacerbation of psychopathologyPatient reportsPatients' appraisalPsychiatric disordersClinical ratingsClinician reliabilityObjective ratingsSeverityExacerbationStressor severityNosological systemsReportStressorsSubjective appraisalClinicians
1994
Characteristics of desipramine-refractory depression.
Nelson JC, Mazure CM, Jatlow PI. Characteristics of desipramine-refractory depression. The Journal Of Clinical Psychiatry 1994, 55: 12-9. PMID: 8294386.Peer-Reviewed Original ResearchConceptsDepressive episodePoor responseMajor depressionNonpsychotic unipolar major depressionPrior treatment failureAdequate blood levelsWeeks of hospitalizationDrug responseUnipolar major depressionRecurrence of depressionDefinite personality disorderDiagnosis of melancholiaConsecutive inpatientsDesipramine levelsTreatment failureBlood levelsGeneral HospitalInitial severityPlasma concentrationsDrug treatmentSecondary depressionDepression InventoryPatientsPersonality disorderDepression
1992
Drug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis
Mazure C, Nelson J, Jatlow P, Bowers M. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biological Psychiatry 1991, 30: 475-482. PMID: 1932395, DOI: 10.1016/0006-3223(91)90309-a.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultBipolar DisorderChromatography, High Pressure LiquidDepressive DisorderDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPerphenazinePrognosisProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPlasma homovanillic acidHomovanillic acidFree homovanillic acidClinical responseEarly clinical responsePlasma-free homovanillic acidUseful clinical predictorClinical predictorsNeuroleptic treatmentAcute psychosisDopamine metabolismNoradrenergic functioningMethoxyhydroxyphenylglycolFavorable responsePsychotic inpatientsGood responseSignificant declineA Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression
Nelson JC, Mazure CM, Bowers MB, Jatlow PI. A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression. JAMA Psychiatry 1991, 48: 303-307. PMID: 2009031, DOI: 10.1001/archpsyc.1991.01810280019002.Peer-Reviewed Original ResearchConceptsMajor depressionMean changeHamilton Depression Rating Scale scoresDepression Rating Scale scoresCombination of fluoxetineDesipramine plasma levelsRating Scale scoresBeta-adrenergic receptorsOpen studyDesipramine levelsPlasma levelsStandardized doseScale scoreDesipramineDesipramine hydrochlorideRapid treatmentPatientsFluoxetineDrugsWeeksDepressionInpatientsTreatmentRecent studiesSame setting
1990
Value of the DST for predicting response of patients with major depression to hospitalization and desipramine
Nelson JC, Mazure CM, Jatlow PI. Value of the DST for predicting response of patients with major depression to hospitalization and desipramine. American Journal Of Psychiatry 1990, 147: 1488-1492. PMID: 2221161, DOI: 10.1176/ajp.147.11.1488.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive DisorderDesipramineDexamethasoneFemaleHospitalizationHumansHydrocortisoneMaleProbabilityPsychiatric Status Rating ScalesConceptsDexamethasone suppression testResponse of patientsMajor depressionNegative dexamethasone suppression testPositive dexamethasone suppression testWeeks of hospitalizationNonpsychotic major depressionPlasma levelsSuppression testRate of responseAntidepressant drugsDrug treatmentPatientsHospitalizationDesipraminePrior reportsDepressionResponsePrior studiesPlaceboFindingsTrialsWeeksPredictors of hospital outcome without antidepressants in major depression
Mazure C, Nelson J, Jatlow P. Predictors of hospital outcome without antidepressants in major depression. Psychiatry Research 1990, 33: 51-58. PMID: 2217658, DOI: 10.1016/0165-1781(90)90148-x.Peer-Reviewed Original ResearchConceptsWeeks of hospitalizationHospital outcomesMajor depressionNonpsychotic unipolar major depressionPersonality disorderHamilton Rating ScaleDSM-III melancholiaUnipolar major depressionConsecutive inpatientsAdmission severityHRSD scoresIndependent associationPanic disorderRating ScaleHospital responseDoes melancholia predict response in major depression?
Nelson J, Mazure C, Jatlow P. Does melancholia predict response in major depression? Journal Of Affective Disorders 1990, 18: 157-165. PMID: 2139060, DOI: 10.1016/0165-0327(90)90032-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressive DisorderDesipramineFemaleFollow-Up StudiesHospitalizationHumansMaleMiddle AgedProspective StudiesPsychiatric Status Rating Scales