Nachshon Korem
Associate Research Scientist in PsychiatryCards
About
Research
Publications
2026
A Continuum Is Not a Hammer: Response to Lowell and Markowitz (2026) on the Exposure Continuum Model
Rubinstein D, Korem N, Bullard D, Harpaz-Rotem I. A Continuum Is Not a Hammer: Response to Lowell and Markowitz (2026) on the Exposure Continuum Model. Journal Of Anxiety Disorders 2026, 103200. PMID: 42297653, DOI: 10.1016/j.janxdis.2026.103200.Peer-Reviewed Original ResearchImproving PTSD Treatment With Ketamine-Augmented Exposure Therapy: A Double-Blind Randomized Clinical Trial
Harpaz-Rotem I, Abargail M, Duek O, Korem N, Rubinstein D, Keynan N, Harari A, Eizenbach T, Kang M, Koryto Y, Sharon H, Nia A, Krystal J, Hendler T. Improving PTSD Treatment With Ketamine-Augmented Exposure Therapy: A Double-Blind Randomized Clinical Trial. Biological Psychiatry 2026, 99: s45. DOI: 10.1016/j.biopsych.2026.03.114.Peer-Reviewed Original Research612. Childhood Maltreatment is Associated With Blunted Hippocampal Offline Reinstatement After Idiosyncratic Trauma Recall in PTSD
Qu Y, Basol E, Paterson M, Davydovska T, Samonek K, Ben-Zion Z, Korem N, Cocuzza C, Joormann J, Harpaz-Rotem I. 612. Childhood Maltreatment is Associated With Blunted Hippocampal Offline Reinstatement After Idiosyncratic Trauma Recall in PTSD. Biological Psychiatry 2026, 99: s361-s362. DOI: 10.1016/j.biopsych.2026.03.846.Peer-Reviewed Original Research241. Neural Circuitry of “Hotspots” During Free Trauma Recollection in PTSD
Rubinstein D, Korem N, Duek O, Abargail M, Basol E, Davydovska T, Gordon C, O'Brien E, Metviner S, Harpaz-Rotem I, Basol E. 241. Neural Circuitry of “Hotspots” During Free Trauma Recollection in PTSD. Biological Psychiatry 2026, 99: s202. DOI: 10.1016/j.biopsych.2026.03.475.Peer-Reviewed Original Research
2025
The exposure continuum model: A theoretical framework for understanding exposure across trauma-centered psychotherapies
Rubinstein D, Korem N, Bullard D, Harpaz-Rotem I. The exposure continuum model: A theoretical framework for understanding exposure across trauma-centered psychotherapies. Journal Of Anxiety Disorders 2025, 117: 103107. PMID: 41371190, DOI: 10.1016/j.janxdis.2025.103107.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTrauma-focused therapyExposure therapyNeurobiological mechanismsTrauma typesIndividual differencesSymptom severityTrauma treatmentExposure componentPsychotherapyTherapeutic settingData-driven explorationTreatment approachesExposure techniqueTherapistsTraumaSymptomsTheoretical frameworkExposureTheoretical paperTherapeutic approachesCliniciansTherapySeverityTreatmentDimensionsCannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Korem N, Bassir Nia A, Hillmer A, D’Souza D, Nabulsi N, Ropchan J, Huang Y, Cosgrove K, Levy I, Pietrzak R, Harpaz-Rotem I. Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study. Translational Psychiatry 2025, 15: 310. PMID: 40846835, PMCID: PMC12373994, DOI: 10.1038/s41398-025-03519-9.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderEmotional numbing symptomsCB1R availabilityPosttraumatic stress disorderEndocannabinoid systemStress disorderPositron emission tomographyTrauma-exposed participantsEndocannabinoid system's rolePositron emission tomography studiesCannabinoid receptor 1Emission tomography studiesMulti-faceted disorderFear learningCB1RSymptom expressionHealthy controlsCannabinoidDisordersTomography studiesEmission tomographyPreclinical studiesSymptomsHigher levelsReceptor 1Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkModeling decision-making under uncertainty with qualitative outcomes
Korem N, Duek O, Jia R, Wertheimer E, Metviner S, Grubb M, Levy I. Modeling decision-making under uncertainty with qualitative outcomes. PLOS Computational Biology 2025, 21: e1012440. PMID: 40029903, PMCID: PMC11918403, DOI: 10.1371/journal.pcbi.1012440.Peer-Reviewed Original Research
2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchPost-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT
Korem N, Duek O, Ben-Zion Z, Spiller T, Gordon C, Amen S, Levy I, Harpaz-Rotem I. Post-treatment alterations in white matter integrity in PTSD: Effects on symptoms and functional connectivity a secondary analysis of an RCT. Psychiatry Research Neuroimaging 2024, 343: 111864. PMID: 39111111, DOI: 10.1016/j.pscychresns.2024.111864.Peer-Reviewed Original ResearchReduced resting-state functional connectivityPost-traumatic stress disorderPost-traumatic stress disorder symptomsFunctional connectivityPost-treatment changesReducing PTSD symptom severityFollow-up changesResting-state functional connectivityIntensive exposure therapyExposure-based psychotherapyVentromedial prefrontal cortexPTSD symptom severityReduced structural connectivityFunctional connectivity patternsPost-treatmentWhite matter integrityPrefrontal cortexExposure therapyPTSD symptomsStress disorderSymptom severityUncinate fasciculusLimbic systemSecondary analysisAssociated with sustained changes
News
News
- April 08, 2025
How Does Your Brain Make Decisions? Researchers Develop a Novel Model
- September 09, 2024Source: Yale News
Endocannabinoids Are Associated With Emotional Numbing in PTSD
- May 03, 2024Source: Yale News
Rapid Emotion Transitions May Explain Numbness and Hyperreactivity in PTSD
- January 02, 2024
Duek, Harpaz-Rotem Paper Named '2023 Leading Research Achievement' by BBRF
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