proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus
Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H. proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus. Neurochemical Research 2013, 38: 1695-1703. PMID: 23709363, DOI: 10.1007/s11064-013-1071-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBase SequenceCell ProliferationDentate GyrusDNA PrimersIn Situ Nick-End LabelingMaleMiceMice, Inbred C57BLNerve Growth FactorNeurogenesisNeurogliaProtein PrecursorsReal-Time Polymerase Chain ReactionConceptsHippocampal neurogenesisMouse hippocampusAdult mouse dentate gyrusBrains of patientsMouse dentate gyrusAdult mouse hippocampusDouble-positive cellsBrdU-incorporating cellsNerve growth factorHigh-affinity receptorGlial activationSubgranular zoneNeurotrophic factorInhibits neurogenesisDentate gyrusPositive cellsNeurogenic regionsCognitive impairmentAlzheimer's diseaseHippocampusMemory deficitsProNGFNeurogenesisGrowth factorInhibitory effect