Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H. Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats. Brain Behavior And Immunity 2019, 82: 354-371. PMID: 31513876, DOI: 10.1016/j.bbi.2019.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell DifferentiationCell ProliferationExercise TestHippocampusInfarction, Middle Cerebral ArteryMaleNeural Stem CellsNeurogenesisNeuronsPhysical Conditioning, AnimalPhysical ExertionRatsRats, Sprague-DawleyReceptors, ImmunologicRecovery of FunctionSignal TransductionStrokeStroke RehabilitationConceptsCD200/CD200RCognitive functional recoveryTransient middle cerebral artery occlusionFunctional recoveryTreadmill exercisePost-stroke functional recoveryMiddle cerebral artery occlusionExercise-induced neurogenesisPre-existing neuronsCerebral artery occlusionNeurotrophic factor expressionLong-term disabilityPromotion of neurogenesisNeural stem/progenitor cell proliferationCommon treatment strategyTNF-α expressionPotential therapeutic targetAugmentation of neurogenesisStem/progenitor cell proliferationPotential molecular mechanismsProgenitor cell proliferationArtery occlusionIpsilateral hippocampusCD200R expressionSubgranular zone