Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice
Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, Xu G. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. The FASEB Journal 2019, 33: 10425-10442. PMID: 31219699, DOI: 10.1096/fj.201900527r.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceKnockdown of TREM2Microglial phagocytosisSynaptic lossSynaptic impairmentPathologic stageAlzheimer's diseasePrevents amyloidosisPS1 miceAmyloid depositionAD pathology developmentSevere amyloid depositionGreen fluorescent protein miceHigh-risk factorsSporadic Alzheimer's diseaseCell antigen-1Thymus cell antigen 1Microglial TREM2TREM2 overexpressionElectrophysiological outcomesSynaptic dysfunctionVirus infectionHippocampal overexpressionPathologic testsMyeloid cells