2022
Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesDepressionMiceMice, Inbred C57BLNeuronsObesityPrefrontal CortexStress, PsychologicalConceptsDepressive-like behaviorMedial prefrontal cortexSpontaneous inhibitory postsynaptic currentsSpontaneous excitatory postsynaptic currentsOb/ob miceEmotion-related brain regionsHigh-fat dietAstrocyte reactivationNormal diet miceNeuronal activityBrain regionsGlial reactivationHFD miceSusceptible micePostsynaptic currentsObesogenic factorsOb miceInhibitory postsynaptic currentsNeuronal electrophysiological propertiesRisk of depressionExcitatory postsynaptic currentsWild-type micePrefrontal cortex contributesGlial responseAstrocyte reactivity
2021
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
Cao R, Li L, Zhang W, Lu J, Wang Y, Chen Q, Zhang W, Chen M, Sheng L, Cai K, Xu G. Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. Biochemical And Biophysical Research Communications 2021, 580: 20-27. PMID: 34607259, DOI: 10.1016/j.bbrc.2021.09.025.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrain Injuries, TraumaticCognitive DysfunctionMaleMelatoninMiceNeuroprotective AgentsConceptsTraumatic brain injuryBrain regionsCognitive improvementCognitive deficitsCognition-related brain regionsMild TBI modelMedial prefrontal cortexAstrocyte reactivationCognitive enhancementCognitive functionPrefrontal cortexDifferent brain regionsMelatonin administrationNeuronal activityClosed head injuryEarly pathological stageUse of melatoninMelatonin attenuatesBrain injuryGlial responseNeuroprotective roleTBI modelDeficitsPathological stageHead injury
2020
p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
Chen M, Guo L, Hao J, Ni J, Lv Q, Xin X, Liao H. p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular And Molecular Neurobiology 2020, 42: 1153-1166. PMID: 33201418, DOI: 10.1007/s10571-020-01006-x.Peer-Reviewed Original ResearchConceptsCortical stab woundAstrocyte proliferationStab woundsMouse astrocytesCell cycle progressionG2/MInjury mouse modelCycle progressionCortical stabP75NTR overexpressionAstrocyte activationFunctional recoveryAstrocytic responseReceptor upregulationBrain traumaAstrocyte apoptosisBrain injuryCDK2 protein levelsMouse modelCDK2 expressionAstrocytesCell cycle entryS phaseProfound alterationsProtein levelsHippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicroglia