Yuka Takeo, PhD, DVM
Associate Research Scientist in GeneticsCards
About
Research
Publications
2025
The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection
Woo T, Takeo Y, Harwood M, Houck E, DiMaio D, Tsai B. The nuclear import receptor importin-7 targets HPV from the Golgi to the nucleus to promote infection. Science Advances 2025, 11: eadz6792. PMID: 41124246, PMCID: PMC12542944, DOI: 10.1126/sciadv.adz6792.Peer-Reviewed Original ResearchConceptsC-terminal nuclear localization sequenceimportin 7nuclear envelope breakdownnuclear entrycell-penetrating peptide sequencetrafficking stepsimport machineryimport receptormitotic nuclear envelope breakdownGolgi apparatusmitotic chromosomesGolgicellular cargoenvelope breakdownpeptide sequencesL2 proteinhuman papillomavirus infectionhuman papillomavirusretrograde transportimportinchromosomeinfectionknockdownnucleusproteinγ-secretase facilitates retromer-mediated retrograde transport
Takeo Y, Crite M, Mehmood K, DiMaio D. γ-secretase facilitates retromer-mediated retrograde transport. Journal Of Cell Science 2025, 138: jcs263538. PMID: 39865938, PMCID: PMC11883284, DOI: 10.1242/jcs.263538.Peer-Reviewed Original ResearchConceptstrans-Golgi networktransport of protein cargoretrograde protein traffickingcation-independent mannose-6-phosphate receptorcellular transmembrane proteinsmannose-6-phosphate receptorassociation with cargohuman epithelial cellsbinds retromerretromer subunitsretromer cargoRab7-GTPShiga toxinretrograde transportcultured human epithelial cellsprotein traffickingretromercatalytic subunittransmembrane domaintransmembrane proteinsprotein cargocellular cargotarget proteinsfunctional consequencescholera toxin
2023
HPV is a cargo for the COPI sorting complex during virus entry
Harwood M, Woo T, Takeo Y, DiMaio D, Tsai B. HPV is a cargo for the COPI sorting complex during virus entry. Science Advances 2023, 9: eadc9830. PMID: 36662862, PMCID: PMC9858521, DOI: 10.1126/sciadv.adc9830.Peer-Reviewed Original ResearchConceptscoat protein complex Itrans-Golgi networkprotein complex Igene knockdown strategyvirus entryCOPI complexprotein complexescellular fractionationunbiased proteomicsretrograde traffickingcytoplasmic segmentGolgi stackscellular cargoL2 mutantknockdown strategyGolgi apparatuscomplex Iincoming viruscell surfaceGolgihost factorscargocomplexesmutantsendosomes
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