2022
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesDepressionMiceMice, Inbred C57BLNeuronsObesityPrefrontal CortexStress, PsychologicalConceptsDepressive-like behaviorMedial prefrontal cortexSpontaneous inhibitory postsynaptic currentsSpontaneous excitatory postsynaptic currentsOb/ob miceEmotion-related brain regionsHigh-fat dietAstrocyte reactivationNormal diet miceNeuronal activityBrain regionsGlial reactivationHFD miceSusceptible micePostsynaptic currentsObesogenic factorsOb miceInhibitory postsynaptic currentsNeuronal electrophysiological propertiesRisk of depressionExcitatory postsynaptic currentsWild-type micePrefrontal cortex contributesGlial responseAstrocyte reactivity
2020
NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease
Li Y, Chen M, Zhou Y, Tang C, Zhang W, Zhong Y, Chen Y, Zhou H, Sheng L. NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease. Theranostics 2020, 10: 3579-3593. PMID: 32206109, PMCID: PMC7069072, DOI: 10.7150/thno.40149.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEthanolFatty AcidsFatty LiverHepatocytesInflammationLiver Diseases, AlcoholicMaleMAP Kinase Kinase 1MAP Kinase Kinase 2MiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Oxidation-ReductionPhosphorylationPPAR alphaProtein Serine-Threonine KinasesSignal TransductionConceptsAlcoholic liver diseaseFatty acid oxidationAlcoholic steatosisHepatic fatty acid oxidationHepatocyte-specific deletionHepatic steatosisLiver diseasePPARα agonistAcid oxidationBinge ethanol feedingMain pathological featuresHepatic lipid accumulationEthanol-fed miceRegulation of PPARαRole of NIKALD therapyInflammatory cytokinesPathological featuresUnderlying pathogenesisPharmacological interventionsSteatosisEthanol feedingInflammationPharmacological inhibitionPPARα
2013
proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus
Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H. proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus. Neurochemical Research 2013, 38: 1695-1703. PMID: 23709363, DOI: 10.1007/s11064-013-1071-7.Peer-Reviewed Original ResearchConceptsHippocampal neurogenesisMouse hippocampusAdult mouse dentate gyrusBrains of patientsMouse dentate gyrusAdult mouse hippocampusDouble-positive cellsBrdU-incorporating cellsNerve growth factorHigh-affinity receptorGlial activationSubgranular zoneNeurotrophic factorInhibits neurogenesisDentate gyrusPositive cellsNeurogenic regionsCognitive impairmentAlzheimer's diseaseHippocampusMemory deficitsProNGFNeurogenesisGrowth factorInhibitory effect