Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells
Datta KK, Patil S, Patel K, Babu N, Raja R, Nanjappa V, Mangalaparthi KK, Dhaka B, Rajagopalan P, Deolankar SC, Kannan R, Kumar P, Prasad TSK, Mathur PP, Kumari A, Manoharan M, Coral K, Murugan S, Sidransky D, Gupta R, Gupta R, Khanna-Gupta A, Chatterjee A, Gowda H. Chronic Exposure to Chewing Tobacco Induces Metabolic Reprogramming and Cancer Stem Cell-Like Properties in Esophageal Epithelial Cells. Cells 2019, 8: 949. PMID: 31438645, PMCID: PMC6770059, DOI: 10.3390/cells8090949.Peer-Reviewed Original ResearchConceptsEsophageal epithelial cellsQuantitative proteomic analysisQuantitative proteomic profilingEpithelial cellsCancer stem cell-like phenotypeElectron transport chainEsophageal squamous cell carcinomaStem cell-like phenotypeTricarboxylic acid cycleMolecular alterationsMitochondrial proteinsTobacco exposurePhosphorylation phenotypeProteomic analysisCell-like phenotypeStem cell-like propertiesMetabolic reprogrammingProteomic profilingCancer stem cell-like propertiesOXPHOS phenotypeStem cell markersChronic exposureTransport chainCell-like propertiesMolecular markers