Sabine Martha Lang, PhD
she/her/hers
Associate Research Scientist in PathologyCards
About
Research
Publications
Featured Publications
Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition
Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q. Acquired Resistance to HER2-Targeted Therapies Creates Vulnerability to ATP Synthase Inhibition. Cancer Research 2020, 80: 524-535. PMID: 31690671, PMCID: PMC7002225, DOI: 10.1158/0008-5472.can-18-3985.Peer-Reviewed Original ResearchAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisBreast NeoplasmsCell ProliferationDrug Resistance, NeoplasmEnzyme InhibitorsFemaleHumansMiceMice, Inbred NODMice, SCIDMitochondrial Proton-Translocating ATPasesOligomycinsReceptor, ErbB-2TrastuzumabTumor Cells, CulturedXenograft Model Antitumor AssaysKDM5 histone demethylases repress immune response via suppression of STING
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLOS Biology 2018, 16: e2006134. PMID: 30080846, PMCID: PMC6095604, DOI: 10.1371/journal.pbio.2006134.Peer-Reviewed Original ResearchKDM5 lysine demethylases are involved in maintenance of 3′UTR length
Blair LP, Liu Z, Labitigan RL, Wu L, Zheng D, Xia Z, Pearson EL, Nazeer FI, Cao J, Lang SM, Rines RJ, Mackintosh SG, Moore CL, Li W, Tian B, Tackett AJ, Yan Q. KDM5 lysine demethylases are involved in maintenance of 3′UTR length. Science Advances 2016, 2: e1501662. PMID: 28138513, PMCID: PMC5262454, DOI: 10.1126/sciadv.1501662.Peer-Reviewed Original ResearchMitochondrial DNA stress primes the antiviral innate immune response
West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 2015, 520: 553-557. PMID: 25642965, PMCID: PMC4409480, DOI: 10.1038/nature14156.Commentaries, Editorials and LettersKaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR
Lang SM, Bynoe MO, Karki R, Tartell MA, Means RE. Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR. PLOS ONE 2013, 8: e58056. PMID: 23460925, PMCID: PMC3584050, DOI: 10.1371/journal.pone.0058056.Peer-Reviewed Original ResearchAmino Acid MotifsCell Adhesion MoleculesCell MembraneDown-RegulationEndocytosisHEK293 CellsHerpesvirus 8, HumanHumansImmunoprecipitationLectins, C-TypeLysosomesProteasome Endopeptidase ComplexProtein StabilityProtein Structure, TertiaryProteolysisReceptors, Cell SurfaceStructure-Activity RelationshipTyrosineUbiquitinationViral Proteins
2024
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.
McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.Peer-Reviewed Original Research
2022
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Zhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. Science Translational Medicine 2022, 14: eabf5473-eabf5473. PMID: 35108062, PMCID: PMC9003667, DOI: 10.1126/scitranslmed.abf5473.Peer-Reviewed Original Research
2012
The PreAmplifier ShAper for the ALICE TPC detector
Soltveit H, Stachel J, Braun-Munzinger P, Musa L, Gustafsson H, Bonnes U, Oeschler H, Osterman L, Lang S, Collaboration F. The PreAmplifier ShAper for the ALICE TPC detector. Nuclear Instruments And Methods In Physics Research Section A Accelerators Spectrometers Detectors And Associated Equipment 2012, 676: 106-119. DOI: 10.1016/j.nima.2012.02.012.Peer-Reviewed Original Research
2011
Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor
Cardenas I, Means R, Aldo P, Koga K, Lang S, Booth C, Manzur A, Oyarzun E, Romero R, Mor G. Corrections: Viral Infection of the Placenta Leads to Fetal Inflammation and Sensitization to Bacterial Products Predisposing to Preterm Labor. The Journal Of Immunology 2011, 187: 2835-2835. DOI: 10.4049/jimmunol.1190048.Commentaries, Editorials and Letters
2010
The Kaposi's sarcoma-associated herpesvirus E3 ubiquitin ligase K5 acts as a novel oncogene, altering cellular metabolism and signaling: implications for tumorigenesis
Karki R, Lang S, Means R. The Kaposi's sarcoma-associated herpesvirus E3 ubiquitin ligase K5 acts as a novel oncogene, altering cellular metabolism and signaling: implications for tumorigenesis. Infectious Agents And Cancer 2010, 5: a79. PMCID: PMC3002742, DOI: 10.1186/1750-9378-5-s1-a79.Peer-Reviewed Original Research
Get In Touch
Contacts
Email
Academic Office Number
Office Fax Number
Mailing Address
Pathology
310 Cedar Street, LH 304
New Haven, CT 06524-8023
United States
Locations
Department of Pathology
Academic Office
Lauder Hall
310 Cedar Street, Ste LH 304
New Haven, CT 06510
Fax
203.785.6127Appointments
203.785.7614