Publications

• Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter SM, Lake EMR. J Neurotrauma. 2024 Dec; 2024 Sep 20. PMID: 39096127.
• CosGeneGate selects multi-functional and credible biomarkers for single-cell analysis.Liu T, Long W, Cao Z, Wang Y, He CH, Zhang L, Strittmatter SM, Zhao H. Brief Bioinform. 2024 Nov 22. PMID: 39592241.
• Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Mandino F, Shen X, Desrosiers-Grégoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EMR. Mol Psychiatry. 2024 Oct 18; 2024 Oct 18. PMID: 39424929.
• Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.Liu Y, Tuttle MD, Kostylev MA, Roseman GP, Zilm KW, Strittmatter SM. J Am Chem Soc. 2024 Oct 9; 2024 Sep 26. PMID: 39326869.
• Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.Takahashi H, Perez-Canamas A, Lee CW, Ye H, Han X, Strittmatter SM. Commun Biol. 2024 Sep 5; 2024 Sep 5. PMID: 39237682.
• Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity.Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter SM, Lake E. bioRxiv. 2024 May 26; 2024 May 26. PMID: 38826468.
• Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.Takahashi H, Bhagwagar S, Nies SH, Ye H, Han X, Chiasseu MT, Wang G, Mackenzie IR, Strittmatter SM. Nat Commun. 2024 Feb 16; 2024 Feb 16. PMID: 38365772.
• Aging-Dependent Loss of Connectivity in Alzheimer's Model Mice with Rescue by mGluR5 Modulator.Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EM. bioRxiv. 2024 Jan 8; 2024 Jan 8. PMID: 38260465.
• Development of neural repair therapy for chronic spinal cord trauma: soluble Nogo receptor decoy from discovery to clinical trial.Howard EM, Strittmatter SM. Curr Opin Neurol. 2023 Dec 1; 2023 Sep 19. PMID: 37865850.
• Neuronal transcriptome, tau and synapse loss in Alzheimer's knock-in mice require prion protein.Stoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter SM. Alzheimers Res Ther. 2023 Nov 15; 2023 Nov 15. PMID: 37968719.
• Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration.Sekine Y, Wang X, Kikkawa K, Honda S, Strittmatter SM. J Biol Chem. 2023 Oct; 2023 Sep 9. PMID: 37690690.
• Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.Takahashi H, Perez-Canamas A, Ye H, Han X, Strittmatter SM. bioRxiv. 2023 Sep 14; 2023 Sep 14. PMID: 37745346.
• Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial.Maynard G, Kannan R, Liu J, Wang W, Lam TKT, Wang X, Adamson C, Hackett C, Schwab JM, Liu C, Leslie DP, Chen D, Marino R, Zafonte R, Flanders A, Block G, Smith E, Strittmatter SM. Lancet Neurol. 2023 Aug. PMID: 37479373.
• Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. medRxiv. 2023 Jul 8; 2023 Jul 8. PMID: 37461624.
• TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury.Shafit-Zagardo B, Sidoli S, Goldman JE, DuBois JC, Corboy JR, Strittmatter SM, Guzik H, Edema U, Arackal AG, Botbol YM, Merheb E, Nagra RM, Graff S. Cells. 2023 Jun 27; 2023 Jun 27. PMID: 37443768.
• Nogo receptor-Fc delivered by haematopoietic cells enhances neurorepair in a multiple sclerosis model.Ye S, Theotokis P, Lee JY, Kim MJ, Nheu D, Ellen O, Bedford T, Ramanujam P, Wright DK, McDonald SJ, Alrehaili A, Bakhuraysah M, Kang JH, Siatskas C, Tremblay CS, Curtis DJ, Grigoriadis N, Monif M, Strittmatter SM, Petratos S. Brain Commun. 2023; 2023 Apr 4. PMID: 37091588.
• Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
• Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [(18)F]SDM-16.Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter SM, Carson RE, Huang Y, Cai Z. Front Neurol. 2023; 2023 Feb 8. PMID: 36846134.
• Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.de Arce KP, Ribic A, Chowdhury D, Watters K, Thompson GJ, Sanganahalli BG, Lippard ETC, Rohlmann A, Strittmatter SM, Missler M, Hyder F, Biederer T. Nat Commun. 2023 Jan 28; 2023 Jan 28. PMID: 36709330.
• Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD. Cell Rep. 2022 Oct 25. PMID: 36288715.
• Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Science. 2022 Sep 30; 2022 Sep 30. PMID: 36007006.
• IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.Clement M, Forbester JL, Marsden M, Sabberwal P, Sommerville MS, Wellington D, Dimonte S, Clare S, Harcourt K, Yin Z, Nobre L, Antrobus R, Jin B, Chen M, Makvandi-Nejad S, Lindborg JA, Strittmatter SM, Weekes MP, Stanton RJ, Dong T, Humphreys IR. Nat Commun. 2022 Sep 8; 2022 Sep 8. PMID: 36075894.
• Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM. Mol Neurodegener. 2022 Aug 30; 2022 Aug 30. PMID: 36038879.
• Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [(11)C]AFM.Fang H, Rossano S, Wang X, Nabulsi N, Kelley B, Fowles K, Ropchan J, Strittmatter SM, Carson RE, Huang Y. Mol Imaging Biol. 2022 Aug; 2022 Jan 12. PMID: 35020138.
• Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma.Sekine Y, Kannan R, Wang X, Strittmatter SM. Exp Neurol. 2022 Jul; 2022 Apr 7. PMID: 35398339.
• Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Sci Transl Med. 2022 Jun; 2022 Jun 1. PMID: 35648810.
• Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM. Mol Neurodegener. 2022 May 3; 2022 May 3. PMID: 35501917.
• An unexpected protein aggregate in diseased and ageing brains.Takahashi H, Strittmatter SM. Nature. 2022 May. PMID: 35379977.
• Multimodal imaging of synaptic vesicles with a single probe.An SJ, Stagi M, Gould TJ, Wu Y, Mlodzianoski M, Rivera-Molina F, Toomre D, Strittmatter SM, De Camilli P, Bewersdorf J, Zenisek D. Cell Rep Methods. 2022 Apr 25; 2022 Apr 25. PMID: 35497490.
• PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging.Toyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. Front Neurosci. 2022; 2022 Mar 8. PMID: 35345546.
• Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells.Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Neuron. 2022 Feb 2; 2021 Nov 18. PMID: 34798047.
• NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates.Boghdadi AG, Spurrier J, Teo L, Li M, Skarica M, Cao B, Kwan WC, Merson TD, Nilsson SK, Sestan N, Strittmatter SM, Bourne JA. Nat Commun. 2021 Nov 25; 2021 Nov 25. PMID: 34824275.
• Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM. J Biol Chem. 2021 Oct; 2021 Sep 2. PMID: 34480901.
• Quantification of SV2A Binding in Rodent Brain Using [(18)F]SynVesT-1 and PET Imaging.Sadasivam P, Fang XT, Toyonaga T, Lee S, Xu Y, Zheng MQ, Spurrier J, Huang Y, Strittmatter SM, Carson RE, Cai Z. Mol Imaging Biol. 2021 Jun; 2020 Nov 30. PMID: 33258040.
• Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Cell Rep. 2021 Mar 2. PMID: 33657370.
• B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF.Bakhuraysah MM, Theotokis P, Lee JY, Alrehaili AA, Aui PM, Figgett WA, Azari MF, Abou-Afech JP, Mackay F, Siatskas C, Alderuccio F, Strittmatter SM, Grigoriadis N, Petratos S. Sci Rep. 2021 Feb 3; 2021 Feb 3. PMID: 33536561.
• Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders.Perez-Canamas A, Takahashi H, Lindborg JA, Strittmatter SM. Brain Commun. 2021; 2020 Nov 16. PMID: 33796852.
• Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. JAMA Neurol. 2021 Jan 1. PMID: 33074286.
• Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Neurobiol Dis. 2020 Nov; 2020 Aug 25. PMID: 32858147.
• Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM. Acta Neuropathol Commun. 2020 Jul 1; 2020 Jul 1. PMID: 32611392.
• Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury.Wang X, Zhou T, Maynard GD, Terse PS, Cafferty WB, Kocsis JD, Strittmatter SM. Brain. 2020 Jun 1. PMID: 32375169.
• A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration.Sekine Y, Lindborg JA, Strittmatter SM. J Biol Chem. 2020 Feb 21; 2019 Nov 20. PMID: 31748413.
• The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M. J Cell Biol. 2020 Feb 3. PMID: 31968056.
• PET imaging of mGluR5 in Alzheimer's disease.Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. Alzheimers Res Ther. 2020 Jan 18; 2020 Jan 18. PMID: 31954399.
• In Vivo Synaptic Density Imaging with (11)C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease.Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. J Nucl Med. 2019 Dec; 2019 May 17. PMID: 31101744.
• Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. JAMA Neurol. 2019 Oct 1. PMID: 31329216.
• Whole-Exome Sequencing of an Exceptional Longevity Cohort.Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer MJ, Vilariño-Güell C, Strittmatter SM. J Gerontol A Biol Sci Med Sci. 2019 Aug 16. PMID: 29750252.
• Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.Lee JY, Kim MJ, Thomas S, Oorschot V, Ramm G, Aui PM, Sekine Y, Deliyanti D, Wilkinson-Berka J, Niego B, Harvey AR, Theotokis P, McLean C, Strittmatter SM, Petratos S. J Neurosci. 2019 Jul 10; 2019 May 6. PMID: 31061088.
• Diltiazem Promotes Regenerative Axon Growth.Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Mol Neurobiol. 2019 Jun; 2018 Sep 19. PMID: 30232777.
• Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM. J Neurosci. 2019 Apr 24; 2019 Feb 25. PMID: 30804090.
• Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.Smith LM, Kostylev MA, Lee S, Strittmatter SM. J Biol Chem. 2019 Apr 12; 2019 Feb 20. PMID: 30787106.
• Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.Lee S, Salazar SV, Cox TO, Strittmatter SM. J Neurosci. 2019 Mar 6; 2019 Jan 9. PMID: 30626696.
• Anti-PrP(C) antibody rescues cognition and synapses in transgenic alzheimer mice.Cox TO, Gunther EC, Brody AH, Chiasseu MT, Stoner A, Smith LM, Haas LT, Hammersley J, Rees G, Dosanjh B, Groves M, Gardener M, Dobson C, Vaughan T, Chessell I, Billinton A, Strittmatter SM. Ann Clin Transl Neurol. 2019 Mar; 2019 Feb 27. PMID: 30911579.
• Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM. Cell Rep. 2019 Jan 29. PMID: 30699361.
• Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM. J Neurosci. 2019 Jan 23; 2018 Dec 5. PMID: 30518596.
• Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM. Cell Rep. 2019 Jan 2. PMID: 30605671.
• Liquid and Hydrogel Phases of PrP(C) Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM. Mol Cell. 2018 Nov 1; 2018 Oct 25. PMID: 30401430.
• Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.Dell'Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM. Nat Commun. 2018 Aug 24; 2018 Aug 24. PMID: 30143638.
• Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Cell Rep. 2018 Jul 3. PMID: 29972787.
• Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Cell Rep. 2018 Apr 10. PMID: 29642001.
• The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM. Sci Signal. 2018 Apr 3; 2018 Apr 3. PMID: 29615517.
• Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.Smith LM, Zhu R, Strittmatter SM. Neuropharmacology. 2018 Mar 1; 2017 Nov 27. PMID: 29191754.
• Emerging Mechanisms in Alzheimer's Disease and Their Therapeutic Implications.Strittmatter SM. Biol Psychiatry. 2018 Feb 15. PMID: 29331211.
• Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.Kent BA, Strittmatter SM, Nygaard HB. J Alzheimers Dis. 2018. PMID: 29991134.
• Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.Brody AH, Strittmatter SM. Adv Pharmacol. 2018; 2017 Oct 25. PMID: 29413525.
• Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K. Sci Rep. 2017 Sep 21; 2017 Sep 21. PMID: 28935984.
• Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.Salazar SV, Gallardo C, Kaufman AC, Herber CS, Haas LT, Robinson S, Manson JC, Lee MK, Strittmatter SM. J Neurosci. 2017 Sep 20; 2017 Aug 21. PMID: 28842420.
• Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM. J Neurosci. 2017 Jul 26; 2017 Jun 21. PMID: 28637841.
• Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM. Neuron. 2017 Jul 19. PMID: 28728022.
• Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM. Cell Rep. 2017 Jul 5. PMID: 28683325.
• Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease.Heiss JK, Barrett J, Yu Z, Haas LT, Kostylev MA, Strittmatter SM. Cereb Cortex. 2017 Jul 1. PMID: 27365298.
• Rewiring the spinal cord: Direct and indirect strategies.Dell'Anno MT, Strittmatter SM. Neurosci Lett. 2017 Jun 23; 2016 Dec 19. PMID: 28007647.
• Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Acta Neuropathol. 2017 May; 2017 Jan 9. PMID: 28070672.
• Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.Smith LM, Strittmatter SM. Cold Spring Harb Perspect Med. 2017 May 1; 2017 May 1. PMID: 27940601.
• Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ. Cell Rep. 2017 Mar 14. PMID: 28297672.
• Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease.Salazar SV, Strittmatter SM. Biochem Biophys Res Commun. 2017 Feb 19; 2016 Sep 14. PMID: 27639648.
• Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.Wang X, Sekine Y, Byrne AB, Cafferty WB, Hammarlund M, Strittmatter SM. eNeuro. 2016 Nov-Dec; 2016 Dec 26. PMID: 28032120.
• Axonal branching in lateral olfactory tract is promoted by Nogo signaling.Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K. Sci Rep. 2016 Dec 21; 2016 Dec 21. PMID: 28000762.
• Inhibiting poly(ADP-ribosylation) improves axon regeneration.Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Elife. 2016 Oct 4; 2016 Oct 4. PMID: 27697151.
• Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles.Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J. Nanomedicine. 2016 Oct; 2016 Mar 30. PMID: 27039220.
• Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284.
• Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood.Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM. Mol Psychiatry. 2016 Sep; 2015 Dec 1. PMID: 26619810.
• Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.Haas LT, Strittmatter SM. J Biol Chem. 2016 Aug 12; 2016 Jun 20. PMID: 27325698.
• SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM. BMJ Open. 2016 Jul 26; 2016 Jul 26. PMID: 27466236.
• Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM. Brain. 2016 Feb; 2015 Dec 14. PMID: 26667279.
• Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice.Fink KL, Strittmatter SM, Cafferty WB. J Neurosci. 2015 Nov 18. PMID: 26586827.
• Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM. J Neurosci. 2015 Jul 22. PMID: 26203138.
• Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM. J Biol Chem. 2015 Jul 10; 2015 May 27. PMID: 26018073.
• Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM. Ann Neurol. 2015 Jun; 2015 Mar 21. PMID: 25707991.
• Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.Nygaard HB, Kaufman AC, Sekine-Konno T, Huh LL, Going H, Feldman SJ, Kostylev MA, Strittmatter SM. Alzheimers Res Ther. 2015; 2015 May 5. PMID: 25945128.
• A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH. Alzheimers Res Ther. 2015; 2015 Apr 14. PMID: 25874001.
• Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.Nakatsu F, Messa M, Nández R, Czapla H, Zou Y, Strittmatter SM, De Camilli P. J Cell Biol. 2015 Apr 13. PMID: 25869668.
• Intravitreal delivery of human NgR-Fc decoy protein regenerates axons after optic nerve crush and protects ganglion cells in glaucoma models.Wang X, Lin J, Arzeno A, Choi JY, Boccio J, Frieden E, Bhargava A, Maynard G, Tsai JC, Strittmatter SM. Invest Ophthalmol Vis Sci. 2015 Feb 5; 2015 Feb 5. PMID: 25655801.
• Plasticity of intact rubral projections mediates spontaneous recovery of function after corticospinal tract injury.Siegel CS, Fink KL, Strittmatter SM, Cafferty WB. J Neurosci. 2015 Jan 28. PMID: 25632122.
• Human NgR-Fc decoy protein via lumbar intrathecal bolus administration enhances recovery from rat spinal cord contusion.Wang X, Yigitkanli K, Kim CY, Sekine-Komo T, Wirak D, Frieden E, Bhargava A, Maynard G, Cafferty WB, Strittmatter SM. J Neurotrauma. 2014 Dec 15; 2014 Oct 16. PMID: 24964223.
• Progressive retinal degeneration and accumulation of autofluorescent lipopigments in Progranulin deficient mice.Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM. Brain Res. 2014 Nov 7; 2014 Sep 16. PMID: 25234724.
• Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Haas LT, Kostylev MA, Strittmatter SM. J Biol Chem. 2014 Oct 10; 2014 Aug 22. PMID: 25148681.
• Diffusion tensor imaging as a predictor of locomotor function after experimental spinal cord injury and recovery.Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM. J Neurotrauma. 2014 Aug 1; 2014 Jul 8. PMID: 24779685.
• Nogo limits neural plasticity and recovery from injury.Schwab ME, Strittmatter SM. Curr Opin Neurobiol. 2014 Aug; 2014 Mar 12. PMID: 24632308.
• Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.Stagi M, Klein ZA, Gould TJ, Bewersdorf J, Strittmatter SM. Mol Cell Neurosci. 2014 Jul; 2014 Jul 24. PMID: 25066864.