Publications

• Cholesterol promotes IFNG mRNA expression in CD4(+) effector/memory cells by SGK1 activation.Hanin A, Comi M, Sumida TS, Hafler DA. Life Sci Alliance. 2024 Dec; 2024 Oct 4. PMID: 39366761.
• Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.Zhao AY, Unterman A, Abu Hussein NS, Sharma P, Nikola F, Flint J, Yan X, Adams TS, Justet A, Sumida TS, Zhao J, Schupp JC, Raredon MSB, Ahangari F, Deluliis G, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling AI, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Am J Respir Crit Care Med. 2024 Nov 15. PMID: 38924775.
• A scalable approach to topic modelling in single-cell data by approximate pseudobulk projection.Subedi S, Sumida TS, Park YP. Life Sci Alliance. 2024 Oct; 2024 Aug 6. PMID: 39107066.
• A Nerve-Fibroblast Axis in Mammalian Lung Fibrosis.Ishikawa G, Peng X, McGovern J, Ghincea A, Woo S, Okuno D, Yu S, Lee CJ, Liu A, Saber T, Hu B, Sun Y, Sun H, Jumaily KA, Feghali-Bostwick C, Sumida TS, Sauler M, Ryu C, Herzog EL. bioRxiv. 2024 Sep 9; 2024 Sep 9. PMID: 39314391.
• An autoimmune transcriptional circuit drives FOXP3(+) regulatory T cell dysfunction.Sumida TS, Lincoln MR, He L, Park Y, Ota M, Oguchi A, Son R, Yi A, Stillwell HA, Leissa GA, Fujio K, Murakawa Y, Kulminski AM, Epstein CB, Bernstein BE, Kellis M, Hafler DA. Sci Transl Med. 2024 Aug 28; 2024 Aug 28. PMID: 39196959.
• Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya JD, Dela Cruz CS, Herzog EL, Kaminski N. Am J Respir Crit Care Med. 2024 Aug 15. PMID: 38717443.
• The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases.Sumida TS, Cheru NT, Hafler DA. Nat Rev Immunol. 2024 Jul; 2024 Feb 19. PMID: 38374298.
• Systems Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis.Wei J, Moon J, Yasumizu Y, Zhang L, Radassi K, Buitrago-Pocasangre N, Deerhake ME, Strauli N, Chan A, Herman A, Pedotte R, Raposo C, Tackenberg B, Yim I, Pappalardo J, Longbrake EE, Sumida TS, Axisa PP, Hafler DA. bioRxiv. 2024 Feb 9; 2024 Feb 9. PMID: 38370778.
• Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung Diseases.Zhao AY, Unterman A, Abu Hussein N, Sharma P, Flint J, Yan X, Adams TS, Justet A, Sumida TS, Zhao J, Schupp JC, Raredon MSB, Ahangari F, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling AI, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. bioRxiv. 2023 Sep 22; 2023 Sep 22. PMID: 37786685.
• Latent EBV impairs immune cell signaling and enhances the efficacy of anti-CD3 mAb in Type 1 Diabetes.Delgado AL, Preston-Hurlburt P, Lim N, Sumida TS, Long SA, McNamara J, Serti E, Higdon L, Herold KC. medRxiv. 2023 Jul 13; 2023 Jul 13. PMID: 37502867.
• Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.Barmada A, Klein J, Ramaswamy A, Brodsky NN, Jaycox JR, Sheikha H, Jones KM, Habet V, Campbell M, Sumida TS, Kontorovich A, Bogunovic D, Oliveira CR, Steele J, Hall EK, Pena-Hernandez M, Monteiro V, Lucas C, Ring AM, Omer SB, Iwasaki A, Yildirim I, Lucas CL. Sci Immunol. 2023 May 12; 2023 May 5. PMID: 37146127.
• Regulatory T cells in peripheral tissue tolerance and diseases.Cheru N, Hafler DA, Sumida TS. Front Immunol. 2023; 2023 May 1. PMID: 37197653.
• Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis.Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya J, Dela Cruz CS, Herzog EL, Kaminski N. medRxiv. 2023 Apr 29; 2023 Apr 29. PMID: 37163015.
• Hyperosmotic stress response regulates interstitial homeostasis and pathogenic inflammation.Sumida TS. J Biochem. 2023 Mar 7. PMID: 36722164.
• PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infection.Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein SH, Montgomery RR, Iwasaki A, Dela Cruz CS, Kaminski N, Shaw AC, Hafler DA, Sumida TS. Cell Rep. 2023 Jan 31; 2023 Jan 2. PMID: 36596303.
• A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.Axisa PP, Yoshida TM, Lucca LE, Kasler HG, Lincoln MR, Pham GH, Del Priore D, Carpier JM, Lucas CL, Verdin E, Sumida TS, Hafler DA. Sci Transl Med. 2022 Dec 14; 2022 Dec 14. PMID: 36516268.
• Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis.Asashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. J Clin Invest. 2022 Oct 17; 2022 Oct 17. PMID: 36250467.
• Identity thieves: T cells steal CD20 from B cells but mark themselves for certain death.Sumida TS, O'Connor KC. Sci Immunol. 2022 May 6; 2022 May 6. PMID: 35522724.
• Population genetics meets single-cell sequencing.Sumida TS, Hafler DA. Science. 2022 Apr 8; 2022 Apr 7. PMID: 35389792.
• Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Nat Immunol. 2022 Apr; 2022 Mar 17. PMID: 35301508.
• Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.
• Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes.Rui J, Deng S, Perdigoto AL, Ponath G, Kursawe R, Lawlor N, Sumida T, Levine-Ritterman M, Stitzel ML, Pitt D, Lu J, Herold KC. Nat Commun. 2021 Aug 20; 2021 Aug 20. PMID: 34417463.
• Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. J Immunol. 2021 Jun 15; 2021 May 28. PMID: 34049971.
• Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Res Sq. 2021 Jun 8; 2021 Jun 8. PMID: 34127967.
• NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data.He L, Davila-Velderrain J, Sumida TS, Hafler DA, Kellis M, Kulminski AM. Commun Biol. 2021 May 26; 2021 May 26. PMID: 34040149.
• Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immunity. 2021 May 11; 2021 Apr 13. PMID: 33891889.
• Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. medRxiv. 2021 Apr 3; 2021 Apr 3. PMID: 33300011.
• Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. bioRxiv. 2020 Oct 31; 2020 Oct 31. PMID: 33140047.
• Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.Yamaguchi T, Sumida TS, Nomura S, Satoh M, Higo T, Ito M, Ko T, Fujita K, Sweet ME, Sanbe A, Yoshimi K, Manabe I, Sasaoka T, Taylor MRG, Toko H, Takimoto E, Naito AT, Komuro I. Nat Commun. 2020 Aug 31; 2020 Aug 31. PMID: 32868781.
• Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction.Shibamoto M, Higo T, Naito AT, Nakagawa A, Sumida T, Okada K, Sakai T, Kuramoto Y, Yamaguchi T, Ito M, Masumura Y, Higo S, Lee JK, Hikoso S, Komuro I, Sakata Y. Int Heart J. 2019 Jul 27; 2019 Jun 28. PMID: 31257341.
• Author Correction: Activated β-catenin in Foxp3(+) regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Nat Immunol. 2019 Jul. PMID: 31175348.
• Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Nat Microbiol. 2019 Jun; 2019 Mar 11. PMID: 30858571.
• High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload.Satoh M, Nomura S, Harada M, Yamaguchi T, Ko T, Sumida T, Toko H, Naito AT, Takeda N, Tobita T, Fujita T, Ito M, Fujita K, Ishizuka M, Kariya T, Akazawa H, Kobayashi Y, Morita H, Takimoto E, Aburatani H, Komuro I. J Mol Cell Cardiol. 2019 Mar; 2019 Jan 3. PMID: 30611794.
• Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Nat Commun. 2018 Dec 17; 2018 Dec 17. PMID: 30559390.
• Activated β-catenin in Foxp3(+) regulatory T cells links inflammatory environments to autoimmunity.Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Nat Immunol. 2018 Dec; 2018 Oct 29. PMID: 30374130.
• Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I. Nat Commun. 2018 Oct 30; 2018 Oct 30. PMID: 30375404.
• Author Correction: Activation of endothelial β-catenin signaling induces heart failure.Nakagawa A, Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I. Sci Rep. 2018 Oct 29; 2018 Oct 29. PMID: 30374020.
• Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy.Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I. Int Heart J. 2018 Sep 26; 2018 Aug 11. PMID: 30101858.
• DNA single-strand break-induced DNA damage response causes heart failure.Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I. Nat Commun. 2017 Apr 24; 2017 Apr 24. PMID: 28436431.
• Activation of endothelial β-catenin signaling induces heart failure.Nakagawa A, Naito AT, Sumida T, Nomura S, Shibamoto M, Higo T, Okada K, Sakai T, Hashimoto A, Kuramoto Y, Oka T, Lee JK, Harada M, Ueda K, Shiojima I, Limbourg FP, Adams RH, Noda T, Sakata Y, Akazawa H, Komuro I. Sci Rep. 2016 May 5; 2016 May 5. PMID: 27146149.
• Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes.Hashimoto A, Naito AT, Lee JK, Kitazume-Taneike R, Ito M, Yamaguchi T, Nakata R, Sumida T, Okada K, Nakagawa A, Higo T, Kuramoto Y, Sakai T, Tominaga K, Okinaga T, Kogaki S, Ozono K, Miyagawa S, Sawa Y, Sakata Y, Morita H, Umezawa A, Komuro I. Int Heart J. 2016; 2015 Dec 17. PMID: 26673445.
• Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression.Yabumoto C, Akazawa H, Yamamoto R, Yano M, Kudo-Sakamoto Y, Sumida T, Kamo T, Yagi H, Shimizu Y, Saga-Kamo A, Naito AT, Oka T, Lee JK, Suzuki J, Sakata Y, Uejima E, Komuro I. Sci Rep. 2015 Sep 25; 2015 Sep 25. PMID: 26571361.
• A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling.Nakayama A, Morita H, Nakao T, Yamaguchi T, Sumida T, Ikeda Y, Kumagai H, Motozawa Y, Takahashi T, Imaizumi A, Hashimoto T, Nagai R, Komuro I. PLoS One. 2015; 2015 Sep 1. PMID: 26327560.
• Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.Okada K, Naito AT, Higo T, Nakagawa A, Shibamoto M, Sakai T, Hashimoto A, Kuramoto Y, Sumida T, Nomura S, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Morimoto S, Sakata Y, Shiojima I, Komuro I. Circ Heart Fail. 2015 Jul; 2015 Jun 2. PMID: 26038536.
• Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I. Nat Commun. 2015 Feb 26; 2015 Feb 26. PMID: 25716000.
• Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Cell. 2012 Jun 8. PMID: 22682250.
• Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury.Naito AT, Okada S, Minamino T, Iwanaga K, Liu ML, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I. Circ Res. 2010 Jun 11; 2010 Apr 22. PMID: 20413784.