2020
Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicroglia
2019
Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice
Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, Xu G. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. The FASEB Journal 2019, 33: 10425-10442. PMID: 31219699, DOI: 10.1096/fj.201900527r.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceKnockdown of TREM2Microglial phagocytosisSynaptic lossSynaptic impairmentPathologic stageAlzheimer's diseasePrevents amyloidosisPS1 miceAmyloid depositionAD pathology developmentSevere amyloid depositionGreen fluorescent protein miceHigh-risk factorsSporadic Alzheimer's diseaseCell antigen-1Thymus cell antigen 1Microglial TREM2TREM2 overexpressionElectrophysiological outcomesSynaptic dysfunctionVirus infectionHippocampal overexpressionPathologic testsMyeloid cells