Publications

2026

Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells.
Quiñones-Avilés Y, Salovska B, Markham CS, Di Y, Turk BE, Liu Y, Muzumdar MD. Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells. BioRxiv 2026 PMID: 41959224, DOI: 10.64898/2026.03.10.710185.
Peer-Reviewed Original Research

2024

Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.
McGeary M, Damsky W, Daniels A, Lang S, Xu Q, Song E, Huet-Calderwood C, Lou H, Paradkar S, Micevic G, Kaech S, Calderwood D, Turk B, Yan Q, Iwasaki A, Bosenberg M. Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma. Cancer Immunology Research 2024, 13: 245-257. PMID: 39589394, DOI: 10.1158/2326-6066.cir-23-0514.
Peer-Reviewed Original Research
Concepts
Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes
Ballmer D, Lou H, Ishii M, Turk B, Akiyoshi B. Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes. Journal Of Cell Biology 2024, 223: e202401169. PMID: 39196069, PMCID: PMC11354203, DOI: 10.1083/jcb.202401169.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells
Zhang H, Read A, Cataisson C, Yang H, Lee W, Turk B, Yuspa S, Luo J. Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells. Science Signaling 2024, 17: eadd5073-eadd5073. PMID: 38743809, PMCID: PMC11238902, DOI: 10.1126/scisignal.add5073.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The intrinsic substrate specificity of the human tyrosine kinome
Yaron-Barir T, Joughin B, Huntsman E, Kerelsky A, Cizin D, Cohen B, Regev A, Song J, Vasan N, Lin T, Orozco J, Schoenherr C, Sagum C, Bedford M, Wynn R, Tso S, Chuang D, Li L, Li S, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry S, Uduman M, Blenis J, Elemento O, Frame M, Hornbeck P, Cantley L, Turk B, Yaffe M, Johnson J. The intrinsic substrate specificity of the human tyrosine kinome. Nature 2024, 629: 1174-1181. PMID: 38720073, PMCID: PMC11136658, DOI: 10.1038/s41586-024-07407-y.
Peer-Reviewed Original Research
Concepts
Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Sexton J, Potchernikov T, Bibeau J, Casanova-Sepúlveda G, Cao W, Lou H, Boggon T, De La Cruz E, Turk B. Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail. Nature Communications 2024, 15: 1426. PMID: 38365893, PMCID: PMC10873347, DOI: 10.1038/s41467-024-45878-9.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells
Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, Luan Y, Calderwood D, Turk B, Tang W, Liu Y, Wu D. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nature Communications 2024, 15: 603. PMID: 38242867, PMCID: PMC10798966, DOI: 10.1038/s41467-024-44885-0.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2023

2022

2021

2020

2019

Ancestral reconstruction reveals mechanisms of ERK regulatory evolution
Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ. Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. ELife 2019, 8: e38805. PMID: 31407663, PMCID: PMC6692128, DOI: 10.7554/elife.38805.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

See All Publications

Publications

2026

Baseline cellular state dictates the molecular impact of KRAS mutant variants in pancreatic cancer cells.

2025

Cancer hotspot mutations rewire ERK2 specificity by selective exclusion of docking interactions

2024

Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.

Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes

Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells

The intrinsic substrate specificity of the human tyrosine kinome

Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail

The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

2023

Autoregulation of the LIM kinases by their PDZ domain

Linear motif specificity in signaling through p38α and ERK2 mitogen–activated protein kinases

An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells

An atlas of substrate specificities for the human serine/threonine kinome

Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors

2022

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism

Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry

2021

Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function

Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast

Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin

2020

Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding

Recognition of physiological phosphorylation sites by p21-activated kinase 4

2019

Ancestral reconstruction reveals mechanisms of ERK regulatory evolution