Publications

• mGluR4-NPDC1 complex mediates α-synuclein fibril-induced neurodegeneration.Perez-Canamas A, Chen M, Almandoz-Gil L, Khan N, Tang SJ, Ho A, Gunther EC, Strittmatter SM. Nat Commun. 2025 Dec 25; 2025 Dec 25. PMID: 41444258.
• Basic Science and Pathogenesis.Salardini A, Hashemi-Aghdam A, O'Dell RS, Hillmer AT, Camacho DF, Dyck KMV, Nelsen K, Ruan A, Lam J, Strittmatter SM, Cosgrove K, van Dyck CH, Mecca AP. Alzheimers Dement. 2025 Dec. PMID: 41445300.
• Preclinical Evidence of Nogo-A Inhibition in Stroke Recovery: A Scoping Review.Lima JEE, Rengarajan S, Wahl AS, Srivatsan A, Strittmatter SM, Carmichael ST, George PM, Sheth KN, Schwab ME, Lansberg MG. Stroke. 2025 Nov; 2025 Aug 27. PMID: 40859844.
• Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice.Mandino F, Kang T, Shen X, Horien C, Papademetris X, Strittmatter SM, Lake EM. bioRxiv. 2025 Oct 28; 2025 Oct 28. PMID: 41278755.
• Distinct Filament Conformation for Receptor-Bound Amyloid-ß from Alzheimer's Disease Brain.Kostylev MA, Butan C, Roseman GP, Liu Y, Gopal P, Strittmatter SM. bioRxiv. 2025 Oct 13; 2025 Oct 13. PMID: 41279998.
• Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8.Kannan R, Wang X, Nicholson L, Lin NZ, Howard EM, Basu A, Ingabire I, Sekine Y, Strittmatter SM. bioRxiv. 2025 Oct 13; 2025 Oct 13. PMID: 41278832.
• Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer's knock-in mouse phenotypes.Nicholson L, Tang SJ, Karra T, Abouelatta H, Strittmatter SM. bioRxiv. 2025 Sep 10; 2025 Sep 10. PMID: 40964391.
• [(18)F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury.Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter SM, Carson RE, Huang Y, Cai Z. J Nucl Med. 2025 Sep 2; 2025 Sep 2. PMID: 40675757.
• The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases.Takahashi H, Strittmatter SM. Mol Neurodegener. 2025 Jul 26; 2025 Jul 26. PMID: 40713630.
• mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration.Perez-Canamas A, Chen M, Almandoz-Gil L, Khan N, Tang SJ, Ho A, Gunther EC, Strittmatter SM. bioRxiv. 2025 Jul 21; 2025 Jul 21. PMID: 40777374.
• Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, da Fonseca EL, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Ikeuchi T, Iqbal T, Pathak O, Valladares O, Reyes-Dumeyer D, Kuzma AB, Abner E, Adams LD, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Auerbach S, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Friedland RP, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Go RCP, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kikuchi M, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, Obisesan T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Petrovitch H, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sabbagh M, Sadovnick AD, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, George-Hyslop PS, Starks TD, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsolaki M, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Miyashita A, Byrd GS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. Genome Biol. 2025 Jul 17; 2025 Jul 17. PMID: 40676597.
• Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator.Mandino F, Shen X, Desrosiers-Grégoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EMR. Mol Psychiatry. 2025 May; 2024 Oct 18. PMID: 39424929.
• Crossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators.Failli V, Strittmatter SM, Schwab ME, Anderson AJ, Ruban A, Al-Ali H, Curt A, Cohen A, Hsieh JTC. Neurotrauma Rep. 2025; 2025 Apr 14. PMID: 40309162.
• The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease.Zeiss CJ, Huttner A, Nairn AC, Arnsten A, Datta D, Strittmatter SM, Wyk BV, Duque A. J Alzheimers Dis. 2025 Apr; 2025 Mar 17. PMID: 40095666.
• Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter SM, Lake EMR. J Neurotrauma. 2024 Dec; 2024 Sep 20. PMID: 39096127.
• CosGeneGate selects multi-functional and credible biomarkers for single-cell analysis.Liu T, Long W, Cao Z, Wang Y, He CH, Zhang L, Strittmatter SM, Zhao H. Brief Bioinform. 2024 Nov 22. PMID: 39592241.
• Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.Liu Y, Tuttle MD, Kostylev MA, Roseman GP, Zilm KW, Strittmatter SM. J Am Chem Soc. 2024 Oct 9; 2024 Sep 26. PMID: 39326869.
• Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.Takahashi H, Perez-Canamas A, Lee CW, Ye H, Han X, Strittmatter SM. Commun Biol. 2024 Sep 5; 2024 Sep 5. PMID: 39237682.
• Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity.Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter SM, Lake E. bioRxiv. 2024 May 26; 2024 May 26. PMID: 38826468.
• Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.Takahashi H, Bhagwagar S, Nies SH, Ye H, Han X, Chiasseu MT, Wang G, Mackenzie IR, Strittmatter SM. Nat Commun. 2024 Feb 16; 2024 Feb 16. PMID: 38365772.
• Aging-Dependent Loss of Connectivity in Alzheimer's Model Mice with Rescue by mGluR5 Modulator.Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, Owens A, Qu A, Onofrey J, Papademetris X, Chakravarty MM, Strittmatter SM, Lake EM. bioRxiv. 2024 Jan 8; 2024 Jan 8. PMID: 38260465.
• Development of neural repair therapy for chronic spinal cord trauma: soluble Nogo receptor decoy from discovery to clinical trial.Howard EM, Strittmatter SM. Curr Opin Neurol. 2023 Dec 1; 2023 Sep 19. PMID: 37865850.
• Neuronal transcriptome, tau and synapse loss in Alzheimer's knock-in mice require prion protein.Stoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter SM. Alzheimers Res Ther. 2023 Nov 15; 2023 Nov 15. PMID: 37968719.
• Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration.Sekine Y, Wang X, Kikkawa K, Honda S, Strittmatter SM. J Biol Chem. 2023 Oct; 2023 Sep 9. PMID: 37690690.
• Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism.Takahashi H, Perez-Canamas A, Ye H, Han X, Strittmatter SM. bioRxiv. 2023 Sep 14; 2023 Sep 14. PMID: 37745346.
• Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial.Maynard G, Kannan R, Liu J, Wang W, Lam TKT, Wang X, Adamson C, Hackett C, Schwab JM, Liu C, Leslie DP, Chen D, Marino R, Zafonte R, Flanders A, Block G, Smith E, Strittmatter SM. Lancet Neurol. 2023 Aug. PMID: 37479373.
• Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium.Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, Woltjer RL, Woon M, Wright CB, Wu CK, Younkin SG, Yu CE, Yu L, Zhu X, Kunkle BW, Bush WS, Wang LS, Farrer LA, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Jun GR, Reitz C, Naj AC. medRxiv. 2023 Jul 8; 2023 Jul 8. PMID: 37461624.
• TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury.Shafit-Zagardo B, Sidoli S, Goldman JE, DuBois JC, Corboy JR, Strittmatter SM, Guzik H, Edema U, Arackal AG, Botbol YM, Merheb E, Nagra RM, Graff S. Cells. 2023 Jun 27; 2023 Jun 27. PMID: 37443768.
• Nogo receptor-Fc delivered by haematopoietic cells enhances neurorepair in a multiple sclerosis model.Ye S, Theotokis P, Lee JY, Kim MJ, Nheu D, Ellen O, Bedford T, Ramanujam P, Wright DK, McDonald SJ, Alrehaili A, Bakhuraysah M, Kang JH, Siatskas C, Tremblay CS, Curtis DJ, Grigoriadis N, Monif M, Strittmatter SM, Petratos S. Brain Commun. 2023; 2023 Apr 4. PMID: 37091588.
• Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
• Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [(18)F]SDM-16.Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter SM, Carson RE, Huang Y, Cai Z. Front Neurol. 2023; 2023 Feb 8. PMID: 36846134.
• Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.de Arce KP, Ribic A, Chowdhury D, Watters K, Thompson GJ, Sanganahalli BG, Lippard ETC, Rohlmann A, Strittmatter SM, Missler M, Hyder F, Biederer T. Nat Commun. 2023 Jan 28; 2023 Jan 28. PMID: 36709330.
• Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2.Rodriguez CM, Bechek SC, Jones GL, Nakayama L, Akiyama T, Kim G, Solow-Cordero DE, Strittmatter SM, Gitler AD. Cell Rep. 2022 Oct 25. PMID: 36288715.
• Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Science. 2022 Sep 30; 2022 Sep 30. PMID: 36007006.
• IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.Clement M, Forbester JL, Marsden M, Sabberwal P, Sommerville MS, Wellington D, Dimonte S, Clare S, Harcourt K, Yin Z, Nobre L, Antrobus R, Jin B, Chen M, Makvandi-Nejad S, Lindborg JA, Strittmatter SM, Weekes MP, Stanton RJ, Dong T, Humphreys IR. Nat Commun. 2022 Sep 8; 2022 Sep 8. PMID: 36075894.
• Correction: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM. Mol Neurodegener. 2022 Aug 30; 2022 Aug 30. PMID: 36038879.
• Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [(11)C]AFM.Fang H, Rossano S, Wang X, Nabulsi N, Kelley B, Fowles K, Ropchan J, Strittmatter SM, Carson RE, Huang Y. Mol Imaging Biol. 2022 Aug; 2022 Jan 12. PMID: 35020138.
• Rabphilin3A reduces integrin-dependent growth cone signaling to restrict axon regeneration after trauma.Sekine Y, Kannan R, Wang X, Strittmatter SM. Exp Neurol. 2022 Jul; 2022 Apr 7. PMID: 35398339.
• Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Sci Transl Med. 2022 Jun; 2022 Jun 1. PMID: 35648810.
• Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Brody AH, Nies SH, Guan F, Smith LM, Mukherjee B, Salazar SA, Lee S, Lam TKT, Strittmatter SM. Mol Neurodegener. 2022 May 3; 2022 May 3. PMID: 35501917.
• An unexpected protein aggregate in diseased and ageing brains.Takahashi H, Strittmatter SM. Nature. 2022 May. PMID: 35379977.
• Multimodal imaging of synaptic vesicles with a single probe.An SJ, Stagi M, Gould TJ, Wu Y, Mlodzianoski M, Rivera-Molina F, Toomre D, Strittmatter SM, De Camilli P, Bewersdorf J, Zenisek D. Cell Rep Methods. 2022 Apr 25; 2022 Apr 25. PMID: 35497490.
• PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging.Toyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. Front Neurosci. 2022; 2022 Mar 8. PMID: 35345546.
• Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells.Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Neuron. 2022 Feb 2; 2021 Nov 18. PMID: 34798047.
• NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates.Boghdadi AG, Spurrier J, Teo L, Li M, Skarica M, Cao B, Kwan WC, Merson TD, Nilsson SK, Sestan N, Strittmatter SM, Bourne JA. Nat Commun. 2021 Nov 25; 2021 Nov 25. PMID: 34824275.
• Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM. J Biol Chem. 2021 Oct; 2021 Sep 2. PMID: 34480901.
• Quantification of SV2A Binding in Rodent Brain Using [(18)F]SynVesT-1 and PET Imaging.Sadasivam P, Fang XT, Toyonaga T, Lee S, Xu Y, Zheng MQ, Spurrier J, Huang Y, Strittmatter SM, Carson RE, Cai Z. Mol Imaging Biol. 2021 Jun; 2020 Nov 30. PMID: 33258040.
• Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.Lindborg JA, Tran NM, Chenette DM, DeLuca K, Foli Y, Kannan R, Sekine Y, Wang X, Wollan M, Kim IJ, Sanes JR, Strittmatter SM. Cell Rep. 2021 Mar 2. PMID: 33657370.
• B-cells expressing NgR1 and NgR3 are localized to EAE-induced inflammatory infiltrates and are stimulated by BAFF.Bakhuraysah MM, Theotokis P, Lee JY, Alrehaili AA, Aui PM, Figgett WA, Azari MF, Abou-Afech JP, Mackay F, Siatskas C, Alderuccio F, Strittmatter SM, Grigoriadis N, Petratos S. Sci Rep. 2021 Feb 3; 2021 Feb 3. PMID: 33536561.
• Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders.Perez-Canamas A, Takahashi H, Lindborg JA, Strittmatter SM. Brain Commun. 2021; 2020 Nov 16. PMID: 33796852.
• Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C, Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. JAMA Neurol. 2021 Jan 1. PMID: 33074286.
• Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Neurobiol Dis. 2020 Nov; 2020 Aug 25. PMID: 32858147.
• Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM. Acta Neuropathol Commun. 2020 Jul 1; 2020 Jul 1. PMID: 32611392.
• Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury.Wang X, Zhou T, Maynard GD, Terse PS, Cafferty WB, Kocsis JD, Strittmatter SM. Brain. 2020 Jun 1. PMID: 32375169.
• A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration.Sekine Y, Lindborg JA, Strittmatter SM. J Biol Chem. 2020 Feb 21; 2019 Nov 20. PMID: 31748413.
• The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival.Schulz A, Sekine Y, Oyeyemi MJ, Abrams AJ, Basavaraju M, Han SM, Groth M, Morrison H, Strittmatter SM, Hammarlund M. J Cell Biol. 2020 Feb 3. PMID: 31968056.
• PET imaging of mGluR5 in Alzheimer's disease.Mecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. Alzheimers Res Ther. 2020 Jan 18; 2020 Jan 18. PMID: 31954399.
• In Vivo Synaptic Density Imaging with (11)C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease.Toyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. J Nucl Med. 2019 Dec; 2019 May 17. PMID: 31101744.
• Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. JAMA Neurol. 2019 Oct 1. PMID: 31329216.
• Whole-Exome Sequencing of an Exceptional Longevity Cohort.Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer MJ, Vilariño-Güell C, Strittmatter SM. J Gerontol A Biol Sci Med Sci. 2019 Aug 16. PMID: 29750252.
• Limiting Neuronal Nogo Receptor 1 Signaling during Experimental Autoimmune Encephalomyelitis Preserves Axonal Transport and Abrogates Inflammatory Demyelination.Lee JY, Kim MJ, Thomas S, Oorschot V, Ramm G, Aui PM, Sekine Y, Deliyanti D, Wilkinson-Berka J, Niego B, Harvey AR, Theotokis P, McLean C, Strittmatter SM, Petratos S. J Neurosci. 2019 Jul 10; 2019 May 6. PMID: 31061088.
• Diltiazem Promotes Regenerative Axon Growth.Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Mol Neurobiol. 2019 Jun; 2018 Sep 19. PMID: 30232777.
• Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.Sekine Y, Algarate PT, Cafferty WBJ, Strittmatter SM. J Neurosci. 2019 Apr 24; 2019 Feb 25. PMID: 30804090.
• Systematic and standardized comparison of reported amyloid-β receptors for sufficiency, affinity, and Alzheimer's disease relevance.Smith LM, Kostylev MA, Lee S, Strittmatter SM. J Biol Chem. 2019 Apr 12; 2019 Feb 20. PMID: 30787106.
• Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.Lee S, Salazar SV, Cox TO, Strittmatter SM. J Neurosci. 2019 Mar 6; 2019 Jan 9. PMID: 30626696.
• Anti-PrP(C) antibody rescues cognition and synapses in transgenic alzheimer mice.Cox TO, Gunther EC, Brody AH, Chiasseu MT, Stoner A, Smith LM, Haas LT, Hammersley J, Rees G, Dosanjh B, Groves M, Gardener M, Dobson C, Vaughan T, Chessell I, Billinton A, Strittmatter SM. Ann Clin Transl Neurol. 2019 Mar; 2019 Feb 27. PMID: 30911579.
• Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM. Cell Rep. 2019 Jan 29. PMID: 30699361.
• Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM. J Neurosci. 2019 Jan 23; 2018 Dec 5. PMID: 30518596.
• Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM. Cell Rep. 2019 Jan 2. PMID: 30605671.
• Liquid and Hydrogel Phases of PrP(C) Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM. Mol Cell. 2018 Nov 1; 2018 Oct 25. PMID: 30401430.
• Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.Dell'Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM. Nat Commun. 2018 Aug 24; 2018 Aug 24. PMID: 30143638.
• Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Cell Rep. 2018 Jul 3. PMID: 29972787.
• Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM. Cell Rep. 2018 Apr 10. PMID: 29642001.
• The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM. Sci Signal. 2018 Apr 3; 2018 Apr 3. PMID: 29615517.
• Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.Smith LM, Zhu R, Strittmatter SM. Neuropharmacology. 2018 Mar 1; 2017 Nov 27. PMID: 29191754.
• Emerging Mechanisms in Alzheimer's Disease and Their Therapeutic Implications.Strittmatter SM. Biol Psychiatry. 2018 Feb 15. PMID: 29331211.
• Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.Kent BA, Strittmatter SM, Nygaard HB. J Alzheimers Dis. 2018. PMID: 29991134.
• Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.Brody AH, Strittmatter SM. Adv Pharmacol. 2018; 2017 Oct 25. PMID: 29413525.
• Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K. Sci Rep. 2017 Sep 21; 2017 Sep 21. PMID: 28935984.
• Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.Salazar SV, Gallardo C, Kaufman AC, Herber CS, Haas LT, Robinson S, Manson JC, Lee MK, Strittmatter SM. J Neurosci. 2017 Sep 20; 2017 Aug 21. PMID: 28842420.
• Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM. J Neurosci. 2017 Jul 26; 2017 Jun 21. PMID: 28637841.
• Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM. Neuron. 2017 Jul 19. PMID: 28728022.
• Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM. Cell Rep. 2017 Jul 5. PMID: 28683325.
• Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease.Heiss JK, Barrett J, Yu Z, Haas LT, Kostylev MA, Strittmatter SM. Cereb Cortex. 2017 Jul 1. PMID: 27365298.
• Rewiring the spinal cord: Direct and indirect strategies.Dell'Anno MT, Strittmatter SM. Neurosci Lett. 2017 Jun 23; 2016 Dec 19. PMID: 28007647.
• Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Acta Neuropathol. 2017 May; 2017 Jan 9. PMID: 28070672.
• Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity.Smith LM, Strittmatter SM. Cold Spring Harb Perspect Med. 2017 May 1; 2017 May 1. PMID: 27940601.
• Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ. Cell Rep. 2017 Mar 14. PMID: 28297672.
• Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease.Salazar SV, Strittmatter SM. Biochem Biophys Res Commun. 2017 Feb 19; 2016 Sep 14. PMID: 27639648.
• Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.Wang X, Sekine Y, Byrne AB, Cafferty WB, Hammarlund M, Strittmatter SM. eNeuro. 2016 Nov-Dec; 2016 Dec 26. PMID: 28032120.
• Axonal branching in lateral olfactory tract is promoted by Nogo signaling.Iketani M, Yokoyama T, Kurihara Y, Strittmatter SM, Goshima Y, Kawahara N, Takei K. Sci Rep. 2016 Dec 21; 2016 Dec 21. PMID: 28000762.
• Inhibiting poly(ADP-ribosylation) improves axon regeneration.Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Elife. 2016 Oct 4; 2016 Oct 4. PMID: 27697151.
• Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles.Han L, Cai Q, Tian D, Kong DK, Gou X, Chen Z, Strittmatter SM, Wang Z, Sheth KN, Zhou J. Nanomedicine. 2016 Oct; 2016 Mar 30. PMID: 27039220.
• Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell'Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N. Cell Rep. 2016 Sep 6; 2016 Aug 24. PMID: 27568284.
• Erasure of fear memories is prevented by Nogo Receptor 1 in adulthood.Bhagat SM, Butler SS, Taylor JR, McEwen BS, Strittmatter SM. Mol Psychiatry. 2016 Sep; 2015 Dec 1. PMID: 26619810.
• Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.Haas LT, Strittmatter SM. J Biol Chem. 2016 Aug 12; 2016 Jun 20. PMID: 27325698.
• SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM. BMJ Open. 2016 Jul 26; 2016 Jul 26. PMID: 27466236.
• Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM. Brain. 2016 Feb; 2015 Dec 14. PMID: 26667279.
• Comprehensive Corticospinal Labeling with mu-crystallin Transgene Reveals Axon Regeneration after Spinal Cord Trauma in ngr1-/- Mice.Fink KL, Strittmatter SM, Cafferty WB. J Neurosci. 2015 Nov 18. PMID: 26586827.
• Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury.Zou Y, Stagi M, Wang X, Yigitkanli K, Siegel CS, Nakatsu F, Cafferty WB, Strittmatter SM. J Neurosci. 2015 Jul 22. PMID: 26203138.