Publications

• Setdb1-loss induces type-I interferons and immune clearance of melanoma.McGeary MK, Damsky W, Daniels AJ, Lang SM, Xu Q, Song E, Huet-Calderwood C, Lou HJ, Paradkar S, Micevic G, Kaech SM, Calderwood DA, Turk BE, Yan Q, Iwasaki A, Bosenberg MW. Cancer Immunol Res. 2024 Nov 26; 2024 Nov 26. PMID: 39589394.
• Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes.Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. J Cell Biol. 2024 Nov 4; 2024 Aug 28. PMID: 39196069.
• Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS- and BRAF-mutant cancer cells.Zhang H, Read A, Cataisson C, Yang HH, Lee WC, Turk BE, Yuspa SH, Luo J. Sci Signal. 2024 May 14; 2024 May 14. PMID: 38743809.
• The intrinsic substrate specificity of the human tyrosine kinome.Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin TY, Orozco JM, Schoenherr C, Sagum C, Bedford MT, Wynn RM, Tso SC, Chuang DT, Li L, Li SS, Creixell P, Krismer K, Takegami M, Lee H, Zhang B, Lu J, Cossentino I, Landry SD, Uduman M, Blenis J, Elemento O, Frame MC, Hornbeck PV, Cantley LC, Turk BE, Yaffe MB, Johnson JL. Nature. 2024 May; 2024 May 8. PMID: 38720073.
• Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail.Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sepúlveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM, Turk BE. Nat Commun. 2024 Feb 16; 2024 Feb 16. PMID: 38365893.
• An unconventional regulatory circuitry involving Aurora B controls anaphase onset and error-free chromosome segregation in trypanosomes.Ballmer D, Lou HJ, Ishii M, Turk BE, Akiyoshi B. bioRxiv. 2024 Jan 20; 2024 Jan 20. PMID: 38293145.
• Autoregulation of the LIM kinases by their PDZ domain.Casanova-Sepúlveda G, Sexton JA, Turk BE, Boggon TJ. Nat Commun. 2023 Dec 19; 2023 Dec 19. PMID: 38114480.
• Linear motif specificity in signaling through p38α and ERK2 mitogen-activated protein kinases.Torres Robles J, Lou HJ, Shi G, Pan PL, Turk BE. Proc Natl Acad Sci U S A. 2023 Nov 28; 2023 Nov 21. PMID: 37988460.
• Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail.Sexton JA, Potchernikov T, Bibeau JP, Casanova-Sepúlveda G, Cao W, Lou HJ, Boggon TJ, De La Cruz EM, Turk BE. bioRxiv. 2023 Jul 9; 2023 Jul 9. PMID: 37425676.
• An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells.Zhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk BE, Sessa WC, Liu Y. Nat Commun. 2023 Jun 26; 2023 Jun 26. PMID: 37365174.
• Setdb1 -loss induces type-I interferons and immune clearance of melanoma.McGeary MK, Damsky W, Daniels A, Song E, Micevic G, Huet-Calderwood C, Lou HJ, Paradkar S, Kaech S, Calderwood DA, Turk BE, Iwasaki A, Bosenberg MW. bioRxiv. 2023 May 24; 2023 May 24. PMID: 37292991.
• Proteome-wide screening for mitogen-activated protein kinase docking motifs and interactors.Shi G, Song C, Torres Robles J, Salichos L, Lou HJ, Lam TT, Gerstein M, Turk BE. Sci Signal. 2023 Jan 10; 2023 Jan 10. PMID: 36626580.
• An atlas of substrate specificities for the human serine/threonine kinome.Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Nature. 2023 Jan; 2023 Jan 11. PMID: 36631611.
• Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.Stork BA, Dean A, Ortiz AR, Saha P, Putluri N, Planas-Silva MD, Mahmud I, Rajapakshe K, Coarfa C, Knapp S, Lorenzi PL, Kemp BE, Turk BE, Scott JW, Means AR, York B. Mol Metab. 2022 Aug; 2022 May 11. PMID: 35562082.
• Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.Simon B, Lou HJ, Huet-Calderwood C, Shi G, Boggon TJ, Turk BE, Calderwood DA. Nat Commun. 2022 Feb 8; 2022 Feb 8. PMID: 35136069.
• Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.Schiapparelli P, Pirman NL, Mohler K, Miranda-Herrera PA, Zarco N, Kilic O, Miller C, Shah SR, Rogulina S, Hungerford W, Abriola L, Hoyer D, Turk BE, Guerrero-Cázares H, Isaacs FJ, Quiñones-Hinojosa A, Levchenko A, Rinehart J. Cell Rep. 2021 Jul 20. PMID: 34289367.
• TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J. Cancer Discov. 2021 Jun; 2021 Jan 25. PMID: 33495197.
• Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.Ghosh C, Uppala JK, Sathe L, Hammond CI, Anshu A, Pokkuluri PR, Turk BE, Dey M. Sci Signal. 2021 May 25; 2021 May 25. PMID: 34035143.
• PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.Cho E, Lou HJ, Kuruvilla L, Calderwood DA, Turk BE. Cell Rep. 2021 Mar 30. PMID: 33789117.
• Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.Komolov KE, Sulon SM, Bhardwaj A, van Keulen SC, Duc NM, Laurinavichyute DK, Lou HJ, Turk BE, Chung KY, Dror RO, Benovic JL. Mol Cell. 2021 Jan 21; 2020 Dec 14. PMID: 33321095.
• Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.Zhou M, Kuruvilla L, Shi X, Viviano S, Ahearn IM, Amendola CR, Su W, Badri S, Mahaffey J, Fehrenbacher N, Skok J, Schlessinger J, Turk BE, Calderwood DA, Philips MR. Proc Natl Acad Sci U S A. 2020 Dec 15; 2020 Nov 30. PMID: 33257571.
• Recognition of physiological phosphorylation sites by p21-activated kinase 4.Chetty AK, Sexton JA, Ha BH, Turk BE, Boggon TJ. J Struct Biol. 2020 Sep 1; 2020 Jun 23. PMID: 32585314.
• A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding.Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A Jr, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG. Sci Adv. 2020 Jun; 2020 Jun 24. PMID: 32637600.
• Ancestral reconstruction reveals mechanisms of ERK regulatory evolution.Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ. Elife. 2019 Aug 13; 2019 Aug 13. PMID: 31407663.
• Global view of the RAF-MEK-ERK module and its immediate downstream effectors.Santini CC, Longden J, Schoof EM, Simpson CD, Jeschke GR, Creixell P, Kim J, Wu X, Turk BE, Rosen N, Poulikakos PI, Linding R. Sci Rep. 2019 Jul 26; 2019 Jul 26. PMID: 31350469.
• Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.van de Kooij B, Creixell P, van Vlimmeren A, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Elife. 2019 May 24; 2019 May 24. PMID: 31124786.
• Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. PLoS Biol. 2019 Mar; 2019 Mar 21. PMID: 30897078.
• Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase Interacts with a Subunit of the Parasite Proteasome.Govindasamy K, Khan R, Snyder M, Lou HJ, Du P, Kudyba HM, Muralidharan V, Turk BE, Bhanot P. Infect Immun. 2019 Jan; 2018 Dec 19. PMID: 30323024.
• Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor.Turk BE. Adv Exp Med Biol. 2019. PMID: 30267305.
• Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S. Front Immunol. 2018; 2018 Dec 4. PMID: 30568657.
• Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE. J Biol Chem. 2018 Nov 23; 2018 Oct 10. PMID: 30305396.
• Kinase Substrate Profiling Using a Proteome-wide Serine-Oriented Human Peptide Library.Barber KW, Miller CJ, Jun JW, Lou HJ, Turk BE, Rinehart J. Biochemistry. 2018 Aug 7; 2018 Jun 19. PMID: 29920078.
• Homing in: Mechanisms of Substrate Targeting by Protein Kinases.Miller CJ, Turk BE. Trends Biochem Sci. 2018 May; 2018 Mar 12. PMID: 29544874.
• In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates.Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL. Biochemistry. 2018 Mar 27; 2018 Mar 12. PMID: 29528224.
• Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL. Elife. 2018 Feb 26; 2018 Feb 26. PMID: 29480805.
• Glycogen synthase kinase-3β regulation: another kinase gets in on the AKT.Turk BE. FEBS Lett. 2018 Feb; 2018 Feb 8. PMID: 29417553.
• A high throughput assay to identify substrate-selective inhibitors of the ERK protein kinases.Miller CJ, Muftuoglu Y, Turk BE. Biochem Pharmacol. 2017 Oct 15; 2017 Jun 21. PMID: 28647489.
• Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine.Advani G, Lim YC, Catimel B, Lio DSS, Ng NLY, Chüeh AC, Tran M, Anasir MI, Verkade H, Zhu HJ, Turk BE, Smithgall TE, Ang CS, Griffin M, Cheng HC. Cell Commun Signal. 2017 Aug 7; 2017 Aug 7. PMID: 28784162.
• Rational Redesign of a Functional Protein Kinase-Substrate Interaction.Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE. ACS Chem Biol. 2017 May 19; 2017 Mar 29. PMID: 28314095.
• Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase.Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E. Mol Cell Biol. 2017 May 15; 2017 May 2. PMID: 28223369.
• Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J. Sci Rep. 2017 Apr 20; 2017 Apr 20. PMID: 28428613.
• Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE. J Biol Chem. 2017 Jan 20; 2016 Dec 1. PMID: 27909054.
• Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-β-dependent mechanisms.Shi X, Mihaylova VT, Kuruvilla L, Chen F, Viviano S, Baldassarre M, Sperandio D, Martinez R, Yue P, Bates JG, Breckenridge DG, Schlessinger J, Turk BE, Calderwood DA. Proc Natl Acad Sci U S A. 2016 Aug 2; 2016 Jul 18. PMID: 27432991.
• Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. ACS Chem Biol. 2016 Jun 17; 2016 Mar 31. PMID: 26999302.
• Control of serotonin transporter phosphorylation by conformational state.Zhang YW, Turk BE, Rudnick G. Proc Natl Acad Sci U S A. 2016 May 17; 2016 May 2. PMID: 27140629.
• Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.Hamill S, Lou HJ, Turk BE, Boggon TJ. Mol Cell. 2016 May 5. PMID: 27153537.
• Inhibitors of the Metalloproteinase Anthrax Lethal Factor.Goldberg AB, Turk BE. Curr Top Med Chem. 2016. PMID: 27072692.
• Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries.Miller CJ, Turk BE. Methods Mol Biol. 2016. PMID: 26501912.
• Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays.Deng Y, Turk BE. Methods Mol Biol. 2016. PMID: 26490465.
• Unmasking determinants of specificity in the human kinome.Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388442.
• Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R. Cell. 2015 Sep 24; 2015 Sep 17. PMID: 26388441.
• Comparative Analysis of Two Gene-Targeting Approaches Challenges the Tumor-Suppressive Role of the Protein Kinase MK5/PRAK.Ronkina N, Johansen C, Bohlmann L, Lafera J, Menon MB, Tiedje C, Laaß K, Turk BE, Iversen L, Kotlyarov A, Gaestel M. PLoS One. 2015; 2015 Aug 21. PMID: 26295581.
• Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. Nat Commun. 2015 Aug 3; 2015 Aug 3. PMID: 26235885.
• Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ. Mol Cell. 2015 Jul 16; 2015 Jun 25. PMID: 26118643.
• Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.Osman KT, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui R. Mol Biochem Parasitol. 2015 Jun; 2015 Jun 22. PMID: 26112892.
• Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.Ha BH, Morse EM, Turk BE, Boggon TJ. J Biol Chem. 2015 May 22; 2015 Apr 8. PMID: 25855792.
• Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ. Elife. 2014 Oct 13; 2014 Oct 13. PMID: 25310241.
• Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.Deng Y, Alicea-Velázquez NL, Bannwarth L, Lehtonen SI, Boggon TJ, Cheng HC, Hytönen VP, Turk BE. J Proteome Res. 2014 Oct 3; 2014 Aug 28. PMID: 25164267.
• Identification of cleavage sites leading to the shed form of the anti-aging protein klotho.Chen CD, Tung TY, Liang J, Zeldich E, Tucker Zhou TB, Turk BE, Abraham CR. Biochemistry. 2014 Sep 2; 2014 Aug 20. PMID: 25110992.
• An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. Mol Cell. 2014 Aug 7; 2014 Jul 17. PMID: 25042806.
• Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Proc Natl Acad Sci U S A. 2014 Jul 22; 2014 Jul 7. PMID: 25002506.
• Modulation of the chromatin phosphoproteome by the Haspin protein kinase.Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R. Mol Cell Proteomics. 2014 Jul; 2014 Apr 14. PMID: 24732914.
• The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD. Cell Host Microbe. 2014 May 14. PMID: 24832449.
• Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, Ammerer G, Peter M, Kraft C. Mol Cell. 2014 Feb 6; 2014 Jan 16. PMID: 24440502.
• Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE. Mol Cell. 2014 Jan 9; 2013 Dec 26. PMID: 24374310.
• Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ. PLoS One. 2013; 2013 Oct 28. PMID: 24204982.
• mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. Science. 2013 Jul 26. PMID: 23888043.
• Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity.Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M. J Am Chem Soc. 2013 Jun 19; 2013 Jun 6. PMID: 23701445.
• Construction of human activity-based phosphorylation networks.Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. Mol Syst Biol. 2013. PMID: 23549483.
• Exploiting the unique ATP-binding pocket of toxoplasma calcium-dependent protein kinase 1 to identify its substrates.Lourido S, Jeschke GR, Turk BE, Sibley LD. ACS Chem Biol. 2013; 2013 Apr 10. PMID: 23530747.
• A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.Deng Y, Couch BA, Koleske AJ, Turk BE. Chembiochem. 2012 Nov 26; 2012 Oct 18. PMID: 23081945.
• Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.Lee YJ, Jeschke GR, Roelants FM, Thorner J, Turk BE. Mol Cell Biol. 2012 Nov; 2012 Sep 17. PMID: 22988299.
• Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Cell Signal. 2012 Nov; 2012 Jul 11. PMID: 22796189.
• Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G. J Biol Chem. 2012 Oct 19; 2012 Aug 31. PMID: 22942288.
• Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Proc Natl Acad Sci U S A. 2012 Oct 2; 2012 Sep 17. PMID: 22988085.
• Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.Bannwarth L, Goldberg AB, Chen C, Turk BE. Chem Biol. 2012 Jul 27. PMID: 22840775.
• Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR. Proc Natl Acad Sci U S A. 2012 Mar 13; 2012 Feb 27. PMID: 22371566.
• Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli.Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Protein Expr Purif. 2011 Oct; 2011 May 14. PMID: 21605678.
• Identification of specificity determining residues in peptide recognition domains using an information theoretic approach applied to large-scale binding maps.Yip KY, Utz L, Sitwell S, Hu X, Sidhu SS, Turk BE, Gerstein M, Kim PM. BMC Biol. 2011 Aug 11; 2011 Aug 11. PMID: 21835011.
• Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC. Biochemistry. 2011 Aug 9; 2011 Jul 18. PMID: 21699177.
• Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.Kikani CK, Antonysamy SA, Bonanno JB, Romero R, Zhang FF, Russell M, Gheyi T, Iizuka M, Emtage S, Sauder JM, Turk BE, Burley SK, Rutter J. J Biol Chem. 2010 Dec 24; 2010 Oct 13. PMID: 20943661.
• Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD. Cell Host Microbe. 2010 Dec 16. PMID: 21147463.
• The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover.Sirichandra C, Davanture M, Turk BE, Zivy M, Valot B, Leung J, Merlot S. PLoS One. 2010 Nov 10; 2010 Nov 10. PMID: 21085673.
• Analysis of serine-threonine kinase specificity using arrayed positional scanning peptide libraries.Chen C, Turk BE. Curr Protoc Mol Biol. 2010 Jul. PMID: 20583094.
• MOTIPS: automated motif analysis for predicting targets of modular protein domains.Lam HY, Kim PM, Mok J, Tonikian R, Sidhu SS, Turk BE, Snyder M, Gerstein MB. BMC Bioinformatics. 2010 May 11; 2010 May 11. PMID: 20459839.
• Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. PLoS One. 2010 May 7; 2010 May 7. PMID: 20498699.
• Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs.Mok J, Kim PM, Lam HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M, Turk BE. Sci Signal. 2010 Feb 16; 2010 Feb 16. PMID: 20159853.
• Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10.Caescu CI, Jeschke GR, Turk BE. Biochem J. 2009 Oct 23; 2009 Oct 23. PMID: 19715556.
• Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases.Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. FEBS J. 2009 Aug. PMID: 19678838.
• Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Structure. 2009 Mar 11. PMID: 19278650.
• Structural insights into the inhibited states of the Mer receptor tyrosine kinase.Huang X, Finerty P Jr, Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S. J Struct Biol. 2009 Feb; 2008 Nov 5. PMID: 19028587.
• Mixture-based peptide libraries for identifying protease cleavage motifs.Turk BE. Methods Mol Biol. 2009. PMID: 19377969.
• Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.Filippakopoulos P, Kofler M, Hantschel O, Gish GD, Grebien F, Salah E, Neudecker P, Kay LE, Turk BE, Superti-Furga G, Pawson T, Knapp S. Cell. 2008 Sep 5. PMID: 18775312.
• Linear motif atlas for phosphorylation-dependent signaling.Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R. Sci Signal. 2008 Sep 2; 2008 Sep 2. PMID: 18765831.
• Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs.Sheridan DL, Kong Y, Parker SA, Dalby KN, Turk BE. J Biol Chem. 2008 Jul 11; 2008 May 15. PMID: 18482985.
• A versatile strategy to define the phosphorylation preferences of plant protein kinases and screen for putative substrates.Vlad F, Turk BE, Peynot P, Leung J, Merlot S. Plant J. 2008 Jul. PMID: 18363786.
• AMPK phosphorylation of raptor mediates a metabolic checkpoint.Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. Mol Cell. 2008 Apr 25. PMID: 18439900.
• Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.Pike AC, Rellos P, Niesen FH, Turnbull A, Oliver AW, Parker SA, Turk BE, Pearl LH, Knapp S. EMBO J. 2008 Feb 20; 2008 Jan 31. PMID: 18239682.
• Discovery and development of anthrax lethal factor metalloproteinase inhibitors.Turk BE. Curr Pharm Biotechnol. 2008 Feb. PMID: 18289054.
• Understanding and exploiting substrate recognition by protein kinases.Turk BE. Curr Opin Chem Biol. 2008 Feb; 2008 Mar 7. PMID: 18282484.