ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures
Yang Y, Kumar H, Xie Y, Li Z, Li R, Chen W, Diala C, Ali M, Xu Y, Wu A, Hosseini S, Bi E, Zhao H, Kim P, Zheng W. ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures. Nucleic Acids Research 2024, 53: d331-d339. PMID: 39530217, PMCID: PMC11701669, DOI: 10.1093/nar/gkae1018.Peer-Reviewed Original ResearchConceptsHuman protein isoformsAlternative splicingProtein isoformsGeneration of multiple protein isoformsImpact of alternative splicingMultiple protein isoformsProtein-protein interactionsFunctional annotationCanonical isoformSplicing eventsSequence variationIntegrated knowledgebaseCellular processesProtein structureSplicingStructural biologyHuman diseasesDiverse functionsIsoformsDisease mechanismsStructural alterationsEukaryotesComprehensive databaseProteinSequence
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