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Selected Publications

Research/review articles

71. Wu H, Gao X, Luo Y, Yu J, Long G, Jiang Z, Zhou J. Targeted Delivery of Chemo-Sonodynamic Therapy via Brain Targeting, Glutathione-Consumable Polymeric Nanoparticles for Effective Brain Cancer Treatment. Advanced Science. 2022, e2203894

70. Chen AT, Xiao Y, Tang X, Baqri M, Gao X, Reschke M, Zhou Y, Deng G, Zhang S, Deng Y, Bai Z, Kim D, Huttner A, Kunes R, Saltzman WM, Fan R, Zhou J. Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion, Neuro-Oncology, 2022 noac186

69. Peng B, Zhang S, Deng G, Mohammed FS, Sheth KN, Zhou J. Oral delivery of NA1 via sumaresinolic acid NPs for stroke treatment, ACS Applied Materials & Interfaces. 2022

68. Chen X, Cuffari BJ, Shirali A, Campbell JA, Dubljevic V, Zhou J, Hansen JE. Inhibition of NETosis and metastasis by a nuclear-penetrating autoantibody, Immunohorizons, 2022, in press

67. Malewicz NM, Rattray Z, Oeck S, Jung S, Escamilla-Rivera V, Chen Z, Tang X, Zhou J, LaMotte RH, Topical capsaicin in poly(lactic-co-glycolic acid) (PLGA) nanoparticles decreases acute itch and heat pain, International Journal of Molecular Sciences, 2022, 23(9):5275

66. Zhang Y, Xu Z, Wen W, Liu Z, Zhang C, Li M, Hu F, Wei S, Bae S, Zhou J, LiuR, Wang L, The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression. Oncogene. 2022, In press

65. Liu L, Wang X, Chen AT, Gao X, Himes BT, Zhang H, Chen Z, Wang J, Sheu WC, Deng G, Xiao Y, Zou P, Zhang S, Liu F, Zhu Y, Fan R, Patel TR, Saltzman WM, Zhou J, ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage, Nature Communications, 2022, 13:2196

64. Zhang S, Peng B, Chen Z, Yu J, Deng G, Bao Y, Ma C, Du F, Sheu WC, Kimberly WT, Simard JM, Coman D, Chen Q, Hyder F, Zhou J, Sheth KN. Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery, Bioactive Materials. 2022; 16:57-65.

63. Wang C, Leavenworth J, Zhang C, Liu Z, Yuan KY, Wang Y, Zhang G, Wang S, Cui X, Zhang Y, Bae S, Zhou J, Wang L, Liu R. Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer. Oncogene. 2022 Mar 31. doi: 10.1038/s41388-022-02272-3.

62. Knier NN, Pellizzari S, Zhou J, Foster PJ, Parsyan A. Preclinical Models of Brain Metastases in Breast Cancer. Biomedicines. 2022;10(3):667.

61. Wu H, Peng B, Chen Z, Mohammed FS, Gao X, Qin Z, Sheth KN, Zhou J, Jiang Z. Brain targeting, antioxidant polymeric nanoparticles for stroke drug delivery and therapy, Small. 2022: e2107126.

60. Liu F, Peng B, Li M, Ma J, Deng G, Zhang S, Sheu WC, Zou P, Wu H, Liu J, Chen AT, Mohammed FS, Zhou J. Targeted disruption of tumor vasculature via polyphenol nanoparticles improves brain cancer treatment, Cell Reports Physical Science, 2021, 100691

59. Liu F, Wu H, Peng B, Zhang S, Ma J, Deng G, Zou P, Liu J, Chen AT, Li D, Bellone S, Santin AD, Moliterno J, Zhou J. Vessel-Targeting Nanoclovers Enable Noninvasive Delivery of Magnetic Hyperthermia-Chemotherapy Combination for Brain Cancer Treatment, Nano Letters, 2021: 21(19):8111-8118.

58. Xie Y, Ma C, Yang X, Wang J, Long G, Zhou J. Phytonanomaterials as therapeutic agents and drug delivery carriers, Adv Drug Deliv Rev. 2021:113868.

57. Rattray Z, Deng G, Zhang S, Shirali A, May CK, Chen X, Cuffari BJ, Liu J, Zou P, Rattray NJ, Johnson CH, Dubljevic V, Campbell JA, Huttner A, Baehring JM, Zhou J, Hansen JE. ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibody, JCI Insight. 2021; 6:145875.

56. Saha K, Brooks PJ, Dwinell M, Gersbach C, Liu D, Murray S, Tsai S, Wilson R, Campbell J, Chen ZY, Lagor W, Maragh S, Mirochnitchenko O, Shimoyama M, Vandsburger M, Wells K, Anderson D, Asokan A, Banfield J, Bankiewicz K, Bao G, Bulte J, Bursac N, Carlson D, Chaikof E, Cheng R, Clark K, Curiel D, Dahlman J, Deverman B, Dickinson M, Doudna J, Ekker S, Emborg M, Feng G, Freedman B, Gamm D, Gao G, Ghiran I, Glazer P, Gong S, Heaney J, Hennebold J, Hinson J, Khvorova A, Kiani S, Lam K, Leong KW, Levine J, Lewis J, Lutz C, Ly D, McCray P, McDevitt T, Morizane R, Murthy N, Prather R, Ronald J, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo P, Segal D, Skala M, Tarantal A, Tilton J, Truskey G, Watts J, Wolfe S, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium, The NIH Somatic Cell Genome Editing Program, Nature. 2021, 592(7853):195-204.

55. Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Fan L, Zhu Y, Bindra R, Hansen JE, Dou J, Huang C, Zhou J, LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy, Nature Cell Biology. 2020, In press

54. Lv Q, Cheng L, Lu Y, Zhang X, Wang Y, Deng J, Zhou J, Liu B, Liu J. Thermosensitive Exosome-liposome Hybrid Nanoparticle-mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer. Advanced Science. 2020,

53. Ma J, Liu F, Sheu WC, Meng Z, Xie Y, Xu H, Li M, Chen AT, Liu J, Bao Y, Zhang X, Zhang S, Zhang L, Zou Z, Wu H, Wang H, Zhu Y, Zhou J, Co-presentation of Tumor Antigens and Costimulatory Molecules via Biomimetic Nanoparticles for Effective Cancer Immunotherapy, Nano Letters, 2020, 20(6):4084-4094.

52. Li S, Su W, Wu H, Yuan T, Yuan C, Liu J, Deng G, Gao X, Chen Z, Bao Y, Yuan F, Zhou S, Tan H, Li Y, Li X, Fan L, Zhu J, Chen AT, Liu F, Zhou Y, Li M, Zhai X, Zhou J, Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids. Nature Biomedical Engineering. 2020, In press. doi: 10.1038/s41551-020-0540-y

51. Zhang S, Deng G, Liu F, Bao Y, Du F, Chen AT, Liu J, Chen Z, Ma J, Tang X, Sheu WC, Chen Q, Zhou J, Autocatalytic Delivery of Brain Tumor-targeting, Size-shrinkable Nanoparticles for Treatment of Breast Cancer Brain Metastases, Advanced Functional Materials. 2020, 1910651

50. Zhou Y, Chen Z, Bao Y, Chen AT, Sheu WC, Liu F, Jiang Z, Zhou J, Targeted Delivery of Secretory Pro-melittin via Novel Poly(lactone-co-β-amino ester) Nanoparticles for Treatment of Breast Cancer Brain Metastases, Advanced Science. 2020, 1901866

49. Bao Y, Zhang S, Chen Z, Chen AT, Ma J, Deng G, Xu W, Zhou J, Yu ZQ, Yao G, Chen J. Synergistic Chemotherapy for Breast Cancer and Breast Cancer Brain Metastases via Paclitaxel-Loaded Oleanolic Acid Nanoparticles. Mol Pharm. 2020;17(4):1343-1351.

48. Leier A, Korf B, Zhou J, Kesterson RA, Muller U, Keeling K, Bedwell, Dickson G, Popplewell L, Wallis D, Mutation Directed Therapeutics for Neurofibromatosis Type I, Molecular Therapy - Nucleic Acids. 2020, 20:739-753

47. Zhang H, Zhu H, Deng G, Zito CR, Oria VO, Rane CK, Zhang S, Weiss SA, Tran T, Adeniran A, Zhang F, Zhou J, Kluger Y, Bosenberg MW, Kluger KM, Jilaveanu LB, PLEKHA5 Regulates Tumor Growth in Metastatic Melanoma, Cancer. 2019 Nov 26. doi: 10.1002/cncr.32611.

46. Deng G, Ma C, Zhao H, Zhang S, Liu J, Liu F, Chen Z, Chen AT, Yang X, Avery J, Zou P, Du F, Lim KP, Holden D, Li S, Carson RE, Huang Y, Chen Q, Sheth KN, Zhou J, Anti-edema and antioxidant combination therapy for ischemic stroke via glyburide-loaded betulinic acid nanoparticles, Theranostics. 2019, 9, 6991-7002

45. Zhou Y, Peng J, Cheng L, Peng Y, Zhang M, Liu M, Avery J, Zhou J, Jiang Y. Secreted protein acidic and cysteine rich (SPARC) regulates the pathological response to ischemic insults and represents a promising therapeutic target for stroke treatment, Advanced Therapeutics. 2019, 2, 1900082

44. Yang X, Ma C, Liu J, Liu F, Xie R, Zhao H, Chen Z, Deng G, Chen AT, Gong N, Yao Y, Zuo P, Zhi K, Wang J, Gao X, Wang J, Fan L, Zhou J, Single small molecule- assembled supramolecular nanoparticles mediate efficient oral drug delivery. Nano Research. 2019, 12, 2468-2476

43. Ma J, Zhang S, Liu J, Liu F, Du F, Li M, Chen AT, Bao Y, Suh HW, Avery J, Deng G, Zhou Y, Wu P, Sheth K, Wang H, Zhou J, Targeted drug delivery to stroke via chemotactic recruitment of nanoparticles coated with membrane of engineered neural stem cells, Small. 2019, 15, 1902011

42. Xiao Y, Kim D, Dura B, Zhang K, Yan R, Li H, Han E, Ip J, Zou P, Liu J, Chen AT, Vortmeyer AO, Zhou J, Fan R. Ex vivo dynamics of human glioblastoma cells in a microvasculature-on-a-chip system correlates with tumor heterogeneity and subtypes. 2018. Advanced Science. 2019, 1801531

41. Yuan F, LI Y, Li X, Fan L, Zhou S, Zhou J, Nitrogen rich D-π-A structural carbon quantum dots with bright two-photon fluorescence for deep-tissue imaging. 2018. ACS Applied Bio Materials. 2018, 1 (3), pp 853–858

40. Jacobs D, Qin Q, Fu Al. Chen Z, Zhou J, Zhu Y. piRNA-8041 is downregulated in human glioblastoma and suppresses tumor growth in vitro and in vivo. Oncotarget. 2018 9: 37616-37626

39. Guo X, Deng G, Liu J, Zou P, Liu F, Chen AT, Du F, Tang Z, Han L, Liu J, Sheth KN, Chen Q, Gou X, Zhou J, Thrombin-responsive, brain-targeting nanoparticles for improved stroke therapy. ACS Nano. 2018;12(8):8723-8732

38. Kranz M, Bergmann R, Kniess T, Belter B, Neuber C, Cai Z, Deng G, Fischer S, Zhou J, Huang Y, Brust P, Deuther-Conrad W, Pietzsch J. Bridging from Brain to Tumor Imaging: (S)-(-)- and (R)-(+)-[18F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice. Molecules. 2018 Mar 20;23(3)

37. Wang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH, Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice. Neurosci Lett. 2018; 668:154-158

36. Yu X, Gou X, Wu P, Han L, Tian D, Du F, Chen Z, Liu F, Deng G, Chen AT, Ma C, Liu J, Hashmi SM, Guo X, Wang X, Zhao H, Liu X, Zhu X, Sheth K, Chen Q, Fan L, Zhou J, Activatable protein nanoparticles for targeted delivery of therapeutic peptides, Advanced Materials, 2018, 1705383

35. Chen Z, Liu F, Chen Y, Liu J, Wang X, Chen A, Deng G, Liu J, Hong Z, Zhou J, Targeted delivery of CRISPR/Cas9-mediated cancer gene therapy via liposome-templated hydrogel nanoparticles. Advanced Functional Materials, 2017, 1703036

34. Mi Y, Chen H, Guo N, Sun M, Zhao Z, Gao X, Wang X, Zhang R, Zhou J, Gou X, Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive Behavior. Frontiers in Aging Neuroscience, 2017; 9

33. Fan Z, Zhou S, Garcia C, Fan L, Zhou J, pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis. Nanoscale. 2017;9(15):4928-33.

32. Chen Y, Su M, Li Y, Gao J, Zhang C, Cao Z, Zhou J, Liu J, Jiang Z. Enzymatic PEG-Poly(amine-co-disulfide ester) Nanoparticles as pH- and Redox-Responsive Drug Nanocarriers for Efficient Antitumor Treatment. ACS Appl Mater Interfaces, 2017; 9:30519

31. Chen Z, Patel JM, Noble PW, Garcia C, Hong Z, Hansen JE, Zhou J, A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors, Oncotarget. 2016; 7(37):59965-75.

30. Han L, Cai Q, Tian D, Kong D, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J, Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles, Nanomedicine, 2016;12(7):1833-42.

29. Han L, Kong D, Zheng MQ, Murikinati S, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J, Increased nanoparticle delivery to brain tumors by autocatalytic priming for improved treatment and imaging, ACS Nano, 2016;10(4):4209-18.

28. John SF, Aniemeke E, Ha NP, Chong CR, Gu P, Zhou J, Zhang Y, Graviss EA, Liu JO, Olaleye OA, Characterization of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone as a novel inhibitor of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis, 2016;101:S73-7

27. Chen Y, Gou X, Kong DK, Wang X, Wang J, Chen Z, Huang C, Zhou J. EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Oncotarget. 2015;6(32):32575-85.

26. Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, Zhou J. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. Journal of Neuro-Oncology. 2015;121(3):441-9.

25. Cai Q, Chen Z, Kong DK, Wang J, Xu Z, Liu B, Chen Q, Zhou J, Novel microcatheter-based intracarotid delivery approach for MCAO/R mice. Neuroscience Letters. 2015;597: 127-31.

24. Ediriwickrema A, Zhou J, Deng Y, Saltzman WM. Multi-layered nanoparticles for combination gene and drug delivery to tumors. Biomaterials. 2014;35(34):9343-54.

23. Sirianni RW, Zheng MQ, Patel TR, Shafbauer T, Zhou J, Saltzman WM, Carson RE, Huang Y. Radiolabeling of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with biotinylated F-18 prosthetic groups and imaging of their delivery to the brain with positron emission tomography. Bioconjugate Chemistry. 2014;25(12):2157-65.

22. Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng M-Q, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ, Jr., Piepmeier JM, Saltzman WM. Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proceedings of the National Academy of Sciences). 2013;110(29):11751-6.

21. Zhou J, Liu J, Cheng CJ, Patel TR, Weller CE, Piepmeier JM, Jiang Z, Saltzman WM. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials. 2012;11(1):82-90.

20. Zhou J, Patel TR, Fu M, Bertram JP, Saltzman WM. Octa-functional PLGA nanoparticles for targeted and efficient siRNA delivery to tumors. Biomaterials. 2012;33(2):583-91.

19. Zhou J, Atsina KB, Himes BT, Strohbehn GW, Saltzman WM. Novel delivery strategies for glioblastoma. Cancer Journal. 2012;18(1):89-99.

18. Patel T, Zhou J, Piepmeier JM, Saltzman WM. Polymeric nanoparticles for drug delivery to the central nervous system. Advanced Drug Delivery Reviews. 2012;64(7):701-5.

17. Liu J, Jiang ZZ, Zhou J, Zhang SM, Saltzman WM. Enzyme-synthesized poly(amine-co-esters) as nonviral vectors for gene delivery. Journal of Biomedical Materials Research Part A. 2011;96(2):456-65.

16. Olaleye O, Raghunand TR, Bhat S, Chong C, Gu P, Zhou J, Zhang Y, Bishai WR, Liu JO. Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis. Tuberculosis, 2011;91: S61-5

15. Zhou J, Zhang H, Gu P, Margolick JB, Yin D, Zhang Y. Cancer stem/progenitor cell active compound 8-quinolinol in combination with paclitaxel achieves an improved cure of breast cancer in the mouse model. Breast Cancer Research and Treatment. 2009;115(2):269-77.

14. Zhou J, Zhang Y. Preclinical development of cancer stem cell drugs. Expert Opinion on Drug Discovery. 2009;4(7):741-52.

13. Zhou J, Zhang Y. Cancer stem cells: Models, mechanisms and implications for improved treatment. Cell Cycle. 2008;7(10):1360-70.

12. Tao SC, Li Y, Zhou J, Qian J, Schnaar RL, Zhang Y, Goldstein IJ, Zhu H, Schneck JP. Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers. Glycobiology. 2008;18(10):761-9.

11. Zhou J, Zhang H, Gu P, Bai J, Margolick JB, Zhang Y. NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells. Breast Cancer Research and Treatment. 2008;111(3):419-27.

10. Ma C, Zhou J, Yin X, Jie C, Xing D, Du L, Zhang Y. Mycobacterium tuberculosis Culture Supernatant Induces Cancer Cell Apoptosis and Cell Cycle Arrest. The Open Cancer Journal, 2008;18(10):761-9.

9. Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Deng J, Margolick JB, Liotta LA, Petricoin E, 3rd, Zhang Y. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proceedings of the National Academy of Sciences. 2007;104(41):16158-63.

8. Byrne ST, Gu P, Zhou J, Denkin SM, Chong C, Sullivan D, Liu JO, Zhang Y. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 2007; 51(12):4495-7.

7. Yin X, Zhou J, Jie C, Xing D, Zhang Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Science. 2004;75(18):2233-44.

6. Zhang H, Wang Z, Zhou J. Cytoplasm prepared from all-trans retinoic acid (ATRA)-treated human hematopoietic progenitor cells induces differentiation of both ATRA sensitive and ATRA resistant leukemia cells. Biological and Pharmaceutical Bulletin, 2004;27(4):570-3.

5. Liu M, Wang Z, Ju Y, Zhou J, Wang Y, Wong RNS. The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines. Biotechnology and Applied Biochemistry. 2004, 27:1059-65.

4. Zhou J, Wang Z, Sun S, Liu M, Zhang H. A rapid method for detecting conformational changes during differentiation and apoptosis of HL60 cells by Fourier-transform infrared spectroscopy. Biotechnology and Applied Biochemistry. 2001, 33:127-32.

3. Wang Z, Zhou J, Ju Y. Liu M, Toxicity and tumor cell growth inhibition ability of dioscin, methyl protodiosicn and diosgenin extracted from Polygnotum Zanlanscianse Pamp. Tsinghua Science and Technology, 2001, 6(3): 239-42

2. Wang Z, Zhou J, Sun S. Zhang H, Conformational changes in Human Leukemia HL60 Cells induced differentiation and apoptosis by Genistein. Tsinghua Science and Technology, 2001, 6(3): 242-47

1. Wang Z, Zhou J, Ju Y, Zhang H, Liu M, Li X. Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells. Biotechnology and Applied Biochemistry. 2001; 24(2):159-62.

Book Chapters

3. Chen Z, Chen AT, Zhou J. Targeted delivery of CRISPR/Cas9 to brain tumors. Nanotherapy for Brain Tumor Drug Delivery, Springer

2. Du F, Zhou J, Vascular intervention: from angioplasty to bioresorbable vascular scaffold, Molecular, Cellular and Tissue Engineering of the Vascular System, Springer

1. Wu X, Zhou J, Patel T. Generation of ultra-small PLGA nanoparticles by sequential centrifugation. Targeted drug delivery: methods and protocol, Springer